Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

peptides

product-1400-1400

Cov khoom lag luam

#### ** 1. Txheej txheem cej luam **

Botox (botulinum toxin) yog neurotoxin zais cia los ntawm kev ua tiav cov leeg nqaij daim tawv *) Among them, "191aa" refers to a polypeptide fragment composed of 191 amino acids, which is usually an engineered modified toxin core functional region (such as the active fragment of the light chain or heavy chain), with high specificity and low immunogenicity. Botox 191AA Polypeptides tau siv dav hauv cov tshuaj, kev zoo nkauj thiab lawv cov yam ntxwv sib txawv, sib txawv raws cov qauv, muaj nuj nqi thiab txheej txheem kev ua haujlwm.

#### ** 2. Lub ntsiab kev faib tawm ntawm Botox 191AA Polypeptides **

Raws li cov qauv molecular, hloov kho qauv thiab siv, botox 191AA Polypeptides tuaj yeem faib ua cov hauv qab no:

##### ** 1. Ntuj Botox 191AA Polypeptides **

- ** QHOV SIV **: UNMOdified Ntuj Botulinum Toxin Hydrolyzed Fragments.

- ** "Qhov txiaj ntsig **: khaws cia cov kev ua ub no qub, kev ua haujlwm sai (nyob rau lub sijhawm hnub ntawd {1}}}} teev), ntshiab kev ua tau zoo.

- ** Lub cev thiab tshuaj lom neeg **:

- ** Molecular hnyav **: Hais txog 19-21 kda (nyob ntawm cov txheej txheem tshwj xeeb).

- **Stability**: sensitive to heat (needs to be stored below -20 degree ), easily degraded by proteases.

- ** Solubility **: soluble hauv nruab nrab tsis (xws li PBS), isoelectric taw (pi) yog li 5. {}. {}.

- ** Xim **: Lyophilized hmoov yog dawb xoob xoob, thiab tsis muaj xim pob tshab kua tom qab rov kho dua.

##### ** 2. Polyethylene Glycol (Peg) Hloov Hom **

- ** ** ** ** ** OBS MOLCULES tau txuas los ntawm kev sib txuas lus sib txuas los ua kom muaj hydrophilicity thiab hnyav.

- ** ** Zoo **:

- ** Ntu txuas ntxiv ib nrab-lub neej **: Pegylation txo cov kev ua kom pom tseeb thiab lub sijhawm ntev ntawm kev nqis tes ua yog txuas ntxiv rau {2}} lub hlis.

- ** Txo kev immunogenicity **: thaiv cov epigen epitopes thiab txo cov tshuaj tiv thaiv antibody.

- ** Lub cev thiab tshuaj lom neeg **:

- ** Molecular hnyav **: {30-50 kda (nyob ntawm qhov ntev ntawm PG saw).

- ** QIB STURITY **: Txhim kho tshav kub tiv thaiv (tuaj yeem khaws cia thaum 4 degree rau lub sijhawm luv luv), ua kom muaj zog rau enzymatic hydrolysis.

- ** Xim **: Lyophilized hmoov yog daj me ntsis (Peg oxidation yuav ua rau cov xim kom tob tob).

##### ** 3. Lyophilized Npaj thiab Prefilled kua npaj **

- ** SATOPHILIES EVISTS **:

- ** "Cov txiaj ntsig zoo **: Lub neej ntev ruaj khov (txee lub neej {2}}} xyoo), yooj yim thauj.

- ** Lub cev nqaij daim tawv thiab tshuaj lom neeg **: Yuav tsum tau rov hais dua rau kev siv, Ph 6. 8-7. 2 Tom qab reconston.

- ** Xim **: hmoov dawb crystalline.

- ** Cov kua dej ua ntej **:

- ** "Zoo **: Npaj siv, zam kev sib raug zoo.

- ** Lub cev nqaij daim tawv thiab tshuaj lom neeg **: muaj cov stabilizers (xws li tib neeg cov chrornide (sodium chloride), pH 7. {{}}. 3.

- ** Xim **: tsis muaj xim lossis xim ntshiab ntshiab kua.

##### ** 4. Composite peptides (hom phiaj hloov hloov) **

- ** QAUV **: Qhia cov hom phiaj peptides los ntawm kev ua lag luam neuron sib txawv).

- ** ** Zoo **:

- ** ** Kev xa khoom zoo **: Txo cov diffexal diffusion thiab txo cov kev mob tshwm sim (xws li ntsej muag txhav).

- ** Txhim kho kev nkag mus rau **: Txhim kho efficiency ntawm cov caj pas lossis cov ntshav-lub hlwb.

