Lub hauv paus rau phau ntawv
Cov khoom lag luam
#### *** {1. overtview thiab tom qab **
** N-Acetyl Epitalon Sib Raug Zoo ** yog tus niam txiv epithon ** lossis ** Ala-Acetylation ** (Acetylation ** (Acetylation **) (Kev noj mov ntawm C-Terminal Carboxylic Acid Group), kev ua haujlwm ruaj khov thiab kev tshawb fawb ntawm lub twj tshuaj uas tiv thaiv kev laus thiab kev tiv thaiv kev tiv thaiv cell}
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#### ** {{2.} tus qauv tshuaj thiab hloov kho qeb 4
##### *** 1. qauv yooj yim **
- ** TSEEM CEEB TSHEEJ: ala-Glu-asp-asp-gly (molecular hnyav: ~ 390 teev: .
- ** Hloov cov yam ntxwv ":
- ** N-acetylation **: Cov amino pab pawg ntawm n-terminal alanine (ala) tau hloov los ntawm cov pab pawg acetyl (CH₃CO-), uas txo cov pab pawg acetyl (CH₃CO-), uas txo cov pab pawg acetyl (CH₃CE-)
- ** C-amidation **: Cov Carboxylic acid pawg ntawm C-Terminal Glycine (Gly) hloov pauv los ntawm CarboxypePetidase {}}
##### ** {2. cov qauv kev faib tawm **
Raws li cov qauv hloov kho, EpiCeson derivatives tuaj yeem muab faib ua:
- ** Kev hloov kho ib zaug **: Tsuas yog N-acetylation lossis C-Kev Noj Qab Haus Huv (xws li N-acetyl Epitalon lossis Epitalon Txaus siab) .
- ** Ob chav kho kom haum ob npaug **: Kev noj khoom haus tib lub sijhawm (Kuv .} {{2 {{.
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#### ** {{3. lub cev thiab tshuaj lom neeg **
##### ** {1.} cov pob hluav taws xob yooj yim **
- ** Molecular cov mis **: C₁₈h₂₇n₅o₉ (yuav tsum tau xam raws li kev hloov kho tshwj xeeb).
- ** Molecular hnyav **: Txog ** {{{490-510 da ** (tus nqi tseeb yuav tsum tau lees paub los ntawm huab hwm coj spectrometry) .
- ** Solubility **:
- ** DEJ solubility **: Muaj pes tsawg leeg (xav tau cov kua txiv tsis muaj zog lossis ultrasound-pab cuam tshuam) .
- ** organic daws **: soluble hauv dmo thiab dmf, insoluble nyob rau hauv tsis-polar solvents (xws li ether).
- ** STABLY **:
- ** Thermal Stability **: Lub sijhawm ntev ntawm -20 degree; yooj yim rau kev thuam ntawm chav sov, yuav tsum tau qhuav los ntawm lub teeb .
- ** PE Phemitivity ": Nyob ruaj khov hauv cov photy ntawm 4-7, muaj zog acid / puag mob ua rau hydrolysis.
##### ** {2.} Ntsuas cov yam ntxwv **
- **HPLC purity**: >95% (C18 rov qab ib theem chromatography, gradient elulation) .
- ** Massures Spectrometry Cov yam ntxwv **: Esi-MS qhia [M + H] ⁺ ncov, txuam nrog theoretical molecular hnyav.
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#### ** {4. xim thiab tsos **
- ** Solid xeev **: Dawb rau off-dawb Lyophilized hmoov (thaum siab purity) .
- ** Solub xim **: tsis muaj xim thiab pob tshab (ph tsis muaj xim), yog cog qoob loo), yog yellowing yuav qhia oxidation lossis impurities .
- ** Caw cov ntsiab lus **:
- ** Purity (xws li cov khoom lag luam oxidation) yuav ua rau muaj xim daj me ntsis .
- ** Cia tej yam kev cia khoom **: Lub teeb lossis kub ua kom nrawm nrawm nrawm nrawm thiab sib sib zog nqus cov xim.
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#### ** {{{5. biological zoo thiab cov haujlwm **
##### ** {1. anti-anti-anti-anti-anti-anti-anti-anti-anti-antiing **
- ** Telomerase kev ua kom zoo **: ncua kev ncua rau kev ua kom luv luv los ntawm kev sim telcraitase transcriptase (tert) hais.
- ** Cell Lub Neej Txuas Ntxiv **: Ntev lub ntsej muag Fibroblast ncig ua si hauv ib qho hauv cov qauv vitro {}}
##### ** {2. antioxidant thiab anti-inflammatory "
- ** ROS scavening **: Inhibits mitochondrial oxidative oxidative ntxhov siab thiab txo MDA (Malondivdehyde) Qib.
