99% ntshiab sermorelin hwm zoo peptide 2mg / vial

### cov lus qhuab qhia peptides: kev tshuaj ntsuam xyuas txoj cai

Cov thwj tim tau yog ib qho kev loj hlob ntawm cov khoom siv hluav taws xob (GHRH) Analogue, uas yog cov kev tshawb fawb ua si thiab kev tawm tsam kev tswj hwm kev loj hlob tuaj yeem tswj hwm kev loj hlob. Kab lus no yuav pom cov lus qhuab qhia thiab nws cov derivatives los ntawm cov qauv ntawm cov qauv tshuaj, kev faib tawm, kev siv thiab kev nyab xeeb.

### 1. Cov theem pib Txheej txheem cej luam ntawm Sermorelin

#### 1. Keeb kwm thiab keeb kwm yav dhau los

Sermorelin (tseem hu ua ghrh ({{{{0} ormone (ghrh, muaj 44 amino acids), khaws cia tsuas yog thawj 29 amino acid sequides. Nyob rau xyoo 1980, cov kws tshawb fawb pom tias qhov tseem ceeb ntawm GHRH yog nyob ntawm n-terminal}, thiab yog li tau tsim cov lus qhuab qhia rau lub neej ib nrab thiab txhim kho kev ruaj khov.

### 2. Mechanism ntawm Kev Ua

Cov lus qhia txog cov Adenylate Cyclate-Camp Nws cov nyhuv yog nyob ntawm cov qauv pulsed zais pa, simulating lub cev pob tw, simulating fysiological g tso, thiab txo cov kev mob tshwm sim ntawm exogenous GH.

### 2. Kev faib tawm thiab derivative cov ntaub ntawv ntawm cov lus qhuab qhia

Raws li kev hloov kho tshuaj, kev siv tshuaj thiab cov qauv sib xyaw, cov lus qhuab qhia tuaj yeem faib ua cov hauv qab no:

#### ** 1. Sermorelin acetate **

- **Chemical structure**: It is composed of 29 amino acids (Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂), C-terminal amidation to improve stability, usually exists in the daim ntawv ntawm acetate.

- ** Cov khoom siv lub cev **:

- ** Molecular hnyav **: 3357.9 da.

- **Solubility**: Easily soluble in water (>5 {0 mg / ml), feem ntau ruaj khov ntawm Ph 4. 0-6. 0.

- ** Xim thiab daim foos **: Dawb rau off-dawb khov-qhuav hmoov, tsis muaj xim thiab pob tshab siv tom qab rov kho dua tshiab.

- ** ** Zoo **: Ib nrab-lub neej (txog {10-20 feeb) yog ntev dua li ntuj ghrh, bioavailability yog siab, thiab cov ntshav siab tom qab txhaj tshuaj.

#### ** 2. Kev So kom tso nyiaj tso tawm siv cov nqi (cov lus qhuab qhia Acetate SR) **

- ** Cov yam ntxwv technical **: Txuas lub voj voog tso tawm los ntawm cov micrapsersh lossis liposome encapsulation technology.

- ** Cov khoom siv lub cev **:

- ** Particle loj loj **: microshiares txoj kab uas hla}} μm, liposome particle loj li 100 nm.

- ** Qhab ** (2-8} degree) yuav tsum tau tswj kev ncaj ncees.

- ** "Cov nyhuv **: Cov nyhuv muaj peev xwm kav rau 24-72}} sijhawm tom qab kev txhaj tshuaj ib zaug, txo cov zaus ntawm kev tswj hwm.

#### ** 3. Cov qauv hluav taws xob loj peptide "

- ** Sermorelin + GHRP (Kev Loj Hlob Lawm Tshaj Tawm Tso Peptide) **:

- ** Tus sawv cev sib xyaw ua ke **: Sermorelin + iSamorelin (GHRP -2 analogue).

- ** QIB SYNOGATORCORATIONS **: GHRP Qhib Gh Secition los ntawm Motilin Recayway ntawm cov lus qhia txog cov lus txhawb nqa GLOPS tso tawm los ntawm 3-5 lub sij hawm.

- ** Cov khoom siv lub cev **: Kev daws tom qab sib txuas yog lub teeb daj (vim qhov sib ntxiv ntawm cov tshuaj tiv thaiv kab mob antioxidants), pH}. 0.

- ** "Zoo **: Ntau hom phiaj kev txhawb zog, haum rau qhov kev ua kom tsis taus lossis tiv thaiv kev laus.

#### ** 4. Qhov ncauj / Nasal mucosal xa khoom **

- ** Kev kho kev txhim kho kev txhim kho **: Ntxiv kev txhawb nqa kev ua tiav (xws li Chitosan) lossis enzyme inhibitors (xws li aproteinin).

- ** Cov khoom siv lub cev **:

- ** Daim ntawv Dosage **: Cov ntsiav tshuaj (muaj cov ntaub ntawv (muaj cov ntaub ntawv microshrothules), cov tshuaj maj phaub (qhov loj me<50 μm).

- ** Xim **: Cov ntsiav tshuaj feem ntau yog xim dawb, thiab kev kub siab thiab cov dej hiav txwv tsis muaj kob.

