Peptides ss -31 10 mg CAS: 736992-21-5

SS-31 (tseem hu ua MitoSNO lossis Elamipretide) yog ib qho me me molecule peptide compound uas belongs rau mitochondrial tsom cov tshuaj. Nws txhim kho mitochondrial muaj nuj nqi los ntawm kev tsom mus rau mitochondrial membrane, tshwj xeeb tshaj yog nyob rau hauv lub zog metabolism thiab oxidative kev nyuaj siab teb nyob rau hauv hlwb. SS-31 ntseeg tau tias txhim kho mitochondrial muaj nuj nqi, txo oxidative kev puas tsuaj, thiab yog li txhim kho cell noj qab haus huv.

### lub cev thiab tshuaj lom neeg:

Ss -31 yog peptide composed muaj ntawm 9 amino acids. Nws muaj cov qauv tshuaj lom neeg uas yooj yim dua thiab cov dej-soluble thiab lipid-soluble. Nws tuaj yeem nkag mus rau hauv lub cell membrane thiab zoo lub hom phiaj mitochondria. Nws cov tshuaj lom neeg lub npe yog ** D-Arg2, {}} [d-ser, d-ser] {9 {} hloov chaw **. Lub tshuab ua haujlwm ntawm ss -31}} Feem ntau nyob ntawm nws lub hom phiaj tsim thiab tshuaj tiv thaiv muaj peev xwm ntawm mitochondria.

### Main Functions:

1. **Improve mitochondrial function**: SS-31 can bind to the inner membrane of mitochondria, improve the membrane potential of mitochondria, thereby promoting ATP generation and reducing oxidative stress.

2. ** Kev tiv thaiv kab mob antioxidant **: Nws tuaj yeem txo cov khoom siv dawb ntawm cov dawb radicals, txo cov kev ntxhov siab cell tshwm sim los ntawm oxidative kev ntxhov siab, thiab tiv thaiv cov hlwb los ntawm kev laus lossis kev ua haujlwm.

3. ** Tiv thaiv lub plawv thiab cov leeg hlwb **: ss -31 Tau kawm txog cov kab mob plawv, thiab muaj peev xwm pab kab mob plawv los ntawm MitochonderTs.

### ntau thiab siv:

SS-31 feem ntau yog siv hauv kev tshawb fawb soj ntsuam hauv daim ntawv txhaj tshuaj lossis kev tswj hwm qhov ncauj. Feem ntau cov koob tshuaj raug kho raws li tus neeg mob tus mob, txoj kev kho mob thiab cov tsos mob tshwj xeeb. Cov kev tshawb fawb tau pom tias qhov ntau npaum li cas ntawm SS -31 feem ntau yog nyob nruab nrab ntawm 1-10 mg / kg lub cev hnyav, tab sis cov koob tshuaj tshwj xeeb yuav tsum tau ua raws li tus kws kho mob cov lus qhia. Nws yog siv los kho ntau yam kab mob ntsig txog kev ua haujlwm tsis zoo ntawm mitochondrial, xws li kab mob plawv, kab mob hauv lub paj hlwb, kab mob metabolic, thiab lwm yam.

### Ib nrab-life thiab pharmacokinetics:

Ss -31} muaj luv luv ib nrab-lub neej, feem ntau 1 txog 2 teev. Vim nws lub cev me me molecular hnyav thiab zoo bioavailability, nws tuaj yeem faib tawm thiab ua tau sai sai thiab nws kuj yuav tsum tau tswj hwm cov nyhuv.

### Cycle thiab Cov Nyias:

Cov txiaj ntsig kho mob ntawm SS-31 feem ntau tshwm sim nyob rau lub sijhawm luv, tshwj xeeb tshaj yog tom qab mob hnyav lossis raug mob, thiab tuaj yeem txo cov tsos mob sai sai los ntawm kev ua haujlwm tsis zoo ntawm mitochondrial. Hauv daim ntawv thov mus ntev, SS-31 pab kom ruaj khov lossis txhim kho cov teeb meem kev ua haujlwm mitochondrial cuam tshuam nrog kev laus thiab cov kab mob metabolic. Nws lub voj voog kev kho mob txawv nyob ntawm tus neeg mob tus mob, thiab nws yuav tsum tau siv tsis tu ncua rau lub lis piam lossis ntau lub hlis txhawm rau tswj cov nyhuv.

