HEPIUS Nolvadex (Tamoxifen) 10mg CAS:10540-29-1

Nolvadex (Tamoxifen) yog ib qho tshuaj uas siv ntau yam kev kho mob:

1. Cov ntaub ntawv yooj yim

Lub npe: Tamoxifen

Cov qauv tshuaj: Nws cov mis molecular feem ntau yog C26H29NO (tej zaum yuav txawv nyob ntawm daim ntawv ntsev los yog kev npaj), thiab qhov hnyav molecular yuav txawv nyob ntawm daim ntawv tshwj xeeb, xws li qhov hnyav molecular ntawm citrate daim ntawv loj dua.

Lub cev daim ntawv: Lub citrate ntawm Nolvadex (Tamoxifen) feem ntau yog xim dawb los yog lub teeb daj crystalline hmoov, tsis muaj ntxhiab, maj mam tig daj thaum raug lub teeb, thiab nws nyuaj rau yaj hauv dej, tab sis soluble hauv ethanol thiab acetone.

2. Pharmacological kev txiav txim

Cov nyhuv Antiestrogen: Nolvadex (Tamoxifen) yog cov tshuaj hluavtaws los tiv thaiv estrogen nrog cov qauv zoo li estrogen, uas tuaj yeem sib tw khi rau cov tshuaj estrogen receptors. Hauv thaj chaw estrogen-rhiab heev xws li cov ntaub so ntswg ntawm lub mis, nws tuaj yeem thaiv kev nce qib ntawm cov tshuaj estrogen, yog li inhibiting kev loj hlob ntawm cov qog nqaij hlav cancer ntawm lub mis.

Estrogen receptor modulation: Raws li SERM (xaiv cov tshuaj estrogen receptor modulator), Nolvadex (Tamoxifen) nthuav tawm cov tshuaj tiv thaiv estrogenic hauv qee cov ntaub so ntswg (xws li lub mis) thiab tuaj yeem pom cov tshuaj estrogen zoo li hauv lwm cov ntaub so ntswg (xws li daim siab). Qhov kev ua haujlwm thib ob no tso cai rau nws los txhim kho cov hlab plawv kev noj qab haus huv (tshwj xeeb tshaj yog cov roj cholesterol) thaum kho mob qog noj ntshav.

Testosterone stimulation: Tsis tas li ntawd, Nolvadex (Tamoxifen) kuj muaj zog testosterone stimulating zog. Nws tuaj yeem txhawb nqa lub caj pas pituitary kom nce kev tsim cov tshuaj luteinizing hormone (LH) thiab follicle stimulating hormone (FSH), uas yog gonadotropins uas qhia cov noob qes los tsim testosterone.

3. Daim ntawv thov kev kho mob

Kev kho mob qog noj ntshav mis: Nolvadex (Tamoxifen) yog ib qho tshuaj tseem ceeb hauv kev kho mob qog noj ntshav mis. Nws yog qhov tsim nyog rau cov neeg mob qog noj ntshav mis (thaum ntxov thiab lig) nrog cov tshuaj estrogen receptor ER tsis zoo lossis zoo, thiab rau cov txiv neej cov neeg mob qog noj ntshav. Nws tuaj yeem siv los ua kev kho mob rau kev mob qog noj ntshav siab tshaj plaws, tshwj xeeb tshaj yog rau mob qog noj ntshav siab tom qab lub cev tsis muaj zog. Tsis tas li ntawd, nws tseem tuaj yeem siv los tiv thaiv mob qog noj ntshav hauv cov neeg uas muaj kev pheej hmoo ntawm mob qog noj ntshav mis (xws li BRCA gene mutation carriers).

Lwm daim ntawv thov: Ntxiv rau kev kho mob qog noj ntshav mis, Nolvadex (Tamoxifen) kuj muaj qee yam cuam tshuam rau kev mob qog noj ntshav ntawm zes qe menyuam. Tsis tas li ntawd, nws kuj yog siv rau hauv kev kho mob ntawm cov neeg siv lub cev tsim cov steroid los txhim kho cov roj cholesterol thiab cov hlab plawv. Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias cov kev siv tshuaj kho mob qog noj ntshav mis no tsis tau lees paub lossis pom zoo hauv txhua lub tebchaws.

