Viagra (Sildenafil Citrate) Raws Powder CAS:171599-83-0

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Viagra (lub npe scientific: ** Sildenafil citrate **) yog tshuaj siv los kho txiv neej erectile kawg (ED, feem ntau hu ua impotence). Sildenafil yog Ameslikas tau tsim los ntawm Pfizer ua tshuaj noj lub qhov ncauj, feem ntau yog nyob rau hauv daim ntawv ntawm ** sildenafil citrate **. Nws pab cov txiv neej ua tiav thiab tswj txoj kev erection los ntawm inhibiting ib qho enzyme hu ** pde5 (phosphodiesters hom 5) ** txhawm rau txhim kho ntshav ntws mus rau tus qau.

### *** Volramra (sildenafil citrate) hmoov hmoov **

Raw hmoov yog hais txog cov khoom siv raw uas tsis tau ua tiav ntawm cov tshuaj, uas feem ntau yog siv rau kev npaj ntau lawm, tsim qauv los yog rau kev tshawb fawb thiab kev sim. Rau cov hmoov nyoos ntawm Sildenafil Citrate, nws feem ntau yog cov hmoov dawb lossis dawb crystalline hmoov, uas yog siv los ua cov khoom siv raw hauv cov txheej txheem tsim tshuaj feem ntau.

### ** Lub cev thiab tshuaj lom neeg **:

- ** Tshuaj npe **: Sildenafil Citrate

Cov mis mos molecular **: C22H30N6O4S

- Molecular Luj: 474.58 g/mol

- ** Tshav **: Dawb los yog ze li dawb crystalline hmoov

- ** Solubility **: Sildenafil muaj cov solubility tsawg hauv dej, tab sis tuaj yeem yaj tau zoo hauv cov kuab tshuaj cawv xws li ethanol.

- ** Melting point **: Txog 185 degree

Sildenafil raws li cov tshuaj nquag ntawm cov tshuaj feem ntau muaj nyob hauv nws daim ntawv ntsev kom zoo thiab ruaj khov, uas yog qhov ua kom haum rau kev nqus cov ntaub ntawv ntawm qhov ncauj.

### *** Cov Cuab Yeej Siv Hluav Taws Xob thiab Cov Tshuab **:

Lub ntsiab lus tseem ceeb ntawm kev ua ntawm Sildenafil yog kom nce cov kev xav ntawm CGMP (cyclic guanosphaate) hauv lub cev los ntawm kev cuam tshuam ** PDE5 (phosphodiester types 5) **. CGMP yog tus yuam sij molecule hauv cov leeg nqaij kom txaus thiab nce cov ntshav ntawm cov leeg ntshav, yog li nce cov ntshav ntawm cov leeg ntshav, yog li los ntawm kev ua kom muaj kev pab rau cov txiv neej tau thiab ua kom muaj kev txhim kho kom ua rau muaj kev sib deev.

Ib qho ntxiv, Sildenafil kuj tseem siv tau los kho cov hlab ntsws vim tias nws dilates cov hlab ntshav thiab txo ntshav siab rau hauv lub ntsws.

### ** DOSAGE **:

Rau cov neeg laus, ib txwm noj ntawm Sildenafil yog raws li hauv qab no:

- ** Muab tshuaj txheem ** ** Feem ntau pib nrog 50 mg, coj los hais txog, txog 30 feeb mus rau 1 teev ua ntej kev sib deev.

- ** Cov koob tshuaj ntau tshaj **: Yuav tsum tsis pub tshaj 100 mg ib hnub twg. Cov koob tshuaj tuaj yeem hloov kho raws li tus neeg mob cov lus teb thiab kam rau ua. Cov koob tshuaj nquag yog 50 mg lossis 100 mg.

- ** O ** Tsawg kawg nkaus koob **: Hauv qee cov neeg mob, tshwj xeeb tshaj yog cov neeg laus lossis cov uas muaj lub siab thiab raum tsis sib xws, nws yuav pib nrog 25 mg.

