Lub hauv paus rau phau ntawv
Cov khoom lag luam
#### qhia
Delta Tsaug Zog-Inducing Peptide (Dsip) yog ib zaj nkauj neuroive peptide muaj 9 amino acids. Nws tau raug cais thawj zaug thiab pom los ntawm cov khaub lig sebrospinal kua hauv xyoo 1977 thiab tau muaj npe rau nws lub peev xwm los txhawb qeeb qeeb qeeb qeeb qeeb qeeb qeeb qeeb qeeb qeeb qeeb. Ntxiv rau kev khiav tawm pw tsaug zog, DSIP tseem muaj neuroProtective, antioxidant, thiab cov kev cai metabolic ua haujlwm. Kab lus no yuav siv cov DSIP thiab nws cov derivatives los ntawm cov kev faib tawm ntawm cov qauv ntawm cov qauv, cov yam ntxwv xim, qhov zoo thiab cov ntawv thov.
### 1. Cov qauv kev faib tawm thiab cov yam ntxwv ntawm DSIP
### 1. ** Hom khoom ntuj (ntuj) **
- ** Tus yam ntxwv tsim qauv **:
Cov txheej txheem yog ** TRP-Gly-Gly-As-as-as-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly-GLU-GLU-GLU-GLU-GLU) thiab xws li TRP).
- ** Lub cev thiab tshuaj lom neeg **:
- **Solubility**: Easily soluble in water (>1 {0 mg / ml) thiab polar solvents (xws li DMOPS), ruaj khov hauv pH 7.0 tsis.
- ** STABLY **: Yooj yim tshwm sim los ntawm kev tiv thaiv (ib nrab-lub neej ntawm li 15 feeb), xav tau qhov kub ({}} degree) cia.
- ** Xim **: Cov khoom ntshiab yog xim dawb lossis tawm-lyophilized hmoov.
- ** ** Zoo **:
- Muaj kev lom zem biocompatibility high, tsis muaj qhov pom tseeb toxicity.
- Kev koom nrog ncaj qha ntawm kev pw tsaug zog-tsa lub voj voog, ntshiab mechanism ntawm kev nqis tes ua.
- ** Cov kev txwv tsis pub noj **:
Cov metabolism ceev hauv lub cev, cov thawj coj nquag; Lub cev tsis muaj zog permbrane permeability, txwv daim ntawv thov nyob rau hauv nruab nrab lub paj hlwb.
#### 2. ** Synthetic hloov DSIP analogs **
Los ntawm kev hloov kho tshuaj lom neeg los txhim kho kev ruaj khov, ntev ib nrab lub neej lossis txhim kho Bioavailability, lawv feem ntau muab faib ua cov subcategories hauv qab no:
##### ** (1) Cyclic DSIP **
- ** Kev hloov kho txheej txheem ":
Cov saw hlau peptide yog cyclized los ntawm kev qhia txog kev cuam tshuam cov ntawv phem lossis cov ntawv cog lus sawv cev, xws li Cyclization ntawm C-Terminus thiab N-Terminus.
- ** Lub cev thiab tshuaj lom neeg **:
- ** STABLY **: Txhim kho ntau yam tsis kam ua rau enzymatic degradation (ib nrab-lub neej txuas ntxiv rau ob peb teev).
- ** Solubility **: qis me ntsis qis dua tej yam ntuj, cov mis yuav tsum tau ua kom zoo dua qub (xws li ntxiv cov kuab tshuaj).
- ** Xim **: muaju dawb, tsis muaj qhov sib txawv tshwj xeeb los ntawm cov hom ntuj.
- ** ** Zoo **:
- POLONG Lub sijhawm siv tshuaj thiab txo cov zaus ntawm kev tswj hwm.
- Txhim kho qhov muaj peev xwm nkag mus rau cov ntshav-lub hlwb.
##### ** (2) D-amino acid hloov DSIP **
- ** Kev hloov kho txheej txheem ":
Hloov cov l-amino acids nrog d-configuration (xws li D-ala hloov L-Ala) los txo cov enzyme lees paub.