4. Kev siv thiab ntau npaum li cas

Qhov ncauj: Nolvadex (Tamoxifen) feem ntau yog siv rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm qhov ncauj. Cov koob tshuaj tshwj xeeb yuav txawv nyob ntawm tus neeg mob tus mob, theem kev kho mob thiab tus kws kho mob cov lus qhia. Feem ntau, txhua koob tshuaj yog 10 ~ 20mg, ob zaug ib hnub, thiab tuaj yeem noj tsis tu ncua.

5. Cov tshuaj tiv thaiv tsis zoo thiab ceev faj

Cov tshuaj tiv thaiv tsis zoo: Nolvadex (Tamoxifen) tuaj yeem ua rau muaj kev cuam tshuam tsis zoo thaum kho, suav nrog xeev siab, ntuav, raws plab, kev coj khaub ncaws tsis zoo, amenorrhea, qhov chaw mos los ntshav, ntsej muag, plaub hau poob, ua pob, mob taub hau, kiv taub hau, hnyav nce, edema, pob txha. mob thiab mob qog. Kev siv ntev thiab loj tuaj yeem ua rau pom kev tsis pom kev thiab leukopenia thiab thrombocytopenia.

Kev ceev faj: Nolvadex (Tamoxifen) yuav tsum tau siv nrog ceev faj los ntawm cov neeg mob uas muaj ntshav tsis zoo thiab lub siab ua haujlwm, thiab yog contraindicated tag nrho rau cov poj niam cev xeeb tub. Thaum siv, cov neeg mob yuav tsum ua tib zoo saib xyuas lawv lub cev cov tshuaj tiv thaiv thiab qhia txog qhov tsis xis nyob rau lawv cov kws kho mob raws sijhawm.

Nolvadex (Tamoxifen) yog cov khoom siv tshuaj tseem ceeb uas ua lub luag haujlwm tseem ceeb hauv ntau yam kev kho mob.

1. Nws ua haujlwm li cas

Nolvadex (Tamoxifen) ua haujlwm feem ntau los ntawm cov txheej txheem hauv qab no:

Kev khi rau cov tshuaj estrogen receptors: Tamoxifen yog ib qho kev sib tw estradiol antagonist uas tuaj yeem khi rau cov tshuaj estrogen receptors hauv lub mis thiab lwm yam ntaub so ntswg. Qhov kev khi no tsis txhawb nqa cov ntawv sau lossis muaj cov nyhuv tsis muaj zog, yog li thaiv kev nce qib ntawm estrogen hauv cov ntaub so ntswg.

Kev tswj cov noob qhia: Tamoxifen tuaj yeem tswj cov kev qhia ntawm cov noob muaj feem cuam tshuam los ntawm kev khi rau cov tshuaj estrogen receptors siab. Cov txheej txheem kev tswj hwm no tso cai rau tamoxifen los tawm tsam cov tshuaj estrogenic hauv qee cov ntaub so ntswg, thaum nws tuaj yeem pom cov tshuaj estrogen zoo li hauv lwm cov ntaub so ntswg.

Upregulating transforming kev loj hlob yam: Tamoxifen tuaj yeem txhim kho kev tsim cov kev loj hlob ntawm kev loj hlob. Qhov txo qis ntawm qhov tshwm sim no cuam tshuam nrog kev loj hlob ntawm cov qog nqaij hlav malignant, yog li inhibiting qog hlwb.

Inhibiting protein kinase C: Tamoxifen muaj ib qho kev cuam tshuam tshwj xeeb ntawm cov protein kinase C, uas kuj yog ib qho ntawm cov txheej txheem tseem ceeb ntawm nws cov nyhuv tiv thaiv qog.