Txog kev kho mob ntsws ntawm kev mob ntsws, tshuaj yuav txawv, feem ntau 20 mg peb zaug.

### ** Ib Nrab-Lub Neej **:

Lub ** ib nrab-lub neej ** ntawm Sildenafil yog kwv yees li ** 4 teev **. Qhov no txhais tau tias tom qab kev siv cov tshuaj uas xav tau hauv cov ntshav yuav poob mus rau ib nrab ntawm nws qhov tseem ceeb tom qab txog 4 teev. Qhov ntev ntawm ib nrab-lub neej yog cuam tshuam los ntawm ntau yam, xws li tus neeg lub siab metabolism ua haujlwm, seb lwm cov tshuaj siv tau siv tib lub sijhawm, thiab lwm yam tshuaj thiab lwm yam.

### ** Bioavailaby **:

Qhov ** qhov ncauj bioavailability ** ntawm Sildenafil yog kwv yees li 40% **. Qhov no txhais tau hais tias txawm hais tias feem ntau ntawm cov tshuaj nkag mus rau hauv lub plab zom mov, tsis yog tag nrho cov tshuaj tuaj yeem ncav cuag lub cev. Kev noj zaub mov tuaj yeem ua rau qeeb nws qhov nqus, tshwj xeeb tshaj yog cov khoom noj muaj roj tsawg tuaj yeem ncua nws qhov pib ua haujlwm.

### ** Lub sijhawm thiab sijhawm ua haujlwm **:

- ** ONSET **: Sildenafil feem ntau pib ua haujlwm li ntawm 30 feeb rau 1 teev tom qab kev tswj hwm qhov ncauj.

- ** Duration **: Cov tshuaj lub sijhawm ua tiav yog kwv yees li ntawm 4 txog 6 teev, thiab cov kev sib txawv tshwj xeeb (xws li qhov hnyav, hnub nyoog, thiab lwm yam). Feem ntau, thaum lub sijhawm no, tus neeg mob muaj peev xwm ua tiav thiab tswj xyuas erection thaum kev sib deev.

### ** Cov metabolism thiab ua kom zoo nkauj **:

- ** Metabolism ": Sildenafil yog metabolized los ntawm cytochrome p450 enzymes (tshwj xeeb yog cyp3A4) hauv nws cov metabolites nquag.

- ** SUDCRETION **: Silddenafil thiab nws cov metabolites tau tawm hauv cov zis. Kwv yees li 80% yog tawm hauv cov zis, thiab cov seem tau ua tiav hauv cov quav.

### ** Kev phiv thiab kev pheej hmoo **:

Sildenafil yog cov tshuaj pov thawj hauv kev kho mob uas feem ntau muaj kev nyab xeeb, tab sis tuaj yeem ua rau qee qhov kev mob tshwm sim, tshwj xeeb tshaj yog thaum noj ntau dhau. Cov kev mob tshwm sim muaj xws li:

- mob taub hau

- Facial flushing

- Mob plab

- Qhov muag plooj plooj lossis tsis muaj xim tsis pom kev (feem ntau yog ua kom pom tseeb li Cyan pom kev)

- Nasal congestion lossis mob khaub thuas

**Kev mob tshwm sim hnyav** (tsawg dua):

- Ib qho erection inction (erection kav ntev tshaj 4 teev) yog hu ua ** invoog **, uas tuaj yeem ua rau kev puas tsuaj yog tias tsis kho kom sai.

- Cov teeb meem plawv, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj kab mob plawv, yuav tsum tau siv ceev faj thaum siv Sildenafil.

- Hypotension, tshwj xeeb tshaj yog thaum siv nrog cov tshuaj nitrate.

### **Contraindications thiab ceev faj**:

1. **Cov neeg mob uas muaj kab mob plawv**: Sildenafil yuav tsum tsis txhob siv yog tias tus neeg mob noj tshuaj nitrate (xws li cov siv los kho angina) vim tias qhov sib xyaw ua ke ntawm ob tuaj yeem ua rau cov ntshav qis.

