Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

peptides

product-1400-1400

Cov khoom lag luam

### cov lus qhia ua haujlwm ntawm De De De De Defodutide Peptide: Kev faib tawm, qhov zoo thiab cov khoom siv dag zog thiab cov khoom siv dag zog

#### ** QHIA **

Selodutide (R & D CODE: BIE 456906) yog hom tshuaj peptide, ua ke los ntawm Boehromer Meptide-1 luas} Kev pham kev rog thiab hom 2 {}} Nws muaj cov tshuaj peptodetide, tshuaj lom neeg, cov khoom siv tshuaj lom neeg thiab cov yam ntxwv ua kom zoo nkauj.

---

### ** {{1. cov qauv kev faib tawm thiab kev siv tshuab ntawm kev txiav txim **

Raws li cov hom phiaj kev xaiv thiab cov qauv siv roj av, peptide cov tshuaj uas cov neeg muaj sia nyob tuaj yeem muab faib ua cov hauv qab no:

#### ** {1. ib-lub hom phiaj agonists **

- ** Tus sawv cev raug ": Tsoos GLP -1 Cov} Cov agonists (xws li liraglutide thiab semagloutide).

- ** Cov qauv nta **: muaj tsuas yog GLP-1} Analog ntu, thiab txhim kho insulin tso zais los ntawm kev sim endogenous GLP -1.

- ** * Qhov zoo **: Ntshiab rau cov txiaj ntsig zoo thiab muaj kev nyab xeeb .

- ** QUB TXHEEJ TXHEEM **: Kev tswj hwm tsawg ntawm lub cev hnyav thiab lipid metabolism .

#### ** {{2. dual-phiaj / multi-hom phiaj agonists **

- ** RESFODEATIONS, TIRERODUTIVE, TIRZEPATIDE (GLP-1 / gip dual agonist).

- ** Cov qauv nta **:

- ** RESERODUTIVIDE **: Los ntawm molecular engineering, lub glec -1 thiab gluce acid sab actions yog qhia tau qhia tau qhia tau qhia tau qhia tau qhia tau qhia tau qhia tau qhia tau qhia tau qhia tau qhia tau qhia tau qhia tau qhia

- ** SCHATCHISMISM kev txiav txim ntawm kev nqis tes **: Kev ua kom zoo nkauj ntawm GLP-1 Cov recetors thiab kev txhawb nqa Insetite (txhim kho cov pa hluav taws xob (txhim kho lipolysis).

- ** ** Zoo **:

- ** Kev Koom Tes Meetabolic Cov Kev Cai **: GLP {1} SUCKSES ME TSEEM CEEB HEEV, thiab cov kev sim ua kom yuag tshaj li 15%).

- ** Kev siv roj ntev ntev **: Fatty acid charmification prolongs lub neej ib nrab-lub neej thiab txhawb nqa ib hlis ib zaug {4 4}}

#### *** {{3. triple-hom phiaj agonist (kev tshawb fawb theem) **

- ** Cov qauv nta **: Sib koom zoo GLP-1, gcg thiab gcg (gcg thiab glucose insulinotropic polypeptic) {}}

- ** Cov txiaj ntsig zoo **: Ntxiv rau qhov sib npaug ntawm cov piam thaj thiab lipid metabolism, tab sis kev pheej hmoo ntawm cov kev mob tshwm sim los ntawm kev xaiv tau los ntawm kev siv cov kev xaiv ua kom muaj kev sib npaug.

---

### ** {{2.} Kev faib tawm thiab txhim kho cov phiaj xwm ntawm kev hloov kho tshuaj lom neeg **

Kev hloov kho tshuaj lom neeg ntawm Surodutide yog qhov tseem ceeb rau nws txoj kev ua tau zoo thiab pharconokinetics, thiab tuaj yeem faib ua cov hauv qab no:

#### *** {{1. fatty acid sab act modification (lipidation) **

- ** Cov txheej txheem teaciple **: Kev sib txuas tau txuas c}} C18 fatty acid chains ntawm cov kab mob peptide) .

** ** COV NEEG SAIB XYUAS TSHUAJ ": RIVOODUTIVIDE, semaglutide .

- ** ** Zoo **:

- ** Txuas ib nrab-lub neej **: txo cov ntsiab lus rov los ntawm kev khi rau cov ntshiab albumin, nrog ib nrab-lub neej txog li 7 hnub.

- ** Kev siv hluav taws xob txhim kho **: Reszymatic hydrolysis thiab txhim kho Bioavailability ntawm subcutaneous txhaj tshuaj .

- ** Lub cev thiab tshuaj lom neeg **:

- ** Solubility **: Lub solubility yog txo tom qab kev hloov kho, thiab cov qauv tsim nyog yuav tsum tau ua kom zoo dua qub (xws li tsis hloov pauv pH hloov kho).

- ** Kev sib sau ua ke no yuav tshwm sim ntawm cov kev muaj zog, thiab surfactants (xws li polysorbate 80) yuav tsum tau ntxiv.

#### *** {2. Pgylation Hloov **

- ** Cov txheej txheem qhia txuj ci **: Txuas polyethylene glycol (peg) polymer rau peptide phaus hnyav.

- ** ** Zoo **:

- ** Txo cov immunogenicity **: Peg shields peptide epitide thiab txo cov tshuaj tiv thaiv antibody ntau {}}

- ** Txhim kho cov chaw ua tshuaj phailacokinininis **: Lub sijhawm ntev ntev, tab sis yuav txo cov affinity affinity.

- ** QUB TSHUAJ XEEM ** MOLT MOLECULES tuaj yeem ua rau mob siab thiab raum ntxiv rau cov tshuaj lom, thiab cov ntawv thov kev kho mob tsuas yog txwv.

