Hauj lwm lawm

Kev tsis

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peptides

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Cov khoom lag luam

# ** Kev tsom xam cov kab ke ntawm CJC {{}}} Tsis muaj DAC 5mg + ipa cia ntawm 5mg ua ke peptide **

## ** {{1. Kev faib tawm thiab Txheej txheem cej luam **

### ** 1.1 Kev faib tawm ntawm Peptide Tshuaj **

CJC {-1295 (tsis muaj DAC) thiab IPA (iShanorelin) yog ob qho hluav taws xob peptigemues (GHS) {1}.

- ** CJC -1295}}}} Tsis muaj DAC **: Ib qho kev hloov kho ghrh ghrh analog uas ua kom zais pa taws rau hauv anterior pituitary .

- ** IPA (IPAMORELIN) **: Kev nthuav dav hluavtaws tso tawm peptide (GHS kev txhawb nqa

Kev sib xyaw ntawm ob tug neeg nyob rau ib tug ** synergistically txhim kho peptide mis **, uas yog tsim los ua kom tiav GHS-r txoj kev) .

## ** {{2. Tus qauv tshuaj thiab cov khoom siv dag zog "

### ** 2.1 Tshuaj lom neeg ntawm CJC -1295 tsis muaj dac **

- ** Cov mis molecular **: C₁₆₅h₂₆₇n₄₉o₄₄

- ** Molecular hnyav ** txog 3367.8 da

- ** Cov qauv nta **:

- nws muaj 30 amino acid seem thiab muaj cov ntsiab lus tseem ceeb ntawm ntuj GHRH ({2}.

- Nws tsis muaj tshuaj muaj kev sib cav sib luag (DAC) thiab muaj ib nrab-lub neej (li 30 feeb rau 1 teev).

- ** Solubility **: Nws yog yooj yim soluble hauv dej los yog qaug zog acidic tsis (ph} 4.0-6.0 nws tau pom zoo kom npaj .

- ** STABLY **: Yuav tsum tau muab khaws cia rau hauv tub yees (2-8} degree) thiab thim tawm kom tiv thaiv kev ua kom tsis txhob ua rau.

### ** 2.2 Tshuaj Tshuaj ntawm IPA (ipamorelin) **

- ** Cov mis molecular **: C₄₅h₅₅n₁₁o₆

- ** Molecular hnyav **: kwv yees li 902.0 da

- ** Cov qauv nta **:

- ib qho Pentapeptide (5 amino acids) nrog kev ua ntu zus aib-nws-d -2- nH₂ .

- Muaj cov amin amino acids (xws li aib, d -2-}} nal) kom txhim kho metabolic ruaj khov {3}

- ** Solubility **: Yooj yim soluble hauv dej los yog tsis muaj zog alkaline tov (ph} 1 .

- ** STABLY **: Puas tuaj yeem khaws cia ntawm -20℃rau siv nws li ntawm 24 teev hauv kev daws teeb meem {}}

### ** 2.3 xim thiab tsos **

- ** CJC {{{{}}} Tsis muaj DAC **: Cov hmoov dawb lossis tawv dawb-qhuav hauv lub siab lub xeev {}}

- ** IPA **: Cov khoom ntshiab yog dawb crystalline hmoov .

- ** Tom qab sib tov **: Kev daws tsis muaj xim thiab pob tshab, yam tsis tau raug tshem tawm lossis cov khib nyiab {}}

## ** {{{{3. Cov Khoom Muag Khoom Siv Hluav Taws Xob thiab Syneroistic Zoo **

### ** 3.1 Mechanism ntawm Kev Ua **

- ** CJC -1295 Tsis muaj Dac **:

- khi rau pituitary ghrh recept, ua kom ua adenylate cyclase, acthates gh synthesis thiab pulsatile tso .

- Tsis muaj DAC kev hloov kho, zam kev zais cia ntawm GH, thiab txo cov kev mob tshwm sim (xws li insulin tsis kam) .

- ** IPA **:

- Ua kom GHS-R1S-R1SORS, txhim kho kev ua haujlwm ntawm hypothalramamic kev loj hlob muaj teeb meem "ingping hormones

### ** 3.2 Cov nyhuv synergistic **

- ** Pulse Gompion **: Kev sib xyaw ua ke ntawm ob can tuaj yeem simulate lub ntuj GH}}}}}} .

