Hauj lwm lawm

Kev tsis

Taw qhia

Kisspeptin2

musclepic 4

Khoom Description

1. Cov ntsiab lus tseem ceeb thiab kev faib tawm ntawm Kisspeptin

Kisspeptin yog ib lo lus dav dav rau cov kab peptide molecules encoded los ntawm KISS1 noob. Cov peptides tuaj yeem tsim ntau yam khoom tawg yooj yim los ntawm kev sib txawv cleavage mechanisms. Tam sim no, feem ntau hais hauv kev tshawb fawb thiab kev lag luam suav nrog:

1. Kisspeptin-54

54 amino acids nyob rau hauv ntev, nws yog qhov ntxov tshaj plaws nrhiav tau thiab feem ntau biologically tiav daim ntawv, muaj tsis tshua muaj siab receptor affinity.

2. Kisspeptin-14

Luv luv molecule, refined qauv, tuav tus yuam sij C-terminal sib lawv liag, muaj zog lom lom.

3. Kisspeptin-13 / Kisspeptin-10

Luv luv, me me peptide fragments, nrog rau qhov zoo hauv kev ruaj ntseg zoo dua thiab kev siv nyiaj txiag ntau dua, thaum tseem ua rau GPR54 (KISS1R) receptor.

4. Kev faib tawm ntawm High -Quality Peptide Qib

Raws li kev coj dawb huv thiab kev npaj siv, Kisspeptin tuaj yeem faib ua:

**Research Grade:** Typically >95% purity, used for cell experiments, animal experiments, etc. **Pharmaceutical Grade (GMP Grade):** Purity >98-99%, nrog nruj impurity tswj, ua tau raws li kev tsim kho tshuaj.

** Hloov kho Peptide: ** tuaj yeem ua acetylated, amidated, lipidated, lossis PEGylated los txhim kho kev ruaj ntseg.

Cov khoom sib txawv muaj rau kev xaiv hloov tau raws li daim ntawv thov thiab pob nyiaj siv.

2. Cov txiaj ntsig tseem ceeb ntawm High-Kisspeptin Zoo

Kisspeptin yog ib qho tshiab, cov teeb liab muaj zog peptide, uas nws cov yam ntxwv tau ua rau nws ua kom pom tseeb ntawm kev tshawb fawb thiab kev tsim tshuaj.

1. Siab Bioactivity thiab Targeting

Kisspeptin muaj kev sib raug zoo heev rau KISS1R receptor thiab yog ib qho muaj zog tshaj plaws paub GnRH secretion stimulants, ua lub luag haujlwm tseem ceeb hauv kev tswj cov kev ua me nyuam.

2. Natural Source thiab Well-Defined Structure

Kisspeptin yog muab los ntawm endogenous biomolecules, ua kom yooj yim rau lub cev kom paub txog thiab metabolize, nrog rau lub hauv paus muaj kev ruaj ntseg zoo.

3. Kev koom tes dav thoob plaws ntau lub tshuab

Nws qhov kev tshawb fawb tus nqi nthuav dav ntau thaj chaw:

Tshuaj Kho Mob

Hormonal Regulation nyob rau hauv Puberty thiab Adulthood

Tumor Metastasis Related Research

Zog Metabolism Balance, Obesity Mechanisms

Cov kab mob plawv thiab kev xav cwj pwm

4. Yooj yim rau Peptide Engineering

C-terminal sequence yog ib qho tseem ceeb txuag ntu; Yog li ntawd, Kisspeptin txoj kev ruaj ntseg thiab ib nrab - lub neej tuaj yeem txhim kho tau yooj yim thiab ntev los ntawm kev hloov pauv amino acid, amidation, thiab lipid hloov kho, muab qhov chaw rau kev tsim kho.

3. Kev piav qhia ntxaws txog Physicochemical Properties

Raws li peptide raw khoom, Kisspeptin muaj ib tug series ntawm physicochemical zog:

1. Molecular Structure

Tsim los ntawm ntau cov amino acids txuas los ntawm peptide bonds.

C-terminal sequence yog qhov tseem ceeb hauv cheeb tsam.

Muaj cov isoforms sib txawv (piv txwv li, 10, 13, 14, 54 amino acids).

N-terminal los yog C-terminal modifications tuaj yeem ua raws li qhov xav tau los txhim kho kev ruaj ntseg.

2. Molecular Weight Range

Kisspeptin-10: Kwv yees li 1300–1500 Da

Kisspeptin-14: Kwv yees li 1700–1800 Da

Kisspeptin-54: Kwv yees li 6000–7000 Da

Qhov hnyav molecular sib txawv ua rau muaj qhov sib txawv me ntsis hauv kev ruaj ntseg, metabolic tus nqi, thiab muaj peev xwm ua kom receptor.

3. Solubility

Yooj yim soluble hauv dej thiab dilute acidic buffer daws.

Tseem soluble nyob rau hauv feem ntau siv physiological tsis xws li PBS thiab HEPES.

rhiab heev rau qhov kub thiab txias; qis- qhov kub thiab txias cia yog pom zoo.

4. Kev ruaj ntseg

Lyophilized hmoov muaj kev ruaj ntseg zoo.

Yuav khaws cia ntev -lub sij hawm tiv thaiv los ntawm lub teeb thiab ntawm qhov kub thiab txias (−20℃lossis qis dua).

luv- siv lub sij hawm yog tsim nyog nyob rau hauv cov tshuaj raws li peptide chains yog nquag hydrolysis los yog oxidation.