### Kev Tshawb Fawb Kev Tshawb Fawb thiab Kev Thov:

Clinically, SS -31 yog tam sim no nyob rau hauv kev sim tshuaj, feem ntau yog siv los kho cov kab mob plawv (xws li lub plawv tsis ua hauj lwm, rov qab los tom qab myocardial infarction), cov kab mob neurodegenerative (xws li Alzheimer's disease, Parkinson's disease), thiab lwm yam. SS-31 pab qeeb qhov kev loj hlob ntawm cov kab mob no thiab kho cov ntaub so ntswg ua haujlwm rau qee yam los ntawm kev txhim kho mitochondrial muaj nuj nqi thiab txo qhov tsim ntawm cov dawb radicals hauv hlwb.

### Kev phom sij thiab cov kev mob tshwm sim:

Ss -31}} puas yog feem ntau suav tias yuav muaj kev nyab xeeb, tab sis kuj tseem muaj qee cov kev mob tshwm sim, suav nrog:

1. **Cov tshuaj tiv thaiv hauv zos**: me ntsis liab, o, mob thiab lwm yam tsis xis nyob yuav tshwm sim ntawm qhov chaw txhaj tshuaj.

2. **Cov tshuaj tiv thaiv tsis haum**: Qee tus tib neeg yuav muaj kev fab tshuaj rau SS-31, tshwm sim ua pob liab liab, khaus, thiab lwm yam.

3. "Kev nyab xeeb ntawm kev tshawb fawb ntev **: Txij li kev siv cov kev siv tau, yog qhov kev nyab xeeb ntawm kev kawm ntev, yog li nws yuav tsum tau siv nrog kev ceev faj Cov.

Hauv cov ntsiab lus, SS -31, raws li cov tshuaj tiv thaiv mitochondrial, muaj cov txiaj ntsig ntawm kev txhim kho mitochondrial muaj nuj nqi, tiv thaiv oxidation thiab kev tiv thaiv ntawm tes, thiab tau qhia txog qee yam kev ua tau zoo hauv kev tshawb fawb soj ntsuam, tab sis tseem xav tau kev tshawb fawb ntxiv thiab tshawb xyuas ntxiv.

Ss -31 (tseem hu ua Elamipretide) yog cov pa roj mitochondrial, txhawb nqa cov nqaij me me thiab tiv thaiv cov ntaub so ntswg los ntawm oxidative kev puas tsuaj. Nws cov kev ua tshuab ntawm kev ua yog feem ntau los ntawm kev ua yeeb yam ntawm tus ncej puab ntawm cov khoom siv oxype, Ros), txhim kho mitochondgen hom oxygen, thiab yog li tiv thaiv cov hlwb thiab cov ntaub so ntswg.

### 1. **Cov pejxeem**

SS-31 feem ntau yog siv rau cov neeg hauv qab no:

- ** Cov neeg mob nrog cov kab mob plawv **: Xws li lub plawv tsis ua haujlwm, inechemental plawv, thiab lwm yam kab mob no feem ntau cuam tshuam nrog mitochondction kev ntxhov siab thiab oxidative kev puas tsuaj puas tsuaj. Ss -31}} tuaj yeem pab qeeb qeeb ntawm tus kab mob los ntawm kev txhim kho mitochondrial muaj nuj nqi.

- ** Cov neeg mob uas muaj kab mob neurological**: xws li Parkinson's disease, Alzheimer's disease, thiab lwm yam, cov kab mob no feem ntau nrog mitochondrial dysfunction. SS-31 tuaj yeem txo cov tsos mob los ntawm kev txhim kho mitochondrial kev noj qab haus huv ntawm paj hlwb.

- ** Cov neeg mob nrog cov kab mob metabolic ": Xws li cov ntshav qab zib, tshwj xeeb tshaj yog cov teeb meem ntawm kev tsis taus mitochondrial muaj nuj nqi ntsig txog ntshav qab zib. Ss -31} pab txhim kho cov metabolism hauv nruab nrab.

- ** Kev laus thiab cov kab mob ntsig txog kev laus **: Thaum lub sijhawm kev laus, kev ua haujlwm mitochondrial poob qis thiab oxidative kev nyuaj siab nce. SS-31 tuaj yeem pab ncua cov kev hloov pauv ntawm lub cev muaj hnub nyoog.

