HEPIUS Arimidex (Anastrozole) 1mg CAS: 120511-73-1

Arimidex (Anastrozole) yog ib qho khoom siv tshuaj tseem ceeb:

1. Cov ntaub ntawv yooj yim

Lub npe tshuaj: Anastrozole, lub npe lag luam Arimidex.

Hom tshuaj: Nws belongs rau tiam thib peb ntawm non-steroidal aromatase inhibitors, uas muaj cov yam ntxwv ntawm kev xaiv siab thiab ob peb yam tsis zoo.

2. Pharmacological kev txiav txim

Lub ntsiab mechanism: Anastrozole ua rau cov kauj ruam kawg ntawm cov tshuaj estrogen synthesis, inhibits cov kev ua ntawm aromatase, thiab yog li txo cov tshuaj estrogen nyob rau hauv lub cev kua.

Indications: Nws yog tsuas yog siv rau kev kho mob cancer ntawm lub mis siab nyob rau hauv cov poj niam postmenopausal, tshwj xeeb tshaj yog rau cov neeg uas tsis zoo los yog resistant rau tamoxifen.

3. Tshuaj metabolism thiab excretion

Kev nqus thiab kev faib tawm: Anastrozole yog nqus tau sai, thiab lub sijhawm kom ncav cuag qhov siab tshaj plaws ntawm cov tshuaj ntshav siab (tmax) yog 2 teev thaum noj ntawm lub plab khoob, thiab cov ntshav cov tshuaj concentration yog proportional rau cov koob tshuaj.

Metabolism thiab excretion: Anastrozole yog dav metabolized hauv lub cev. 24 teev tom qab kev tswj hwm, lub ntsiab lus tseem ceeb ntawm cov khoom siv hluav taws xob hauv plasma tseem yog anastrozole. Tom qab 72 teev, qhov concentration ntawm cov metabolites nce mus rau tib qhov concentration li anastrozole. Tsis pub dhau 72 teev, tsawg dua 10% ntawm cov qauv tshuaj raug tso tawm hauv cov zis, thiab cov metabolite tseem ceeb tsis muaj aromatase inhibitory nyhuv.

4. Kev noj tshuaj thiab kev tswj hwm

Daim foos thiab cov lus qhia tshwj xeeb: Feem ntau cov ntsiav tshuaj, nrog rau qhov tshwj xeeb ntawm 1 mg / ntsiav tshuaj.

Kev Siv: Hais lus ib hnub ib zaug, 1 ntsiav tshuaj (1 mg) txhua zaus, tuaj yeem noj nrog lossis tsis muaj zaub mov.

Cov pej xeem tshwj xeeb: Rau cov neeg mob uas muaj lub siab ua haujlwm me me lossis me me rau lub raum ua haujlwm tsis zoo, feem ntau tsis tas yuav kho cov koob tshuaj. Txawm li cas los xij, rau cov neeg mob uas muaj lub siab ua haujlwm tsis zoo lossis lub raum tsis ua haujlwm hnyav (creatinine tshem tawm<20ml/min), it should be used with caution or avoided.

5. Kev phiv tshuaj thiab contraindications

Cov kev phiv tshwm sim: nrog rau kub flashes, qaug zog, mob caj dab, mob, mob pob qij txha, kub siab, kev nyuaj siab, xeev siab thiab ntuav, ua pob liab vog, thiab lwm yam. Ntawm lawv, kub flashes yog ib qho kev phiv ntau tshaj plaws.

Cov kev phiv loj heev: Nws tuaj yeem ua rau pob txha thiab pob txha, yog li tus neeg mob cov pob txha yuav tsum tau saib xyuas zoo thaum kho. Tsis tas li ntawd, nws tseem tuaj yeem ua rau muaj cov roj cholesterol ntau ntxiv, thiab yuav tsum tau them nyiaj rau tus neeg mob cov ntshav lipid profile.