#### ** {{3. amino acid hloov chaw thiab Cyclization **

- ** Daim Ntawv Thov Kev **:

- ** Kev qhia txog cov am-amino acids **: Xws li AIB (-Ominoobutyric acid) los txhim kho enzyme tsis kam {}}

- ** COLCOLES QAUV **: Ruaj Khov -Helical conformation los ntawm kev puas tsuaj lossis tshuaj lom neeg hla kev ....

- ** "Zoo dua **: Txhim kho cov kev ruaj khov metabolic thiab tus nqi kho kom muaj tshwj xeeb .

---

### ** {{3.} Ntsuas cov khoom siv lub cev thiab tshuaj lom **

#### *** {{1. hnyav hnyav thiab tus qauv **

- ** RESERDRUTIDES **: Molecular hnyav yog hais txog 4 {{{{}}}}, muaj ntawm 39 amino acids, thiab muaj cov roj fatty acid sab act kev hloov kho.

- ** Kev sib piv **: Qhov hnyav molecular ntawm cov tsoos glp -1 analogs (xws li exenatide (xws li exenatide) yog li 4 ..

#### ** {2. solubility thiab stability **

- ** Solubility **:

- **Unmodified peptide**: Easily soluble in water (>50 mg / ml, pH 7 . 4).

- ** Hloov peptide **: Fatty acid los ua rau txo cov solubility (ph 8 {{{{{} 0 tsis muaj co-} 0 tsis yog-hnyav).

- ** STABLY **:

- ** Kev ntsuas kub thiab kub thiab txias yuav tsum tau 2-8℃ntawm lub teeb, thiab lyophilized hmoov tuaj yeem khaws cia ntawm chav tsev kub {}}

- ** PHOO PHEEJ HMOOV **: DEAMIDITION thiab Hydrolysis yog nquag tshwm sim nyob rau hauv acidic tej yam kev mob {}}

#### ** {3. xim thiab morphology **

- **API morphology**: White to off-white lyophilized powder (purity>99%).

- ** A ** Npaj Xim **:

- ** MODY **: COPYLESS pob tshab ua kua (ruaj khov ntawm ph} {.

- ** Ncua tseg **: Milky Dawb (nrog Lipid Carrier).

---

### ** {4. Tsim Kev Loj Hlob thiab Kev Xa Khoom **

#### *** {1.} sa-} Daim Ntawv Thov Txhaj Nkag **

- ** Zoo dua **: Cov neeg mob ua raws siab, txhawb nqa ib zaug kom txhaj tshuaj .

- ** Kev tsim kev sib tw ": cov tshuaj tiv thaiv (xws li Phenol) thiab stabilizers (xws li mannitol) yuav tsum tau ntxiv.

#### ** {{2. ntev ntev-ua yeeb yam sai sai-tso tawm microspheres **

- ** Technology **: PLGA (polylactic-co-glycolic acid) encapsulates peptide peptide {}}

- ** Qhov zoo dua **: Ncua kev tso tawm mus rau 1 hlis, txo qhov nqus tau zaus.

- ** TOM QAB **: Kev tawg tawg thiab cov txheej txheem nyuaj .

#### ** {{3. Lub ncauj Peptide Wakeations (kev tshawb fawb theem) **

- ** Kev thev naus laus zis **: Interic coating ua ke nrog kev ua kom zoo (xws li SNAC) .

- ** Cov nyom **: Tsawg Bioavailability (<5%), requiring high dose compensation.

---

### ** {{{5. kev saib xyuas zoo thiab muaj peev xwm ua lag luam **

#### ** {{1. ua tau zoo rau kev ua tau zoo **

- ** Kev hnyav hnyav **: The Defrodutide theem kev sib txuas tau ua rau muaj qhov hnyav ntawm 14}} 9% hauv 46 lub lis piam (2.8% nyob rau hauv pab pawg placebo).

- **Metabolic improvement**: Significantly reduced liver fat content (>30%) thiab txhim kho insulin rhiab heev .

#### ** {2. kev nyab xeeb **

- ** Cov kev mob tshwm sim ib txwm **: xeev siab, raws plab (raws plab (qhov xwm txheej<20%, mostly transient).

- ** Kev tswj hwm kev pheej hmoo **: Dual-phiaj nyuaj tsis tau muaj kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov xwm txheej plawv .

#### ** {3. khw kev lag luam **

- ** Tso cov kev sib tw **: Piv txwv Novo Nordaglutide thiab Eli Lilly's Tirzepatide.

- ** Dua cov txiaj ntsig sib txawv **: Ua tiav cov kev ua haujlwm siab dua los ntawm GCG receptor ua kom muaj zog, haum rau cov neeg mob uas muaj kev rog hnyav {}}

---

### ** {6. Kev Kawm Kev Loj Hlob Tom Ntej **

{{01.}} ** Ntau hom phiaj synergistic tsim **: Tsim kev sib tw GLP-1 / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg / gcg

2.}}}}}} ece txhaj tshuaj breakfle **: txhawb kev txhim kho ntawm qhov ncauj thiab inhaled npaj.

3.}}} Tus Kheej Kev Kho **: tshuaj ntsuam cov lus teb zoo tshaj plaws los ntawm Genotyping.

---

### ** Xaus **

Rollodutide sawv cev cov qauv ntawm peptide cov tshuaj los ntawm kev siv tshuaj lom neeg thiab cov khoom siv tshuaj lom neeg thiab muab cov tswv yim tshiab rau kev kho mob ntawm lwm yam mob Cov kab mob .