- **Cov kab mob ntsig txog leeg**: Piv txwv li, mitochondrial myopathy, SS-31 pab txhim kho cov neeg mob lub cev muaj peev xwm los ntawm kev txhim kho mitochondrial kev ua haujlwm ntawm cov leeg nqaij.

### 2. ** Nws ua haujlwm li cas **

Ss -31} Ua haujlwm tsuas yog los ntawm kev sib tw sab hauv membrane ntawm Mitochondria, ua si txoj haujlwm hauv qab no:

- ** Txo cov oxidative kev nyuaj siab **: ss -31 txo cov cim oxypef ntawm mitochondgid

- ** Txhim kho mitochondrial membrane muaj peev xwm**: SS-31 tuaj yeem txhim kho mitochondrial membrane muaj peev xwm, txhawb ATP synthesis, thiab nce cell zog.

- ** Tiv thaiv mitochondria **: Nws tuaj yeem txhim kho cov qauv mitochondrial, txo cov mitochondrial membrane rupture, thiab tiv thaiv mitochondria los ntawm kev puas tsuaj.

- **Anti-apoptotic effect**: Los ntawm kev tswj hwm apoptosis-txog txoj hauv kev hauv mitochondria, SS-31 tuaj yeem txo tus nqi ntawm cell apoptosis, yog li ncua cov ntaub so ntswg poob thiab puas.

### 3. **Kev siv thiab siv**

Kev siv thiab ntau npaum li cas ntawm SS-31 yuav txawv nyob ntawm seb qhov xwm txheej tshwj xeeb thiab cov hom phiaj kho mob. Feem ntau pom zoo siv thiab ntau npaum li cas muaj xws li:

- ** Daim ntawv foos tshuaj **: ss -31 yog feem ntau yog siv nyob rau hauv daim ntawv ntawm kev txhaj tshuaj, thiab kuj tseem siv tau qee cov chaw kuaj mob lossis kev kho mob).

- ** koob txhaj tshuaj**: Cov koob tshuaj pom zoo rau cov neeg laus feem ntau yog 1-2 zaug hauv ib hnub, thiab ib koob tshuaj feem ntau yog nyob nruab nrab ntawm 1-2 mg. Cov koob tshuaj tshwj xeeb yuav tsum tau hloov kho raws li tus neeg mob qhov xwm txheej tshwj xeeb, xws li qhov hnyav, kab mob hnyav, thiab lwm yam.

- ** COG COG NTXIV *** Kev kho mob yuav txawv nyob ntawm hom kab mob thiab cov hom phiaj kev kho mob. Muaj qee kis, siv tau kev siv sijhawm ntev, thaum nyob hauv lwm tus, nws yuav yog kev kho mob luv luv.

### Notes:

1. ** Kev phiv zoo **: ss -31 Feem ntau muaj cov kev mob tshwm sim tsawg dua, mob me me lossis liab ntawm qhov chaw siv tshuaj.

2. ** Tus neeg mob tau paub tseeb rau cov khoom tsis haum rau cov khoom xyaw ntawm cov khoom xyaw ntawm cov khoom siv tshuaj, lossis qee yam kev sib cuam tshuam yeeb tshuaj, nws yuav tsum zam.

3. ** Kev siv sijhawm ntev ": Kev tshawb fawb txog kev ua kom ntev ntev yog tseem niaj hnub. Txawm hais tias cov ntaub ntawv kuaj ntxov qhia tias nws muaj kev nyab xeeb thiab ua tau zoo, tshwj xeeb kev ua tau zoo ntev thiab kev nyab xeeb yuav tsum tau lees paub ntxiv.

Nyob rau hauv luv luv, SS -31, raws li ib tug tshiab peptide tshuaj, feem ntau relieves ntau yam kab mob cov tsos mob uas muaj feem xyuam rau mitochondrial dysfunction los ntawm kev txhim kho mitochondrial muaj nuj nqi, tshwj xeeb tshaj yog nyob rau hauv lub plawv, paj hlwb thiab kab mob metabolic. Thaum siv nws, nws yog ib qho tsim nyog los kho qhov ntau npaum li cas thiab kev kho mob raws li tus kws kho mob cov lus qhia.