Contraindications: nrog rau cov poj niam cev xeeb tub thiab premenopausal, cov neeg mob uas muaj siab rhiab heev rau anastrozole thiab nws formulation excipients, thiab lwm yam. Arimidex yuav ua rau muaj kev phom sij rau tus me nyuam hauv plab thaum noj los ntawm cov poj niam cev xeeb tub, thiab tsis muaj txiaj ntsig kho mob rau cov poj niam premenopausal nrog mob qog noj ntshav.

6. Ceev faj

Kev sib cuam tshuam tshuaj: Txog niaj hnub no, tsis muaj kev cuam tshuam tseem ceeb ntawm anastrozole thiab lwm yam tshuaj tau pom. Txawm li cas los xij, tseem yuav tsum tau saib xyuas kom tsis txhob siv tib lub sijhawm nrog cov tshuaj uas tuaj yeem cuam tshuam.

Cia tej yam kev mob: Arimidex ntsiav tshuaj yuav tsum muab cia rau hauv chav tsev kub ntawm 20 degree thiab 25 degree thiab cia qhuav.

Arimidex (Anastrozole), tseem hu ua anastrozole, yog ib qho kev xaiv uas tsis yog-steroidal aromatase inhibitor. Nws cov ncauj lus kom ntxaws txog kev ua haujlwm tuaj yeem piav qhia los ntawm cov hauv qab no:

1. Inhibition ntawm aromatase

Lub luag haujlwm tseem ceeb ntawm kev ua ntawm anastrozole yog ua haujlwm los ntawm inhibiting aromatase. Aromatase yog ib qho enzyme pom nyob rau hauv tib neeg lub cev uas yog lub luag haujlwm rau hloov qee yam tshuaj steroid rau hauv estrogen. Hauv cov poj niam postmenopausal, aromatase plays lub luag haujlwm tseem ceeb hauv kev hloov pauv ntawm androstenedione uas tsim nyob rau hauv cov qog adrenal rau estrogen. Anastrozole tuaj yeem xaiv inhibit qhov kev ua ntawm aromatase, yog li txo qhov kev hloov pauv no thiab txo qis cov tshuaj estrogen hauv ntshav.

2. Txo cov tshuaj estrogen

Vim nws cov nyhuv inhibitory ntawm aromatase, anastrozole ntse txo cov tshuaj estrogen hauv cov poj niam postmenopausal. Cov nyhuv no ntawm kev txo cov tshuaj estrogen yog qhov tseem ceeb tshwj xeeb rau kev kho mob qog noj ntshav ntawm lub mis, vim tias cov tshuaj estrogen muaj qhov cuam tshuam rau cov qog nqaij hlav cancer mis. Los ntawm kev txo qis cov tshuaj estrogen, anastrozole tuaj yeem cuam tshuam kev loj hlob ntawm cov qog mis, yog li ua lub luag haujlwm hauv kev kho mob qog noj ntshav mis.

3. Txhawb cov tshuaj hormone secretion

Ntxiv nrog rau inhibiting zus tau tej cov tshuaj estrogen, anastrozole kuj tseem tuaj yeem txhawb kev tso tawm ntawm follicle-stimulating hormone (FSH) thiab luteinizing hormone (LH). Ob qho tshuaj hormones no ua lub luag haujlwm tseem ceeb hauv kev tswj cov poj niam cev xeeb tub. Lawv tuaj yeem ua rau lub zes qe menyuam tsim ntau dua testosterone. Txawm hais tias anastrozole feem ntau yog siv rau cov poj niam cov neeg mob, nws tuaj yeem cuam tshuam cov tshuaj hormones ntawm cov txiv neej rau qee yam, xws li kev kho mob ntawm txiv neej hypotesticularism.

4. Daim ntawv thov kev kho mob

Raws li cov txheej txheem saum toj no ntawm kev ua, anastrozole muaj ntau yam kev siv tshuaj kho mob. Nws yog tsuas yog siv los kho mob qog noj ntshav hauv cov poj niam postmenopausal, suav nrog kev kho mob ntawm cov tshuaj hormone receptor-zoo thaum ntxov mob qog noj ntshav, thawj kab kev kho mob ntawm cov tshuaj hormone receptor-zoo lossis tsis paub hauv zos qib siab lossis mob qog noj ntshav metastatic, thiab kev kho mob qog noj ntshav siab nrog cov kab mob. Kev loj hlob tom qab kev kho tamoxifen.