2. **Cov neeg mob uas muaj kab mob siab thiab lub raum tsis txaus**: Sildenafil metabolism feem ntau nyob ntawm daim siab, yog li cov neeg mob siab tsis txaus yuav tsum tau txo cov koob tshuaj. Cov neeg mob lub raum tsis txaus yuav tsum tau kho cov koob tshuaj raws li qhov xwm txheej tshwj xeeb.

3. ** Lwm cov tshuaj sib txuas lus siv tshuaj, feem ntau yog qee cov tshuaj antifungal, tshuaj tua kab mob, thiab qee cov tshuaj antihyptensive. Cov neeg mob yuav tsum siv nws raws li tus kws kho mob.

### ** Xaus **:

Viagra (sildenafil citrate) yog cov tshuaj feem ntau siv los kho txiv neej erectile kawg. Nws pab cov txiv neej tau txais thiab tswj kev erection los ntawm kev nce ntshav ntws mus rau tus qau. Nws cov hmoov nplej nyoos feem ntau siv hauv kev siv tshuaj yeeb los yog ntsuas thiab muaj cov solubility zoo thiab ruaj khov. Siv yuav tsum muaj kev saib xyuas noj tshuaj, sijhawm ua haujlwm, thiab cov kev mob tshwm sim tshwm sim, tshwj xeeb tshaj yog nyob rau cov neeg mob plawv lossis lwm yam comorbidities.

Viagra (sildenafil citrate) hmoov nplej yog ib qho tshuaj rau kev kho mob erectile kawg (ed) thiab feem ntau yog muag raws li cov tshuaj noj. Nws ib txwm muag nyob rau hauv daim ntawv ntawm daim ntawv ntawm kev ua lag luam, tab sis nws tseem muaj yog hmoov siav hmoov rau kev tsim cov tshuaj. Cov hauv qab no yog cov lus qhia ntxaws ntxaws rau cov neeg siv tau, ua haujlwm ua haujlwm, siv thiab ntau npaum ntawm Sildenafil Raw hmoov:

### 1. ** Cov neeg muaj feem xyuam **

Sildenafil feem ntau yog siv rau cov neeg hauv qab no:

- ** Txiv neej erectile kawg (ED) cov neeg mob **: cov txiv neej uas tsis tuaj yeem tau txais lossis tswj kom muaj erection txaus los ua kom tiav kev sib deev hauv kev sib deev stimulation.

- **Pulmonary arterial hypertension (PAH) cov neeg mob**: Raws li kev qhia ntawm tus kws kho mob, sildenafil kuj tau siv los kho pulmonary arterial hypertension los pab txo cov ntshav siab.

- **Cov kab mob plawv ntsig txog kev sib deev tsis zoo**: Rau kev sib deev tsis ua haujlwm los ntawm cov teeb meem plawv, sildenafil tuaj yeem suav tias yog kev kho mob.

### 2. ** Tus ua haujlwm ua haujlwm **

Sildenafil exert yog nws kho cov nyhuv los ntawm kev txhim kho cov nyhuv ntawm nitric oxide. Cov txheej txheem tshwj xeeb yog raws li hauv qab no:

- ** "Enhibition ntawm PDE5 enzyme (phospheS (phospheterease 5) **: Sildenafil tuaj yeem inhibit cov kev ua si ntawm pde5 enzyme, uas tawg cia cyclic adenosine monophosphate (CGMP). CGMP yog ib qho tseem ceeb molecule uas tswj cov leeg ua kom txaus, tshwj xeeb tshaj yog nyob hauv cov hlab ntsha. Los ntawm kev txwv tsis pub PDE5, Sildenafil tuaj yeem nce qib CGMP, yog li so cov hlab ntsha, thiab pab txiv neej ua tiav kev sib deev.