SS-31 (tseem hu ua Elamipretide) yog peptide compound uas feem ntau siv los kho cov kab mob ntsig txog mitochondrial dysfunction. Nws ua haujlwm ntawm mitochondrial membrane los txhim kho kev noj qab haus huv thiab kev ua haujlwm ntawm mitochondria, yog li muaj kev cuam tshuam zoo rau ntau yam teeb meem kev noj qab haus huv. SS-31 tau kawm dav dav rau cov kab mob plawv, kab mob neurodegenerative, thiab lwm yam kab mob ntsig txog oxidative stress thiab mitochondrial puas.

### Cov txheej txheem tseem ceeb ntawm kev ua ntawm SS-31:

SS -31 yog ib qho me me molecule peptide uas tuaj yeem xaiv khi rau mitochondrial membrane thiab txhim kho mitochondrial muaj nuj nqi. Nws ua haujlwm los ntawm cov txheej txheem tseem ceeb hauv qab no:

1. "antioxidant nyhuv **: ss -31 tuaj yeem txo cov kev puas tsuaj ntawm tes los ntawm oxidative kev ntxhov siab. Oxidative kev nyuaj siab yog qhov tseem ceeb ntawm cov kab mob tseem ceeb hauv ntau cov kab mob, thiab lwm yam kev tiv thaiv hlwb, thiab lwm yam.

2. **Kev txhim kho ntawm mitochondrial membrane muaj peev xwm**: SS-31 tuaj yeem txhim kho qhov muaj peev xwm gradient hauv mitochondria, uas yog ib qho tseem ceeb rau kev ua haujlwm ntawm mitochondria. Los ntawm kev rov ua kom cov mitochondrial membrane muaj peev xwm, SS-31 pab kom mitochondrial zog ntau lawm thiab optimize cellular metabolism.

3. **Txhim ATP synthesis**: Mitochondria yog lub zog ntawm cov hlwb, thiab ATP (adenosine triphosphate) yog lub hauv paus ntawm lub zog hauv hlwb. SS-31 txhim kho mitochondrial muaj nuj nqi thiab nce ATP synthesis, yog li txhawb kev ua haujlwm ntawm cov hlwb.

4. ** Txo Mitochondrial kev puas tsuaj **: ss -31 paab, olidative kev raug mob, thiab lwm yam), ncua kev tuag thiab kev laus.

### cov ntawv thov kev kho mob ntawm ss -31:

Kev tshawb fawb ntawm SS-31 qhia tau hais tias nws muaj peev xwm kho tau ntau yam kab mob, tshwj xeeb tshaj yog nyob rau hauv cov kab mob uas cuam tshuam nrog mitochondrial dysfunction.

#### 1. ** Kab mob plawv**

SS-31 ntseeg tau tias muaj txiaj ntsig zoo rau cov hlab plawv. Nws pab txhim kho lub zog metabolism thiab kev ua haujlwm ntawm cov hlwb myocardial, yog li nws muaj peev xwm ua rau cov kab mob xws li mob plawv tsis ua haujlwm thiab mob plawv ischemic.

- **Lub plawv tsis ua hauj lwm**: Cov kev tshawb fawb tau pom tias SS-31 tuaj yeem txhim kho lub zog metabolism ntawm myocardial hlwb, txo cov tsos mob ntawm cov neeg mob plawv tsis ua hauj lwm, thiab txhim kho kev tawm dag zog.

- **Ischemia-reperfusion raug mob**: SS-31 tuaj yeem txo cov kev ntxhov siab oxidative tsim los ntawm lub plawv thaum lub sij hawm ischemia-reperfusion, txo cov cell puas, thiab txhim kho lub plawv ua haujlwm.

### 2. ** Cov Kab Mob NeeDegenerative **

Cov kab mob neurodegenerative, xws li Alzheimer tus kab mob (Ad) thiab Parkinson tus kab mob (Pd), feem ntau nrog mitochondrial kawg. Cov kws kho tshuab ntawm kev ua ntawm ss -31 ua rau nws xaiv tau kev kho mob.

- **Alzheimer's disease**: SS-31 tau qhia txog lub peev xwm los txhim kho kev txawj ntse hauv cov qauv tsiaj thiab tuaj yeem ua rau qeeb ntawm tus kab mob los ntawm kev txo qis oxidative kev nyuaj siab thiab kev puas tsuaj mitochondrial.

- ** Parkinson tus kab mob **: Hauv Parkinson tus kab mob, ss {1}} Kuv tuaj yeem ua lub luag haujlwm zoo ntawm cov mitochondrial ua haujlwm ntawm dopamine num.