2. Qhov chaw tsim nyog rau daim ntawv thov

Nolvadex (Tamoxifen) yog qhov tsim nyog rau thaj chaw kho mob hauv qab no vim nws cov tshuaj pharmacological tshwj xeeb:

Kev kho mob cancer mis:

Nws yog qhov tsim nyog rau cov neeg mob qog nqaij hlav cancer mis (thaum ntxov thiab lig) nrog cov tshuaj estrogen receptor ER tsis zoo lossis zoo, thiab rau cov txiv neej cov neeg mob qog noj ntshav.

Nws tuaj yeem siv rau kev kho mob ntxiv tom qab kev phais mob qog noj ntshav ntau los tiv thaiv kev rov tshwm sim dua.

Cov nyhuv no feem ntau zoo dua rau cov neeg mob qog noj ntshav tom qab yug menyuam thiab mob qog noj ntshav ntawm lub mis 60 xyoo.

Nws muaj cov txiaj ntsig zoo dua ntawm cov qog nqaij hlav cancer mis rau ntawm daim tawv nqaij, cov qog nqaij hlav thiab cov nqaij mos, thaum cov nyhuv ntawm cov pob txha thiab visceral metastasis tsis zoo.

Kev tiv thaiv mob qog noj ntshav mis:

Nws tuaj yeem siv los tiv thaiv cov neeg muaj kev pheej hmoo mob qog noj ntshav mis (xws li BRCA cov noob hloov pauv).

Nws kuj tseem siv tau los tiv thaiv cov poj niam uas muaj tsev neeg keeb kwm ntawm mob qog noj ntshav mis lossis muaj kev pheej hmoo siab mob qog noj ntshav.

Lwm txoj kev kho mob:

Nws tuaj yeem siv rau cov poj niam premenopausal es tsis txhob tshem tawm ntawm zes qe menyuam lossis hluav taws xob castration.

Lwm yam kev siv:

Hauv kev kho mob ntxiv ntawm cov neeg siv lub cev tsim cov tshuaj steroid, Nolvadex (Tamoxifen) tuaj yeem txhim kho qib roj cholesterol thiab mob plawv.

Nws kuj tseem siv tau los kho cov kab mob xws li premenstrual tension syndrome.

3. Ceev faj

Thaum siv Nolvadex (Tamoxifen), koj yuav tsum tau xyuam xim rau cov ntsiab lus hauv qab no:

Cov tshuaj tiv thaiv tsis zoo: Nws tuaj yeem ua rau xeev siab, ntuav, raws plab, kev ua poj niam cev xeeb tub, amenorrhea, los ntshav ntawm qhov chaw mos, tshem tawm ntawm lub ntsej muag, plaub hau poob, pob khaus, mob taub hau, kiv taub hau thiab lwm yam kev phiv tshwm sim. Kev siv ntev thiab loj tuaj yeem ua rau pom kev tsis pom kev thiab leukopenia thiab thrombocytopenia.

Contraindications: Nws yog txwv tsis pub rau cov poj niam cev xeeb tub, thiab nws yuav tsum tau siv nrog ceev faj nyob rau hauv cov neeg mob uas txawv txav cov ntshav thiab lub siab ua hauj lwm.

Kev saib xyuas thiab kev soj ntsuam: Thaum siv, tus neeg mob lub cev cov tshuaj tiv thaiv thiab kev hloov pauv ntawm tus mob yuav tsum tau saib xyuas kom zoo, thiab cov kev ntsuam xyuas thiab kev soj ntsuam yuav tsum tau ua tsis tu ncua.

Kev sib cuam tshuam ntawm cov tshuaj: Nolvadex (Tamoxifen) yuav tsum tsis txhob siv ib txhij nrog qee yam tshuaj, xws li aromatase inhibitors, thiaj li tsis cuam tshuam rau nws cov txiaj ntsig lossis ua rau muaj kev pheej hmoo ntawm kev phiv tshuaj.

1. Kev noj tshuaj thiab lub voj voog

Qhov ntau npaum thiab lub voj voog ntawm Nolvadex (Tamoxifen) feem ntau yog txiav txim siab raws li tus neeg mob qhov xwm txheej tshwj xeeb thiab tus kws kho mob cov lus qhia.