- ** DOSE-YOOJ YIM TXOJ CAI **: Kev sim ua yeeb yam hais tias kev sib xyaw ntawm CJC {2} ipa cia ntawm {{} lub sij hawm siv .

## ** {{4. chaw kuaj mob thiab qhia **

### ** 4.1 Kev Kho Mob **

- ** Kev loj hlob medone tsis txaus (GHD) **: Siv rau kev kho mob GHD hauv cov neeg laus thiab cov menyuam.

- ** kev tawm tsam kev laus thiab kev sib tw metablivkas **: Txhim kho cov leeg nqaij, cov tawv nqaij elastic thiab tawv nqaij to taub g g-{axis {{4 4}}

- ** POSTOperionative Rov Qab **: Ua kom nrawm qhov ua kom zoo kho thiab cov ntaub mos kho kom zoo .

### ** 4.2 Kev Ua Si thiab Ua Si **

- ** Cov leeg nce thiab poob phaus thiab cov rog rog **: GH txhawb nqa protein synthesis thiab rog decomposition, haum rau cov neeg ncaws pob thiab lub cev ua haujlwm .

- ** Kho kev sib koom tes **: Txhim kho kev sib koom tes kev noj qab haus huv los ntawm i6-1-}}}}}.

## ** {{5. Qhov zoo thiab cov kev txwv thiab

### ** 5.1 qhov zoo **

- ** Ib nrab-lub neej sib piv **: Ib nrab-lub neej ntawm CJC-1295 (tsis muaj DAC) yog qhov haum rau kev sib xyaw ua ke.

- ** Kev nyab xeeb loj **: DAC dawb tsim cov kev mob cuam tshuam nrog kev zais cia gh expion (xws li Edema, Carral Qhov Syndrome) .

- ** Tus nqi-ua tau zoo dua **: Kev kho mob 5MG yog qhov tsim nyog rau kev kho lub sijhawm luv luv thiab kev lag luam nruab nrab, thiab nws txoj kev lag luam zoo dua li kev npaj ntev tshaj plaws.

### ** 5.2 kev txwv **

- ** TXHAJ TSHUAJ TIV THAIV **: Vim tias luv luv ib nrab-lub neej, 1-2 subcutaneous kev txhaj tshuaj yuav tsum muaj txhua hnub.

- ** Cov lus teb sib txawv **: GH Secetion cov lus sib txawv yuav txawv nyob ntawm cov hnub nyoog, poj niam txiv neej thiab lub hauv paus loj.

## ** {6.} kev nyab xeeb thiab cov kev mob tshwm sim **

- ** Cov kev mob tshwm sim tshwm sim **: liab thiab o ntawm qhov chaw txhaj tshuaj, kev mob siab rau mob taub hau, mob pob txha mos.

- ** Cov phom sij loj heev **

- ** Cov teeb meem me me ": contraindicated rau cov neeg mob uas muaj cov qog, thiab cov tsis haum rau peptides.

## ** {{7. Npaj thiab siv cov lus pom zoo **

- ** Xaiv koob tshuaj xyuas ** **

- ** Npaj txoj kev **:

1. re} reconste lub lyophilized hmoov nrog 1-2 ml ntawm cov dej tsis huv rau kev txhaj tshuaj.

{{02. maj mam tig thiab sib tov kom tsis txhob muaj kev sib daj sib ceg uas yuav ua rau peptide saw breakage {}}

- ** Cia tej yam kev cia khoom **: Cov hmoov tsis muaj zog yuav tsum tau muab tso rau ntawm lub teeb, thiab kev rov ua kom pom zoo tau siv nyob rau hauv 24 teev.

## ** {{{8. Tshawb nrhiav kev vam thiab yav tom ntej cov lus qhia **

- ** Kev txhim kho kev ua haujlwm ntev ntxiv **

- ** SISSED MORTISED **: Txhim kho cov ntshav-lub hlwb peptifying peptive saw thiab ncaj qha rau hypothalamus.

- ** Kev kho kev kho mob **

## ** Xaus **

Kev sib xyaw ntawm CJC {{}} Tsis muaj DAC thiab cov kev tshawb fawb zoo dua qub, thiab kho tau ntau yam kev ua kom zoo dua qub siv .