#### 3. **Muscle degenerative kab mob**

Hauv cov kab mob ntawm cov leeg nqaij, xws li cov leeg nqaij dystrophy (Duchenne cov leeg nqaij dystrophy) lossis lwm hom nqaij leeg, mitochondrial tsis ua haujlwm kuj yog ib qho tseem ceeb ntawm cov kab mob pathological. SS-31 tuaj yeem pab kho cov kab mob no los ntawm kev txhim kho mitochondrial.

- **Duchenne Muscular Dystrophy**: Cov kev tshawb fawb tau pom tias SS-31 tuaj yeem txhim kho cov leeg nqaij thiab ua haujlwm thiab ua kom cov leeg mob qeeb hauv cov neeg mob Duchenne leeg nqaij dystrophy.

#### 4. ** Ntshav Qab Zib **

Cov neeg muaj ntshav qab zib feem ntau muaj cov haujlwm tsis txaus ntseeg Mitochondrial, tshwj xeeb tshaj yog nyob rau hauv cov ntsiab lus insulin tsis kam thiab txo cov kev ua haujlwm ntawm lub cell ua haujlwm. Ss -31 Tau qhia cov peev xwm hauv kev tshawb fawb los txhim kho pancreatic bancreatic bora cell mitochondrial muaj nuj nqi thiab nce insulin tso pa tawm.

- **Kev Kho Mob Ntshav Qab Zib**: SS-31 tej zaum yuav muaj txiaj ntsig zoo rau kev tswj ntshav qab zib los ntawm kev txhim kho insulin rhiab heev thiab txhim kho mitochondrial muaj nuj nqi.

#### 5. **Cov Kab Mob Laus thiab Degenerative**

Nrog lub hnub nyoog, kev poob qis hauv mitochondrial muaj nuj nqi tuaj yeem ua rau muaj kev noj qab haus huv ntau. Raws li mitochcondrial tiv thaiv, SS -31 muaj peev xwm ua kom qeeb cov txheej txheem kev laus thiab txhim kho cov tsos mob ntawm cov kab mob degenerative.

- **Kev laus**: SS-31 tuaj yeem pab qeeb cov txheej txheem kev laus thiab txhim kho tag nrho cov haujlwm ntawm lub cev los ntawm kev ua kom cov cell aging, txo qhov mob thiab oxidative puas tsuaj.

### Lwm cov txiaj ntsig zoo ntawm SS-31:

- ** anti-inflammatory nyhuv **: ss {2}} tuaj yeem pab tau cov kab mob los ntawm cov lus teb tsis ntev.

- ** Txhim kho kev ua kis las **: txij li ss {{1} Yuav muaj cov txiaj ntsig zoo ntawm kev txhim kho kev ua kis las thiab cov leeg ua kom muaj zog.

- **Kev tiv thaiv daim siab**: Kev tshawb fawb tau pom tias SS-31 tuaj yeem tiv thaiv daim siab ntawm qee yam teeb meem thiab tej zaum yuav muaj txiaj ntsig zoo rau cov kab mob siab (xws li daim siab rog, thiab lwm yam).

### Kev Tshawb Fawb thiab Kev Nyab Xeeb:

Ss -31} Tau qhia kev nyab xeeb thiab muaj kev mob tshwm sim hauv kev sim tshuaj. Txawm li cas los xij, nws txoj kev nyab xeeb ntev thiab cuam tshuam tseem xav tau cov ntaub ntawv cov kws kho mob ntxiv.

### cov ntsiab lus:

SS-31, raws li peptide compound nrog antioxidant, tiv thaiv inflammatory thiab mitochondrial kev ua haujlwm txhim kho, tau pom tias muaj peev xwm kho tau ntau yam kab mob ntsig txog mitochondrial tsis ua haujlwm. Nws muaj kev tshawb fawb dav dav hauv ntau qhov chaw xws li kab mob plawv, kab mob neurodegenerative, ntshav qab zib, thiab kev laus. Nrog rau kev nkag siab ntxiv ntawm nws cov txheej txheem, SS-31 yuav dhau los ua ib qho tseem ceeb ntawm kev kho mob rau ntau yam kab mob.

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Cim npe nrov: peptides ss -31 10 mg CAS CAS: {}} mepts} mg Cas: {} Cov neeg tsim khoom, cov chaw tsim khoom, Hoobkas