- ** Zoo raws li kev ua yeeb yam ntawm kev sib deev nyuaj **: Sildenafil tsis yog ua rau erections, nws yuav tsum tau siv nrog kev sib deev los ua cov nyhuv.

### 3. **Kev siv thiab siv**

- ** DOSAGE **: Cov koob tshuaj ntau rau cov neeg laus yog **, uas tuaj yeem hloov kho kom tau ** 25 mg ** lossis ** 100 mg ** nyob ntawm tus neeg qhov cuam tshuam thiab kev ua siab ntev.

- **Yuav ua li cas noj**: Sildenafil feem ntau noj ntawm qhov ncauj li ntawm **30 feeb mus rau 1 teev** ua ntej kev sib deev, nyiam dua ntawm lub plab khoob, vim tias cov zaub mov tuaj yeem ncua cov nyhuv ntawm cov tshuaj. Qhov koob tshuaj yuav tsum tsis pub tshaj **100 mg** hauv 24 teev.

- **Cov koob tshuaj ntau tshaj**: Txhawm rau zam cov kev mob tshwm sim, nws raug nquahu kom noj nws tsis pub ntau tshaj ib zaug txhua 24 teev.

- ** Kho mob ntawm pulmonary blinds (PAH): Rau cov neeg mob kho mob ntshav siab ntsws, qhov ib txwm muaj ** peb zaug ib hnub. Cov koob tshuaj tshwj xeeb yuav tsum tau hloov kho raws li tus kws kho mob cov lus qhia.

### 4. **Kev ceev faj**

- **Kev cuam tshuam tshuaj yeeb**: Sildenafil tej zaum yuav muaj kev cuam tshuam txaus ntshai nrog qee cov tshuaj (xws li nitrates), ua rau muaj ntshav siab sai. Yog li ntawd, cov neeg uas noj cov tshuaj no yuav tsum tsis txhob siv sildenafil.

- ** Cov kev mob tshwm sim**: Cov kev mob tshwm sim feem ntau muaj xws li mob taub hau, lub ntsej muag dej, plab zom mov, qhov muag tsis pom kev, thiab lwm yam. Cov neeg mob yuav muaj kev phiv loj dua xws li lag ntseg, teeb meem plawv, thiab lwm yam. Yog tias muaj xwm txheej ceev xws li mob hauv siab, nyuaj. ua pa, ntev erection (ntau tshaj 4 teev) tshwm sim, nrhiav kev kho mob tam sim ntawd.

- ** Cov khoom siv tsis haum **: Cov neeg mob uas ua xua rau sildenafil lossis nws cov khoom xyaw, lossis cov neeg mob uas siv cov tshuaj uas muaj nitrates yuav tsum zam kev siv.

### 5. ** Siv Sildenafil Raw hmoov **

Sildenafil raw hmoov yog tsuas yog siv nyob rau hauv cov txheej txheem ntau lawm ntawm cov tuam txhab ntau lawm, lossis qee cov xwm txheej uas yuav tsum tau siv cov tshuaj. Rau cov tib neeg, tshwj tsis yog nyob hauv tus kws kho mob, nws tsis pom zoo los yuav cov hmoov uas tsis zoo thiab muab tshuaj rau kev tswj hwm thiab tej zaum yuav muaj kev phom sij kev nyab xeeb.

Viagra (Sildenafil citrate) yog ib qho tshuaj siv dav uas yog siv los kho cov txiv neej erectile kawg (ED), tab sis nws cov kev siv thiab cov teebmeem mus deb dhau qhov ntawd. Raws li cov tshuaj nquag siv tshuaj, sildenafil feem ntau ua haujlwm los ntawm inhibiting ib qho enzyme hu ua phosphodiesterase type 5 (PDE5), yog li txhim kho vasodilation, ua rau cov ntshav ntws mus rau hauv qhov chaw mos, thiab yog li txhim kho kev ua haujlwm ntawm erectile. Sildenafil raw hmoov yog feem ntau siv hauv kev tsim tshuaj thiab muaj ntau yam txiaj ntsig zoo hauv ntau qhov chaw. Nov yog qee qhov txiaj ntsig tseem ceeb ntawm sildenafil raw hmoov:

### 1. **Kev kho mob erectile kawg (ED)**

Qhov kev siv tau zoo tshaj plaws ntawm Sildenafil yog kho txiv neej erectile kawg. Nws relaxes du cov leeg, ua kom cov ntshav ntws mus rau cov txiv neej penpast, thiab pab cov neeg ua kom tau txais thiab txhim kho cov teebmeem ntawm nitric oxide (tsis muaj).