5. Tej yam tshwm sim tshwm sim

Txawm hais tias anastrozole muaj cov txiaj ntsig tseem ceeb hauv kev kho mob qog noj ntshav ntawm lub mis, nws kuj tseem tuaj yeem ua rau muaj qee qhov kev mob tshwm sim. Cov kev mob tshwm sim no suav nrog kev qaug zog, pob txha pob txha (txawm tias qhov no yuav yog qhov teeb meem tsis tshua muaj rau cov neeg siv steroid), nce qib roj cholesterol tag nrho (tshwj xeeb tshaj yog thaum siv nrog lwm cov tshuaj steroids uas aromatize), flushing, anorexia, xeev siab, ntuav, raws plab, kev nyuaj siab, mob taub hau, lossis ua pob liab liab. Yog li ntawd, thaum siv anastrozole, koj yuav tsum ntsuas nws cov txiaj ntsig tiv thaiv nws cov kev pheej hmoo.

Dosage thiab Administration

Cov koob tshuaj pom zoo: Cov koob tshuaj pom zoo rau cov neeg laus (nrog rau cov neeg laus) yog qhov ncauj, ib hnub ib zaug, 1 ntsiav tshuaj txhua zaus (feem ntau yog 1 mg).

Cov pejxeem tshwj xeeb:

Cov menyuam yaus: Arimidex tsis pom zoo rau cov menyuam yaus.

Lub raum tsis zoo: Tsis tas yuav hloov koob tshuaj rau cov neeg mob uas muaj lub raum tsis zoo rau nruab nrab.

Hepatic impairment: Tsis tas yuav tsum tau hloov koob tshuaj rau cov neeg mob uas muaj lub siab tsis zoo.

Hoob kho mob: Rau kev mob qog noj ntshav thaum ntxov, cov kev kho mob pom zoo yog 5 xyoos, tab sis cov chav kawm tshwj xeeb yuav tsum ua raws li tus kws kho mob cov lus qhia.

Cov ntsiab lus tseem ceeb

Arimidex feem ntau yog siv los kho cov kab mob qog noj ntshav hauv qab no:

Kev mob qog noj ntshav siab siab hauv cov poj niam cev xeeb tub: Txawm hais tias cov tshuaj hormone receptor xwm txheej, yog tias tus neeg mob tsis ua haujlwm lossis muaj cov lus teb zoo rau kev kho tamoxifen, Arimidex tuaj yeem txiav txim siab.

Adjuvant kho mob cancer mis thaum ntxov nyob rau hauv cov poj niam postmenopausal nrog cov tshuaj hormone receptor-zoo mob cancer mis: Arimidex tuaj yeem siv los ua kev kho mob ntxiv rau cov neeg mob no.

Mob qog noj ntshav thaum ntxov hauv cov poj niam tom qab yug me nyuam nrog cov tshuaj hormone receptor-zoo mob cancer mis uas tau txais 2 mus rau 3 xyoos ntawm cov tshuaj tamoxifen: Arimidex tuaj yeem siv los ua kev kho mob ntxiv rau cov neeg mob no.

Cov kev ceev faj

Contraindications: Arimidex yog contraindicated nyob rau hauv premenopausal cov poj niam, cev xeeb tub los yog lactating cov poj niam, thiab cov neeg mob uas mob raum tsis ua hauj lwm (creatinine clearance tsawg tshaj li 20 ml / min) los yog nruab nrab mus rau mob siab kab mob.

Kev sib cuam tshuam tshuaj: Lwm cov kev kho mob uas muaj cov tshuaj estrogen tuaj yeem txo cov tshuaj pharmacological ntawm Arimidex, yog li lawv tau txwv tsis pub siv nrog Arimidex.