Noj ntau npaum:

Feem ntau, txhua koob tshuaj yog 10 ~ 20 mg, ob zaug ib hnub.

Rau cov neeg mob qog noj ntshav mis, cov tshuaj pib kho mob feem ntau yog 20 mg, tab sis nws tuaj yeem hloov kho raws li qib ntawm tus kab mob thiab cov neeg mob teb. Txawm li cas los xij, koob tshuaj txhua hnub yuav tsum tsis txhob ntau tshaj 40 mg.

Lub voj voog:

Nolvadex (Tamoxifen) tuaj yeem siv tsis tu ncua, tab sis lub voj voog siv tshwj xeeb nyob ntawm tus neeg mob qhov xwm txheej tshwj xeeb thiab tus kws kho mob cov lus qhia.

Thaum kho mob qog noj ntshav mis, kev siv mus sij hawm ntev feem ntau pom zoo kom txog thaum tus mob stabilizes lossis hloov kho raws li tus kws kho mob cov lus qhia.

2. Ceev faj rau kev siv

Kev tshuaj xyuas tsis zoo:

Thaum siv Nolvadex (Tamoxifen), cov neeg mob yuav tsum tau saib xyuas lawv cov kev xav ntawm lub cev thiab tshaj tawm cov tsos mob tsis xis nyob rau lawv cov kws kho mob raws sijhawm.

Cov kev phiv tshwm sim feem ntau muaj xws li xeev siab, ntuav, raws plab, kev coj khaub ncaws tsis zoo, amenorrhea, los ntshav ntawm qhov chaw mos, tshem tawm ntawm lub ntsej muag, plaub hau poob, pob khaus, mob taub hau, kiv taub hau, thiab lwm yam.

Kev siv ntev thiab loj tuaj yeem ua rau pom kev tsis pom kev thiab leukopenia thiab thrombocytopenia.

Contraindications:

Nolvadex (Tamoxifen) yog contraindicated nyob rau hauv cov poj niam cev xeeb tub, vim hais tias nws yuav muaj kev phiv rau tus me nyuam hauv plab.

Cov neeg uas suav cov ntshav txawv txav thiab lub siab thiab lub raum ua haujlwm yuav tsum tau siv cov tshuaj no nrog ceev faj.

3. Kev sib txuam tshuaj yeeb:

Nolvadex (Tamoxifen) yuav tsum tsis txhob siv ib txhij nrog qee yam tshuaj, xws li tshuaj tiv thaiv kab mob (xws li ranitidine, cimetidine, thiab lwm yam), vim tias lawv tuaj yeem hloov pauv pH tus nqi hauv plab, ua rau cov tshuaj nkag mus rau hauv lub plab zom mov ua ntej thiab ua rau lub plab. .

Thaum siv ua ke nrog warfarin lossis lwm yam coumarin anticoagulant, cov nyhuv anticoagulant tuaj yeem nce ntxiv, yog li cov neeg mob yuav tsum tau saib xyuas zoo thaum siv ua ke.

Thaum siv ua ke nrog cov tshuaj cytotoxic, qhov kev pheej hmoo ntawm thromboembolism nce.

Siv rau hauv cov neeg tshwj xeeb:

Nolvadex (Tamoxifen) yog contraindicated rau cov poj niam cev xeeb tub thiab lactating.

Cov tshuaj no tsis pom zoo rau cov menyuam yaus.

Cov neeg uas muaj lub siab ua haujlwm tsis zoo yuav tsum siv cov tshuaj no nrog ceev faj thiab yuav tsum tau saib xyuas lub siab ua haujlwm tsis tu ncua.

Lwm yam kev ceev faj:

Thaum siv Nolvadex (Tamoxifen), cov neeg mob yuav tsum tau kuaj xyuas tsis tu ncua, xws li cov ntshav niaj hnub, kuaj lub siab thiab lub raum, thiab lwm yam, txhawm rau saib xyuas cov teebmeem ntawm cov tshuaj hauv lub cev.