- ** Lub cev thiab tshuaj lom neeg **:
- ** Qhab tshib **: Plasma stability yog txhim kho los ntawm {{1} {1 zaug.
- ** Solubility **: Zoo ib yam li hom ntuj, cov dej solubility zoo.
- ** Xim **: Cov hmoov dawb, uas tej zaum yuav daj me ntsis vim kev hloov kho.
- ** ** Zoo **:
- Txhim kho kev tiv thaiv kom muaj kev cuam tshuam, tsim nyog rau kev tshawb fawb txog qhov ncauj.
##### ** (3) lipid-hloov DSIP **
- ** Kev hloov kho txheej txheem ":
Txuas cov noob fatty acid chains (xws li palmosic acid) nyob rau thaum xaus ntawm peptide saw los txhim kho membrane permeability.
- ** Lub cev thiab tshuaj lom neeg **:
- ** Solubility **: Lipid Solubility yog txhim kho, thiab liposomes lossis nanoparticles tuaj yeem ua.
- ** Qhab **: Ib nrab-lub neej nyob rau hauv cov ntshav yog ncua rau {2}} teev.
- ** Xim **: Vim yog lipid Cheebtsam, nws yuav yog mis nyuj dawb.
- ** ** Zoo **:
- Txhim kho kev hloov dua siab tshiab lossis cov ntshav ntawm lub hlwb ua tau zoo, haum rau cov thawj coj hauv zos (xws li kev hloov pauv rau thaj chaw).
### 2. Ua haujlwm cais tawm thiab cov txiaj ntsig pleiottropic
### 1. ** Cov kev cai pw tsaug zog DSIP **
- ** QAUV muaj nuj nqi **:
Ua kom lub cev sib xyaw ua ke, txhawb nqa Delta Wave (qeeb qeeb) pw tsaug zog) pw tsaug zog, thiab txhim kho insomnia thiab circadian atherosclerosity.
- ** Kev kuaj xyuas cov txiaj ntsig **:
Piv nrog tsoos sedatives, nws tsis muaj kev quav ntxiv thiab kev pw tsaug zog tom ntej tsaug zog.
### 2. ** Neuroproppective Dsip dsip derivatives **
- ** ** FUNTICE txuas ntxiv **:
Txo Cerebral Ischemia lossis Alzheimer Kev Puas Tsuaj Xwm Los ntawm cov radicals dawb thiab inhhiting neuroinflamic (xws li regulating -6).
- ** Tus Sawv Cev Hloov Kho **:
Antioxidant pawg (xws li glutathione) conjugated DSIP kom txhawb nqa dawb radical tsis muaj peev xwm.
#### 3. ** Kev tswj hwm kev cai DSIP **
- ** ** MECHCHISHIOR kev txiav txim **:
Kev tswj hwm cov tshuaj insulin rhiab thiab lipid metabolism ntsig txog cov noob (xws li PARp), txhim kho cov qauv metabolic ntawm cov rog thiab cov qauv ntshav qab zib.
- ** Thov thov kom muaj peev xwm **:
Ua ke nrog GLP -1 analogs los txhim kho dual-phiaj metabolic syndrome tshuaj.
### 3. Kev Ntsuam Xyuas Lub Cev thiab Tshuaj Txhuam Hniav
### 1. ** Qhov hnyav molecular thiab cov qauv teeb tsa **
- ** Nees DSIP **: 849.88 da, muaj 3 tus nqi tsis zoo (asp, Gluc), isoelectric point ≈ 4.5.
- ** Hloov kho cov derivatives **: Molecular hnyav hnyav li 900-1500 da, coj tus cwj pwm sib txawv vim muaj pab pawg hloov kho.
### 2. ** Solubility thiab Tsim Kev Loj Hlob **
- ** DEJ SOLUBILY **: HOM> Cycluized hom> Lipidated hom.