- ** Txhim kho cov ntshav khiav **: Sildenafil txhim kho vasodilation, txhim kho cov ntshav hauv zos, thiab txo cov teeb meem erectile los ntawm cov ntshav tsis zoo.

- ** Txhim kho kev sib deev **: Los ntawm kev txhim kho cov ntshav txaus, sildenafil ua rau cov txiv neej tau txais kev sib deev thaum muaj kev sib deev thaum muaj kev sib deev thaum muaj kev sib deev thaum muaj kev sib deev thaum muaj kev sib deev thaum muaj kev sib deev thaum muaj kev sib daj sib deev

### 2. **Kev kho mob pulmonary arterial hypertension (PAH)**

Sildenafil kuj tseem siv los kho cov kab mob ntshav tawg (PAH), ib qho kab mob uas cuam tshuam rau cov hlab ntshav hauv lub ntsws, ua rau lub siab ua haujlwm nyuaj. Sildenafil ua haujlwm los ntawm kev tshem cov hlab ntshav hauv lub ntsws kom txo cov hlab ntsha thiab txhim kho cov ntshav txaus.

- ** Txo cov hlab ntshav siab **: Sildenafil tuaj yeem txo qhov siab hauv cov hlab ntsws, txhim kho cov pa oxygen, thiab pab txo qis ua pa.

- ** Txhim kho kev ua kom muaj zog ntxiv **: Hauv cov neeg muaj PAH, sildenafil pab txhim kho kev tawm dag zog thiab lub neej zoo.

### 3. ** Txhim kho kev tawm dag zog **

Cov kev tshawb fawb tau qhia tias Sildenafil tuaj yeem pab txhim kho kev ua haujlwm ib ce, tshwj xeeb yog ib ce muaj zog lossis qee qhov teeb meem cardiopulmonary.

- ** Txhim kho cov pa oxygen kom zoo **: Sildenafil dilates cov hlab ntsha thiab txhim kho cov pa oxygen thiab cov as-ham, uas yuav pab tau cov neeg ncaws pob xa cov pa oxygen mus rau cov leeg zoo dua thaum lub zog siv zog, yog li txhim kho kev ua kis las.

- **Kev mob siab rau qhov siab**: Ntawm qhov siab siab, vim yog cov pa nyias nyias, sildenafil tuaj yeem pab txo qis kev mob siab los ntawm kev txhim kho cov ntshav oxygen.

### 4. ** Txhim Kho Lub Plawv Noj Qab Haus Huv **

Sildenafil muaj qee cov txiaj ntsig rau cov hlab plawv, tshwj xeeb tshaj yog rau kev kho mob ntawm qee yam kab mob plawv.

- ** Txhim kho cov txiaj ntsig zoo kawg nkaus **: Sildenafil lub vaseodooth nyhuv pab txo cov haujlwm ntawm lub siab, tshwj xeeb tshaj yog rau cov neeg laus lossis cov neeg mob plawv.

- ** Yuav tawm tsam lub plawv tsis kam **: Qee qhov kev tshawb fawb tau pom tias Sildenafil tuaj yeem txhim kho cov tsos mob tsis ua haujlwm thiab txhim kho cov kev ua haujlwm me me thiab txhim kho cov kev ua haujlwm ntawm lub plawv.