Yog tias tus neeg mob ntsib qhov tsis xis nyob lossis mob hnyav dua thaum siv, nws yuav tsum mus ntsib kws kho mob tam sim ntawd thiab qhia rau tus kws kho mob tias nws siv cov tshuaj no.

Nolvadex (Tamoxifen) yuav tsum tau muab cia rau hauv qhov chaw qhuav, txias, tsaus kom ntseeg tau tias muaj kev ruaj ntseg thiab ua haujlwm zoo ntawm cov tshuaj.

Nolvadex (Tamoxifen) muaj ntau qhov txiaj ntsig zoo hauv kev tawm dag zog, tshwj xeeb tshaj yog rau cov neeg nyiam noj qab haus huv uas siv cov tshuaj anabolic steroids.

1. Tiv thaiv Gynecomastia

Raws li cov tshuaj tiv thaiv estrogen, Nolvadex muaj peev xwm khi rau cov tshuaj estrogen receptors hauv qee qhov ntawm lub cev, tshwj xeeb tshaj yog nyob rau hauv cov ntaub so ntswg ntawm lub mis, yog li tiv thaiv cov tshuaj estrogen los ntawm kev ua ntawm nws qhov chaw khi qub.

Rau cov neeg nyiam noj qab haus huv uas siv cov tshuaj anabolic steroids, nce qib tshuaj estrogen tuaj yeem khi rau cov ntaub so ntswg ntawm lub mis thiab ua rau txiv neej lub mis loj hlob. Cov cuab yeej no ntawm Nolvadex ua rau nws muaj txiaj ntsig zoo rau kev tiv thaiv gynecomastia.

2. Txhim kho cov roj cholesterol

Nolvadex nthuav tawm cov teebmeem estrogenic hauv daim siab, thiab qhov kev ua haujlwm ntawm lub siab estrogenic tau pom los txhim kho cov hlab plawv kev noj qab haus huv, tshwj xeeb tshaj yog cuam tshuam txog qib roj cholesterol.

Feem ntau cov tshuaj anabolic steroids yuav muaj kev cuam tshuam tsis zoo rau cov roj cholesterol, thaum Nolvadex pab txhim kho tus mob no thiab muaj txiaj ntsig zoo rau cov hlab plawv kev noj qab haus huv ntawm cov neeg nyiam noj qab haus huv.

3. Txhawb nqa testosterone ntau lawm

Nolvadex tuaj yeem thaiv cov lus pom tsis zoo los ntawm cov tshuaj estrogen hauv hypothalamus thiab pituitary caj pas, yog li txhawb kev tso tawm ntawm pituitary luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH).

LH thiab FSH yog gonadotropins uas qhia cov noob qes los tsim cov testosterone thiab yog qhov tseem ceeb rau kev tsim cov tshuaj testosterone. Yog li ntawd, cov cuab yeej no ntawm Nolvadex pab cov neeg tsim lub cev rov zoo li qub testosterone qib tom qab tso tseg kev siv cov tshuaj anabolic steroids.

4. Raws li PCT (Post-Anabolic Steroid Therapy) Tshuaj

Nolvadex feem ntau yog siv los ua cov tshuaj PCT los pab cov neeg tsim lub cev rov qab ua haujlwm ntawm lub cev tom qab tso tseg kev siv cov tshuaj anabolic steroids.

Los ntawm kev txhawb nqa testosterone ntau lawm thiab txhim kho qib roj cholesterol, Nolvadex pab txo qis cov tsos mob ntawm testosterone thiab lwm yam tsis xis nyob uas cov neeg tsim lub cev yuav ntsib thaum PCT.

5. Lwm yam zoo dua

Ntxiv nrog rau cov txiaj ntsig saum toj no, Nolvadex kuj tseem tuaj yeem muaj cov khoom tiv thaiv kab mob qog noj ntshav, uas ua tiav los ntawm kev thaiv cov protein kinase C (PKC) los ntawm oxidative stress mechanism. Txawm li cas los xij, kev siv ncaj qha ntawm qhov txiaj ntsig no hauv kev qoj ib ce yuav tsum tau tshawb fawb ntxiv.

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