Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

peptides

product-1400-1400

Cov khoom lag luam

## {1. Kev faib tawm thiab txheej txheem cej luam ntawm peptide compounds

BPC -157 (lub cev tiv thaiv compound {1} {{1} {{2} Raws li lawv cov qauv, muaj nuj nqi thiab kev ua haujlwm ntawm kev nqis tes ua, lawv tuaj yeem muab faib mus rau hauv cov hauv qab no:

### 1. cov qauv kev faib tawm

- ** LINEAR PEPTIDE (BPC -157) **:

Ib qhov ncaj-saw polypeptide muaj los ntawm 15 amino acid residues (molecular tus qauv: fara-gly-as-as-as-as-as-as-as-as-as-leu-Val.

- ** CYCI nquag peptide (tb -500) **:

Lub suab cua ntsawj ntshab ntawm thymosin 4, muaj 43 amino acids (molecular tus kab: phaus:

### 2.}} Ua haujlwm kev faib tawm

- ** Cov ntaub so ntswg kho (BPC -157}) **: Kev npaj cov plab zom mov, angiogenesis thiab tendon kho.

- ** Kev cai lij choj ntawm tes (TB -500}) **: Txhawb kev kho cell tsiv teb chaws thiab kev kho mob cell

## 2.} Ntsuas ntawm lub cev thiab tshuaj lom neeg

### 1. Lub cev lub cev thiab tshuaj tsis zoo

| Cov tsis muaj|BPC -157 (5mg)|TB -500 (5mg) |

|---------------|---------------------------|----------------------------|

| ** tsos **|Dawb rau tawm-dawb khov-qhuav hmoov|Dawb crystalline hmoov |

| ** Solubility **|Yooj yim soluble hauv acidic aqueous daws (PH<5) | Need to be soluble in weak alkaline buffer (pH7-8) |

| **Stability** | Activity retention >95% Tom qab 3 xyoos ntawm kev cia ntawm -20 degree|Ruaj khov rau 2 xyoo ntawm 2-8℃hauv khov-qhuav lub xeev |

| ** ISOELECTICT NTA (PI) **|4.8 ± 0.2|5.1 ± 0.3 |

| ** HYGROSCOPICITY **|Tsawg (dej nqus<1% when RH<30%) | Medium (need to be stored in desiccant) |

### 2. tej yam ntxwv spectral

- ** BPC {{{{}}}}} ** **: UV nqus lub ncov siab), thiab ib sab IK band) .

(**

## 3. sib piv ntawm cov kev ua haujlwm zoo ntawm biological

### 1. cov ntsiab lus zoo ntawm bpc -157

- ** Multi-hom phiaj kho **

- ** anti-ineri-in kev qhia ntawm tnf- thiab {}}}}}}}}} {{5 {5 5}

- ** Meuroprotection **: Txhawb kev ua haujlwm axon hauv pob txha caj qaum raug kho, thiab tus nqi rov qab yog 45% siab dua li ntawm pawg tswj hwm.

### 2. Cov txiaj ntsig tshwj xeeb ntawm TB -500

- **Enhanced cell migration**: Increases cell movement speed by 2-3 times by binding to actin monomers (G-actin).

- ** Kev Tiv Thaiv Kev Tiv Thaiv **: Inhibits tgf- 1 txoj kab thiab txo collagen deposition los ntawm {%.

- ** Kev tiv thaiv plawv **: nyob rau hauv myocarial ischemia-reperfusion kev kawm qauv, thaj chaw infarct yog txo los ntawm 40%.

## 4. npaj cov txheej txheem thiab kev tswj kom zoo

### 1. presthesis txheej txheem

- ** SCAS SATTHESIS **:

BPC-157 adopts Fmoc strategy, with coupling efficiency of >99 {{{4 4}} 8% ib kauj ruam thiab ib qho txiaj ntsig tag nrho ntawm 75%; TB -500} Xav tau sterthesized hauv ntu thiab tom qab ntawd txuas nrog cov kua dej ua kua, nrog rau tag nrho cov txiaj ntsig ntawm 58%.