Cov tshuaj tiv thaiv tsis zoo: Tom qab noj Arimidex, cov neeg mob yuav muaj kev cuam tshuam hauv plab hnyuv (xws li xeev siab, ntuav, thiab raws plab), tsis muaj zog, mob taub hau, yaug, mob nraub qaum thiab lwm yam kev phiv. Tsis tas li ntawd, cov tsos mob xws li dyspnea, peripheral cov ntaub so ntswg edema, qhov chaw mos los ntshav, tawm hws, kub siab thiab hnyav nce kuj yuav tshwm sim.

Nyob rau hauv luv luv, thaum siv Arimidex, cov neeg mob yuav tsum nruj me ntsis raws li tus kws kho mob cov lus qhia kom muaj kev ruaj ntseg thiab ua tau zoo ntawm cov tshuaj. Yog tias koj muaj kev txhawj xeeb lossis tsis xis nyob, koj yuav tsum sab laj nrog kws kho mob raws sijhawm.

Lub ntsiab tseem ceeb ntawm Arimidex (Anastrozole) hauv kev qoj ib ce, tshwj xeeb tshaj yog rau cov neeg tsim lub cev, yog nws lub peev xwm los txo cov tshuaj estrogen hauv lub cev. Cov cuab yeej no yog qhov txaus nyiam rau cov neeg tsim lub cev uas siv cov tshuaj anabolic steroids kom cov leeg nqaij thiab txhim kho kev ua kis las, vim lawv tuaj yeem ntsib ntau yam kev mob tshwm sim vim kev nce qib tshuaj estrogen, xws li gynecomastia (piv txwv li, kev loj hlob ntawm cov qog mis). Txawm li cas los xij, nws yuav tsum raug sau tseg tias Arimidex (Anastrozole) feem ntau paub thiab siv los kho mob qog noj ntshav thiab nws txoj kev siv hauv kev tawm dag zog tsis raug pom zoo lossis pom zoo.

Cov hauv qab no yog cov txiaj ntsig tau txais txiaj ntsig ntawm Arimidex (Anastrozole) hauv kev tawm dag zog (tab sis cov no tsis yog nws tus qauv tsim los yog kev pom zoo siv):

Txo cov tshuaj estrogen: Arimidex (Anastrozole) tuaj yeem txo cov tshuaj estrogen hauv lub cev los ntawm inhibiting cov haujlwm ntawm aromatase enzyme. Qhov no tuaj yeem pab txo cov kev mob tshwm sim los ntawm kev nce qib estrogen, xws li gynecomastia, hauv bodybuilders.

Txo cov nyhuv estrogenic ntawm steroids: Ntau yam steroids aromatize thiab hloov mus rau estrogen hauv lub cev, ua rau muaj kev phiv xws li dej tuav thiab tsis muaj cov leeg txhais (feem ntau hu ua "bitch mis"). Arimidex (Anastrozole) yog ib qho aromatase inhibitor uas tuaj yeem cuam tshuam qhov kev hloov pauv no, yog li txo cov nyhuv estrogenic thaum siv steroid.

Txawm li cas los xij, tseem muaj qhov pheej hmoo tseem ceeb thiab cov kev mob tshwm sim ntawm kev siv Arimidex (Anastrozole) hauv kev tsim lub cev:

Thinning thiab tsis muaj zog ntawm cov pob txha: Cov tshuaj estrogen qis tuaj yeem ua rau cov pob txha tsis muaj zog, yog li ua rau muaj kev pheej hmoo ntawm pob txha.

Kev cuam tshuam rau lwm cov kab mob hauv lub cev: Tus nqi ntawm cov tshuaj estrogen yog qhov tseem ceeb rau kev tiv thaiv kab mob thiab cov hlab plawv. Kev siv ntev ntev lossis siv ntau dhau ntawm Arimidex (Anastrozole) tuaj yeem muaj kev cuam tshuam tsis zoo rau cov tshuab no.

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