- ** "Qhov txiaj ntsig **: Tsis yog tus tswj hwm tsis zoo, tab sis qis bioavailability (txog {{%).

### 3. Hauv kev tsom xam ntawm lub cev ntawm lub cev muaj zog

#### 1. ** Thermal Stability **

- ** Labophilized hmoov **: Ruaj khov rau 2 xyoo ntawm 25 degree, ntsuas kev nrawm ntawm 40 degree pom kev ua kom tsis pom zoo<5% within 6 months.

- **Solution state**: >90% kev ua haujlwm khaws cia tsis pub dhau 7 hnub thaum khaws cia ntawm 4 degree, kev tsis txaus siab ncav cuag 30% tom qab 48 teev ntawm chav tsev kub (25 degree).

#### 2. ** Yees duab **

- rhiab rau ultraviolet rays, yuav tsum tau muab cia kom deb ntawm lub teeb. Raug rau 300-400 nm teeb, kev ua kom tsawg dua 40% hauv 24 teev.

#### 3. ** PHEM HOM PHIAJ **

- The optimal pH range is 4.0-6.0. Deamidation is prone to occur when pH >7. {0; pH<3.0 leads to peptide chain hydrolysis.

#### 4. ** Kev sib xyaw **

- Tau tshaj nrog kev paub txog xws li sodium chloride thiab mannitol, tab sis nrawm nrawm thaum raug oxidants (xws li hydrogen peroxide).

### 4. Kev nthuav dav ntawm cov chaw thov

### 1. ** Cov tshuaj kho mob **

- ** Kev loj hlob tuaj me nyuam yaus tsis txaus (GHD) **: subcutaneous txhaj tshuaj ntawm {1}}}}}}}}%.

- ** Cov neeg loj hlob muaj peev xwm loj (ughd) **: txhim kho lub cev rog lub cev, cov pob txha ceev thiab zoo ntawm cov qhab nia hauv lub neej.

### 2. ** Kev tiv thaiv kev laus thiab cov tshuaj kho mob "

- ** Xwm Txheej txheem **: Txhawb cov synagen synthesis thiab txo cov oxidative kev puas tsuaj los ntawm -1 Kev kho kom haum xeeb. Cov chaw sim kho mob qhia tias 6 lub hlis ntawm kev kho mob ntxiv daim tawv elasticity los ntawm 20%.

- ** QIB CHAWS REGIMEN **: Txhaj 0. {{}. 3 mg Txhua hmo ua ntej pw rau {4}} lub hlis.

#### 3. ** Kev ua kis las ncaws pob "

- ** Qeeb synthesis **: Ua ke nrog kev cob qhia tawm tsam, cov leeg loj nce yog 15% siab dua li pawg tswj hwm.

- ** Rov ua haujlwm rov qab **: Txo cov tsiaj txhu Kinase (CK) tom qab kev ua haujlwm siab ua haujlwm los ntawm 30%.

### 5. Kev nyab xeeb thiab cov kev mob tshwm sim

#### 1. ** Cov cai uas tsis zoo **

- Kev txhaj tshuaj tiv thaiv cov kev tawm tsam (Erherema, khaus, muaj qhov tsis muaj {1}}%).

- Hloov hyperglycemia (2-5}% ntawm cov neeg mob).

### 2. ** Tej yam me me **

- Cov neeg mob uas muaj cov qog ua haujlwm, cev xeeb tub thiab lub txim tsis muaj qhov tsis raug rau.

#### 3. ** Kev nyab xeeb ntev **

- Tsis muaj kev nce qib hauv plab tau pom hauv kev taug xyuas ntau tshaj 5 xyoos, tab sis Igf {{qib yuav tsum tau saib xyuas tsis tu ncua.

### 6. Yav Tom Ntej Kev Loj Hlob

1. ** Kev xa khoom tshiab **: Kev tsim kho thaj chaw (suav nrog iiontoophoresis technology) lossis nqus tau hmoov av.

2. ** Kev kho caj ceg

3. ** Daim Ntawv Thov Kev Kho Mob Precision **: Tus Kheej Cov Tshuaj Txhuam Tshuaj Them Khoom Siv raws li tus neeg Gh Privion Txawv.

### xaus

Cov lus qhuab qhia, raws li kev ua tau zoo ntawm ghrh, tau nthuav nws cov ntawv thov kev txhim kho los ntawm kev txhim kho kev txhim kho. Los ntawm qhov yooj yim acetate kom sib xyaw ua cov ntaub ntawv ceev ceev-tso tawm, nws cov kev faib tawm thiab kev ua tau zoo tau muab cov kev xaiv thiab tsis yog kev kho mob. Nyob rau hauv lub neej yav tom ntej, nrog kev nce qib ntawm kev xa khoom thev naus laus zis thiab molecular engineering, sermorelin yuav tsum ua lub luag haujlwm ntau dua hauv cov tshuaj kho qhov tseeb.

Txhawb txoj kev them nyiaj

 

 

Peb txhawb ntau txoj kev them nyiaj

 

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Cim npe nrov: 99% ntshiab sermorelin hwm zoo peptide peptide 2mg / vial, Suav teb hwm zoo peptide 2mg / vial tuam ntxhab, cov chaw muag khoom, Hoobkas