- ** Daim ntawv npaj npaj **
#### 3. ** Kev Nyab Xeeb thiab Kev Cia Khoom **
- ** Qhov kub thiab txias rhiab ": kev poob haujlwm poob<10% when stored at 4℃ for 1 week, stable for more than 1 year at -20℃.
- ** Cov photosensitivity **: Nws raug nquahu kom khaws cia hauv qhov tsaus ntuj, tshwj xeeb tshaj yog derivatives muaj trp yog nquag rau photooxidation.
### 4. Cov xim muaj cim thiab tswj hwm zoo
- ** Daim duab DSIP thiab ntau tshaj plaws lossis tawv nqaij dawb, tsis muaj qhov tseem ceeb xim txawv thaum muaj ntau dua lossis sib npaug ntawm 95%.
- ** Qhia tshwj xeeb hloov kho cov txiv neej **:
- ** Fluorescented Dsip ** (xws li Fitc Sau Npe): Daj lossis Ntsuab Hmoov.
- ** HLAU GROX ** (xws li Cu-DSIP): tej zaum yuav tshwm sim xiav (tooj liab ion chelation).
- ** IGGURURURER COMPER **: Oxidation lossis cov khoom tsis muaj kev cuam tshuam yuav ua rau mob daj, thiab HPLC yuav tsum saib xyuas kev ua yeeb yam.
### 5. Daim Ntawv Thov Cov Lus Qhia thiab Yav Tom Ntej
#### 1. ** Teb Kho Mob **
- ** Pw tsis muaj teeb meem **: kev loj hlob ntawm cov tshuaj tsuag qhov ntswg lossis cov ntaub ntawv sau tseg.
- ** Cov kab mob neurodegenerative kab mob **: Lub hom phiaj xa khoom (xws li exosomes loaded nrog DSIP).
#### 2. ** Tshuaj pleev ib ce **
- ** Kev tiv thaiv cov khoom xyaw laus **: Siv antioxidant muaj nuj nqi, ntxiv rau anti-wrinkle essence.
#### 3. ** Cov cuab yeej tshawb fawb **
- ** ** Sau npe DSIP **: Siv rau cov chaw ua hauj lwm tau txais thiab kev tshawb nrhiav txoj hauv kev.
#### 4. ** Cov nyom thiab cov zeem muag **
- ** ** QHIB LUB LWJLLENCLENC **: Kev loj hlob ntawm lub hlwb-hom phiaj Nanocarrers.
- ** Ua tus-ua haujlwm ntev **: Polyethylene Glycol (Peg) kev hloov kho kom txuas ntxiv mus ncig ncig.
### xaus
Dsip yog ib qho meptide meptide, thiab nws cov duab ntuj daim ntawv thiab hluavtaws derivatives muaj lawv tus cwj pwm hauv cov qauv, khoom thiab kev siv. Los ntawm kev daws teeb meem thiab kev hloov kho, DSIP yuav tsum ua lub luag haujlwm tseem ceeb hauv kev mob neuroscience, cov kab mob metabolic thiab tshuaj kho tus kheej. Kev tshawb fawb yav tom ntej yuav tsum tau tsom rau kev txhim kho kev ruaj khov, kev ua kom zoo dua cov kev hloov pauv thiab nthuav dav nws lub peev xwm.
Txhawb nqa txoj kev them nyiaj thiab tiv tauj peb
Txhawb txoj kev them nyiaj
Peb txhawb ntau txoj kev them nyiaj
Tiv Tauj Peb
Koj tuaj yeem tiv tauj peb ntawm Whatsapp, Telegram, Gmail, Proton Xa Ntawv, thiab lwm yam.
Tiv Tauj Peb tam sim no los ntawm email
Cim npe nrov: 99% DSIP ntshiab zoo peptide 2mg / vial, Suav 99% DSIP zoo tshaj plaws Peptide Lestion Zoo Peptide Peptive Peptive Peptive Pepters 2mg / vial tuam ntxhab, cov chaw muag khoom, Hoobkas