### 5. **Cov nyhuv Antidepressant (muaj peev xwm tshawb fawb qhia)**

Txawm hais tias sildenafil yog Ameslikas tsim los rau kev kho mob erectile kawg, qee qhov kev tshawb fawb tau pom tias nws yuav muaj kev cuam tshuam tsis ncaj rau cov neeg mob kev nyuaj siab. Los ntawm kev txhim kho cov ntshav khiav thiab nce cov pa oxygen mus rau hauv lub hlwb, sildenafil tuaj yeem pab daws cov teeb meem ntawm lub hlwb los ntawm cov ntshav tsis zoo.

- ** Txhim kho kev mob hlwb **: los ntawm kev txhim kho lub dag zog tej yam kev mob, Sildenafil yuav tsis ncaj rau qee qhov kev ntxhov siab ntawm lub hlwb, thiab kev ntxhov siab tshwm sim los ntawm kev tsis xis nyob ntawm lub cev (xws li ed).

### 6. ** Txhawb kev noj qab haus huv endocrine **

Sildenafil kuj muaj peev xwm ua tau zoo rau qee yam teeb meem endocrine. Piv txwv li, Sildenafil yuav muaj kev cuam tshuam rau kev txhim kho qee qib ua txiv neej ua kom muaj kev noj qab haus huv muaj feem xyuam rau kev sib deev cov tshuaj hormones sib deev.

### 7. ** Lwm cov txiaj ntsig zoo **

Qee qhov kev sim tsiaj thiab kev tshawb fawb soj ntsuam tau pom tias sildenafil tuaj yeem muaj lwm yam txiaj ntsig, txawm tias kev tshawb fawb hauv cov cheeb tsam no tseem tab tom ua.

- **Cov teebmeem Antitumor**: Cov kev tshawb fawb ua ntej tau pom tias sildenafil tuaj yeem ua lub luag haujlwm pabcuam hauv kev kho qee yam kabmob, pab txhim kho cov ntshav rau cov qog, yog li cuam tshuam rau kev loj hlob ntawm cov qog nqaij hlav cancer.

- **Neuroprotective teebmeem**: Sildenafil tab tom kawm txog kev kho mob ntawm qee yam kab mob neurodegenerative (xws li Alzheimer's disease), thiab cov txiaj ntsig ua ntej qhia tau hais tias nws yuav muaj qee yam kev tiv thaiv neuroprotective.

### ceev faj rau kev siv:

- ** Cov kev mob tshwm sim **: Txawm hais tias Sildenafil muaj kev mob zoo, nws kuj tseem tuaj yeem siv lub zeem muag, thiab lwm yam yuav cuam tshuam rau cov Cov teeb meem plawv, tshwj xeeb tshaj yog rau cov neeg muaj cov teeb meem tseem ceeb yuav tsum tau siv nrog kev ceev faj.

- ** Kev sib cuam tshuam nrog lwm cov tshuaj **: Sildenafil sib cuam tshuam nrog qee cov tshuaj (xws li cov tshuaj nitrate, qee cov tshuaj tua kab mob), yog li tus kws kho mob yuav tsum tau sab laj ua ntej siv.

### Summary:

Sildenafil (Viagra) tsis yog tsuas yog cov tshuaj classic rau kev kho mob ntawm erectile kawg, tab sis kuj qhia tau tias muaj txiaj ntsig zoo hauv ntau qhov chaw noj qab haus huv. Los ntawm kev txhim kho cov ntshav khiav thiab txo cov ntshav siab hauv lub ntsws kom txhim kho kev ua kis las thiab txhawb kev noj qab haus huv ntawm cov hlab plawv, thaj tsam ntawm daim ntawv thov ntawm sildenafil yog txuas ntxiv mus. Txawm li cas los xij, txawm tias muaj ntau yam txiaj ntsig kev noj qab haus huv ntawm sildenafil, txhua qhov kev txiav txim siab siv cov tshuaj no yuav tsum tau ua raws li kev qhia ntawm tus kws kho mob kom muaj kev nyab xeeb thiab ua tau zoo.

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