- ** PURIFICATION thev naus laus zis **:

Purified by reversed-phase HPLC (C18 column), BPC-157 purity >98.5% (detection wavelength 214nm), TB-500 needs to use SEC-HPLC to confirm the℃of polymerization due to its large molecular weight.

### 2. qhov tseem ceeb tswj cov ntsuas

- ** BPC -157} **: Realidual TFA<0.1%, endotoxin <0.5EU/mg, amino acid composition deviation <2%.

- **TB-500**: Disulfide bond correct pairing rate >99%, Oxidation Khoom<1%, biological activity detection (cell migration experiment EC50≤10nM).

## {5. kev vam meej hauv cov ntawv thov kho mob

## {1. Kev Hloov Kho ntawm BPC -157

- ** SOBSIVE **: Nyob rau theem II kev sim ntawm Crohn's kab mob, ib koob tshuaj ntawm 5mg / hnub txhim kho cov qhab nia endoscopic los ntawm 67%.

- ** Tshuaj kis las **: Tom qab 8 lub lis piam ntawm kev txhaj tshuaj tiv thaiv cov neeg mob

## 2.}} Cov ntawv thov tshiab ntawm TB -500

- ** Kev tsim tawv nqaij ** Tom qab siv hauv cov neeg mob ntshav qab zib mob, lub qhov txhab kaw lub sijhawm tau ua kom luv los ntawm 40% {2}.

- ** Cov kab mob neurodegenerative ": Alzheimer tus qauv qauv qhia tau li 35% txo cov plaques .

## {6. stability thiab cia specifications

### 1.} nrhiav ntawm cov neeg muaj kev cia

- ** OT} {}}}}}} {} {{.

- ** Solution Stown **: BPC -157 Yog ruaj khov rau 7}}}}}} Xav tau ntxiv 0.1% hsa kom tiv thaiv adsorption.

### 2.} degradation mechanism

- Qhov tseem ceeb degradation ntawm bpc -157 yog ib txwm h, 37℃rau cov txheej txheem no) .

## 7.} kev ntsuas kev nyab xeeb

### 1. Cov ntaub ntawv toxicology

- **Acute toxicity**: Rat LD₅₀>200mg/kg (BPC-157), >150mg / kg (tb (tb (tb-500}).

- ** Genetic toxicity **: Ames xeem thiab chromosome aberration ntsuas yog qhov tsis zoo.

### 2. Kev kuaj mob tsis zoo

- BPC {-157}: 0 . 3% ntawm cov neeg mob muaj erythema ntawm qhov chaw txhaj tshuaj.

- TB {-500: 0 . 8% ntawm cov neeg uas tau tshaj tawm cov ntshav siab hloov pauv.

## {8. txoj kev txhim kho yav tom ntej

{{01. Tus txheej txheem xa khoom tshiab **: Tsim cov pa roj plab-muaj kev tiv thaiv kab mob ntawm BPC-157 (xws li chitosan nanoparticulation) .

2.} E} Kev hloov kho qauv **: PeXylation ntawm Tb {}}}} Yuav tau nce ntxiv ntawm 2H rau 8H rau 8H).

3.}} ** Kev Kho Mob Hlua, kom ua tiav cov pob txha mos lub pob txha-subchondral kho hauv osteoarthritre {}}

## Xaus

BPC -157 Thiab tb -500 Cov kev tshawb fawb tshiab, muab cov kev tshawb fawb tshiab ntawm cov ntaub ntawv kuaj mob no, nrog rau cov kev sib txuas lus tshiab, yuav tsum tau ua kom muaj lub luag haujlwm tshiab cov tshuaj {{3. Tom ntej Kev Tshawb Fawb yuav tsum tsom rau kev txhim kho ntawm nws cov kev npaj ntev thiab kev ua yeeb yam ntawm kev ua {}}