- ** NF-κb txoj hauv kev inhibkition **: txo qhov kev tso tawm ntawm cov khoom siv hluav taws xob (xws li} {2} {{4 {4
##### ** {3.} kev tiv thaiv kab mob **
- ** thymus ua haujlwm zoo dua **: Txhawb nqa Cell txawv thiab txhim kho cov tsiaj tiv thaiv kab mob ntawm cov tsiaj laus {}}
##### ** {4. metabolic cov kev cai **
- ** SIFT1 ua haujlwm **: Simulates cov nyhuv ntawm calorie kev txwv thiab txhim kho cov piam thaj thiab lipid metabolism hauv.
##### *** 5. neuroproction **
- ** UPREGULULULULULULULULULULULULULULULULULULULULULULULATION ntawm neurotrophic yam khoom **: tej zaum yuav txhim kho kev txawj ntse kev txawj ntse.
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#### ** {{6.} cov chaw thov **
##### ** {1. kev tshawb fawb **
- ** Kev Tshawb Fawb Kev Laus Txheej Txheem 4: Siv rau telomere muaj cov qauv thiab epigenetic kev coj ua qauv {}}
- ** Kev tsim tshuaj yeeb **: Siv raws li kev ua yeeb yam los ua kom ua kom cov tshuaj tiv thaiv kev laus {}}
##### ** {2. preclinical kev tshawb fawb **
- ** Tsiaj txhu tsiaj **: ntev lifespans ntawm cov nas thiab txhim kho cov kab mob muaj hnub nyoog (xws li osteoporosis).
##### ** {3. tshuaj pleev ib ce thiab cov tshuaj ua haujlwm rau **
- ** Kev tawm tsam cov khoom siv laus tawv nqaij **: Daim ntawv thov kev sib tw yuav txo cov tawv nqaij ua kom tawv nqaij {}}
- ** Cov tshuaj kho rov ua dua tshiab **: ua ke nrog kev kho mob qia los txhawb cov ntaub so ntswg kho kom zoo}}}
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#### *** {{7. synthesis thiab kev tswj hwm zoo **
##### ** {1. synthesis txheej txheem **
- ** SCET THEEM SYSTEMISIONIS (SPPPS) **: FMOC / T-Bu lub tswv yim, ua leiently txuas cov amino acids.
- ** PURIFORATION PEPS **: HPLC npaj, ion txauv cov chromatography rau tshem tawm impurities.
##### ** {2. Cov Qauv Tswj Xyuas Zoo **
- ** IDE **: Pawg Tshaj Tawm Loj (MS), Nuclear Sib Nqus Revelonance (NMR) .
- ** HPLY Nrhiav tau **: HPLC ntau dua los yog sib npaug ntawm 98%, residual cov kuab tshuaj raws li iih cov qauv.
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#### ** {8. kev nyab xeeb thiab kev sib tw **
- **Toxicity data**: No significant acute toxicity was observed in animal experiments (LD₅₀>1000 mg / kg) .
- ** Cov nyom **:
- ** Membrane permeability **: Ib tug cab kuj (xws li Liposomes) yuav tsum tau txhim kho lub xov tooj ntawm tes permeability.
- ** Cov ntaub ntawv ntev ntev **: Cov ntaub ntawv muaj cov kws kho mob ntau dua los txheeb xyuas kev nyab xeeb .
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#### ** {{9.} yav tom ntej Outlook **
- ** Kev ua kom zoo rau cov txheej txheem ": Tsim cov kev ua kom loj hlob uas nkag rau cov ntshav lub hlwb (xws li Palmationlation Kev Hloov Kho) {}}}
- ** POV THAWJ KOM ZUS Kev Kho Mob **: Ua ke nrog NAD + Progursors (xws li NMN) rau kev ua haujlwm .
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### ** Xaus **
N-acetyl Epitalon Qhov kev tshawb fawb tseem ceeb rau kev hloov kho hluavtaws thiab muaj kev nce qib ntawm kev hloov kho lub neej zoo nkauj ntev ntev yog qhov tsim nyog saib rau {}}
Txhawb nqa txoj kev them nyiaj thiab tiv tauj peb
Txhawb txoj kev them nyiaj
Peb txhawb ntau txoj kev them nyiaj
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Cim npe nrov: 99% ntshiab n-acityl Epitalon Txaus siab hwm zoo peptide 5mg / vial, Suav teb tau hwm peptide 5mg / vial tuam ntxhab, cov chaw muag khoom, Hoobkas