- ** Lub cev nqaij daim tawv thiab tshuaj lom neeg **: cov molecular qhov hnyav yuav nce ntxiv rau ntau tshaj 25 KDA, thiab cov kua txiv yog nyob ntawm cov pab pawg hloov kho.

- ** Xim **: Nyob ntawm kev hloov pauv ntawm cov kev hloov pauv, nws yuav tshwm sim raws li kev ncua ntawv dawb dawb.

#### ** 3. Hauv kev tsom xam ntawm lub cev thiab tshuaj lom neeg **

1. ** Thermal Stability **:

- Lub ntuj yam muaj ib nrab-lub neej ntawm tsuas yog ob peb teev ntawm 25 degree, thiab txoj kev hloov pauv ntawm peg-hloov tuaj yeem txuas tau ntau hnub.

- Kev npaj khov-qhuav tuaj yeem khaws cia ntawm -20 degree rau 3 xyoos dhau los ntawm lub tshuab nqus tsev, nrog ib qho kev ua haujlwm poob ntawm<5%.

2. ** PE rhiab heev **:

- Qhov zoo pH yog 6. 5-7. 5. Acidic ib puag ncig (Ph <5) ua rau kev hloov pauv thiab ploj ntawm kev ua ub no.

3. "Solubility thiab excipient **:

- Cov kuab tshuaj uas feem ntau yog dej rau kev txhaj tshuaj muaj 0. 9% nacl. Ntxiv cov gelatin lossis albumin tuaj yeem txo qis kev kawm tiav.

#### ** 4. Kev tshawb fawb ntawm kev hloov xim **

- ** Daj Labophilized hmoov **: Ib qho cim ntawm kev ua siab tawv (protein sib sau ua ke yog amorphous qauv).

- ** DEJ DEJ **: Tej zaum yuav qhia oxidation ntawm cov qhov seem methionine) lossis kev soj ntsuam, thiab tshuaj ntsuam zoo yuav tsum tau lees tias muaj kev ua si.

- ** Kev raug ncua tsawg **: Liposome encapsulation los yog complex absetield muaj, thiab nws yuav tsum tau shaken ua ntej siv.

#### ** 5. Kev sib piv ntawm cov tub ntxhais zoo **

| ** Qeb **|** Cov txiaj ntsig **|** QAIB NTXIV

|----------------|--------------------------|-------------------------|

| Yam Hom|Kev ua haujlwm siab, tus nqi qis|Tsis muaj zog, yuav tsum tau khaws cia ntawm qhov kub tsis kub |

| Peg hloov hom|Ntev ua yeeb yam, qis immunogenicity|Loj molecular hnyav, qeeb diffusion |

| Hom phiaj hloov pauv|Precision kho, ob peb qhov kev mob tshwm sim|Complex cov txheej txheem ntau lawm, tus nqi siab |

#### ** 6. Kev nthuav dav ntawm cov chaw thov cov chaw **

1. ** Teb Kho Mob **:

- Tsov Rog Migraine (FDA Pom Zoo), Spasmodic Torticollis, Hyperhidrosis.

2. ** FIDE KEV ZOO NKIM **:

- Dynamic wrinkles (brow wrinkles, crow ob txhais taw), ntsej muag slimming (masser nqaij txo).

3. "Teb Kev Tshawb Fawb Kev Tshawb Fawb **:

- Kev tshawb fawb ntawm Neurotransmitter tso tawm mechanism, kev txhim kho kev siv tshuaj.

#### ** 7. Kev tswj kom zoo thiab kev nyab xeeb **

- ** "Cov cim tswj kom zoo **: HPLC Purity> 98%, endotoxin <5 eu / mg.

- ** Kev Nyab Xeeb Tawm Tsam: Cov Khoom Siv Sawv Daws (EDER Edema, mob taub hau), kev ua tsis haum xeeb heev), kev tsis haum tshuaj loj heev yog tsawg (<0.1%).

#### ** 8. Kev cob qhia yav tom ntej **

- ** Kev npaj npaj kho qhov ncauj **: Kev nqus plab hnyuv los ntawm nanocarriers.

- ** Kev hloov kho hauv kev txawj ntse **: Lub teeb-tswj lossis kub-tswj kev tso tawm ntawm peptides kom ua tiav qhov pib nres.

#### ** Xaus **

Botox 191Aa Peptide tseem nthuav dav nws cov khoom siv daim ntawv thov los ntawm cov qauv kev ua kom zoo thiab muab daim ntawv ua kom tshiab. Nyob rau hauv lub neej yav tom ntej, nrog kev nce qib ntawm cov gene kho thiab xa khoom siv thev naus laus zis, nws yuav raug tsim qauv ntxiv, ua qauv tsim kho hauv ntau ciam teb.