5. Charge Properties thiab Isoelectric Point

Feem ntau weakly acidic.

Isoelectric point feem ntau yog nruab nrab ntawm pH 5 thiab 7.

Pom zoo receptor khi ua haujlwm ntawm lub cev pH.

4. Cov tsos thiab cov ntaub ntawv raw

Cov yam ntxwv zoo li ntawm siab -Kisspeptin zoo feem ntau suav nrog:

1. Xim

High-cov khoom purity yog dawb los tawm-cov hmoov dawb lyophilized.

Kev tswj tsis zoo yuav ua rau cov xim daj daj, tab sis cov khoom lag luam feem ntau tsis muaj xim.

2. Daim ntawv

Feem ntau muab los ua ** lyophilized hmoov ** .

Zoo, lub teeb yuag hmoov tsis muaj qhov pom tseeb.

3. Cov ntxhiab tsw thiab lwm yam khoom

Tsis hnov tsw tsw

Tsis zoo li -hygroscopic, tab sis ntev - lub sij hawm raug tseem yuav cuam tshuam rau stability

Cov yam ntxwv no pab txhawb kev thauj mus los, khaws cia, thiab kev sim ua haujlwm.

5. Kev ua haujlwm lom neeg thiab cov cuab yeej ua haujlwm

Kisspeptin cov txheej txheem tseem ceeb ntawm kev ua haujlwm yog nyob ib ncig ntawm hypothalamic{0}}pituitary-gonadal axis (HPG axis).

1. Ua kom muaj GnRH Secretion

Kisspeptin activates GnRH neurons los ntawm kev ua ntawm KISS1R, yog li cuam tshuam:

LH secretion

FSH secretion

Kev tswj hwm ntawm gonadal cov tshuaj hormones

Cov txheej txheem no ua rau nws yog lub hom phiaj tseem ceeb rau kev kawm txog kev yug me nyuam.

2. Qhov tseem ceeb hauv kev pib puberty

Qhov pib ntawm kev puberty yog suav tias yog ze ze rau kev txhim kho Kisspeptin signaling, ua rau nws yog ib qho tseem ceeb ntawm kev tshawb fawb hauv kev loj hlob ntawm pubertal.

3. Anti-cov qog ntsig txog kev tshawb fawb

KISS1 noob yog ib qho ntawm "tiv thaiv- cov kab mob metastasis," thiab Kisspeptin tau kawm nyob rau hauv ntau hom qog nqaij hlav rau kev tswj cov qog cell tsiv teb tsaws.

4. Lub zog Metabolism thiab tswj qhov hnyav

Kisspeptin neurons cuam tshuam nrog cov teeb meem metabolic xws li leptin thiab insulin, thiab suav tias yog tus choj ntawm lub cev lub zog lub xeev thiab kev ua me nyuam.

5. Kev Tshawb Fawb Txog Kev Nyuaj Siab thiab Kev Nyuaj Siab

Qee qhov kev tshawb fawb qhia tias Kisspeptin tuaj yeem cuam tshuam rau lub siab lub ntsws, xws li limbic system kev ua haujlwm, thiab yog li ntawd nws tau maj mam nkag mus rau hauv kev tshawb fawb neurobehavioral.

6. Daim ntawv thov kev cia siab thiab kev lag luam tus nqi

Kisspeptin lub peev xwm ua rau nws muaj kev tshawb fawb hotspot nyob rau hauv ntau qhov chaw:

1. Kev Tshawb Fawb Txog Tshuaj Kho Mob

Siv los kawm:

Ncua puberty thiab precocious puberty

Kev ua haujlwm ntawm cov tshuaj hormones

Hypothalamic tswj mechanisms

2. Kev txhim kho ntawm Novel Peptide Tshuaj

Vim nws lub hauv paus ntuj thiab cov teeb liab tshwj xeeb, nws suav hais tias yog tus neeg sib tw peptide rau cov tshuaj tsom, siv rau hauv kev txhim kho cov neeg tswj hwm tshiab yav tom ntej.

3. Oncology Research Model

Siv los kawm cov qog metastasis mechanisms thiab inhibition pathways, muab kev nkag siab txog cov tswv yim kho mob.

4. Neuroscience thiab Metabolic Fields

Tshawb nrhiav nws lub luag haujlwm hauv lub hlwb teeb liab, kev tswj hwm lub zog, thiab tus cwj pwm.

5. Kev Tsim Kho Platform rau Peptide Engineering

Nws cov qauv qauv tsim nyog rau kev hloov kho, xws li:

Structure stabilization

Ib nrab - lub neej txuas ntxiv

Lub hom phiaj xa khoom tsim

Qhov no pab txhawb kev tsim kho tshiab hauv peptide formulations.

7. Cov lus xaus

Kisspeptin, raws li qib siab -cov teeb liab zoo peptide nrog qhov tseem ceeb ntawm cov roj ntsha tseem ceeb, tau tshwm sim sai heev hauv cov kev tshawb fawb tshawb fawb thiab kev tsim tshuaj vim nws cov qauv tshwj xeeb, kev ua haujlwm lom neeg muaj txiaj ntsig zoo, thiab cov khoom muaj txiaj ntsig zoo ntawm lub cev. Nws cov yam ntxwv meej meej, zoo lyophilization stability, tunable active fragments, thiab cov nqi tseem ceeb nyob rau hauv ntau lub cev xws li kev yug me nyuam, metabolism, thiab oncology ua rau nws yog ib tug tseem ceeb kev tshawb fawb khoom nyob rau hauv niaj hnub peptide technology.