Letrozole Raws Powder CAS: 112809-51-5

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Letrozole yog cov yeeb tshuaj tiv thaiv hluav taws xob anti-tshuaj anti-antenogen koom nrog cov tshuaj estrogen-cancen-ender Nws ua haujlwm los ntawm inhibiting qhov kev txiav txim ntawm aromatase, txo cov qib tshuaj estrogen hauv lub cev, yog li tiv thaiv txoj kev loj hlob ntawm cov hlav tshuaj.

### 1. ** ** Cov khoom siv tshuaj thiab lub cev **

- ** Lub npe tshuaj **: Letrozole

- ** Molecular cov mis **: C17H11N5

Molecular hnyav: 285.31 g / mol

- ** ** "Letrozole yog phenylprozole compound nrog nitrogen atom thiab ib lub nplhaib uas muaj ntxhiab nyob rau hauv nws cov qauv tshuaj.

- ** Tswmciab **: Letrozole hmoov yog dawb los yog tawm-dawb, feem ntau yog crystalline hmoov.

### 2. **Mechanism and action**

Lub ntsiab nyhuv ntawm letrozole yog kom txo cov synthesis ntawm estrogen los ntawm inhibiting kev ua si ntawm aromatase. Aromatase yog lub luag haujlwm enzyme rau hloov Androgens hauv estrogens. Los ntawm inhibiting aromatase, letrozole txo qib tshuaj estrogen hauv lub cev, yog li kev loj hlob ntawm estrogen-ranke cancen cancer mis.

### 3. **Dosage and Use**

Cov tshuaj ntsuam xyuas cov tshuaj hauv chaw kuaj mob nyob ntawm qhov teeb meem tshwj xeeb ntawm tus neeg mob, tab sis nyob rau hauv kev kho mob cancer mis, cov koob tshuaj uas muaj:

- ** Muab koob tshuaj rau ** ** Daim Doos qauv **: 2.5 mg txhua lub sijhawm, noj ib zaug ib hnub.

- ** Kev Kho Mob **: Lub voj voog kev kho mob feem ntau yog 5 xyoo, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob qog noj ntshav tom qab yug me nyuam, feem ntau yog siv los tiv thaiv kev mob qog noj ntshav.

Letrozole qee zaum siv los kho lwm yam kab mob (xws li Polycystic Ovary syndrome lossis ntxiv lawm, tab sis nws siv yog tseem tsawg rau kev kho mob cancer.

### 4. ** Pharmacokinetics (ib nrab-lub neej thiab nqus) **

- ** Rho tawm thiab Bioavailability **: Letrozole yog maj mam nqus tau tom qab tswj qhov ncauj, thiab lub qhov ncauj bioavailability yog li 99%. Nws yog ywj siab ntawm cov zaub mov, qhia tias cov nyhuv yog zoo ib yam thaum coj ua ntej lossis tom qab noj mov.

- **Kev faib tawm**: Cov protein khi ntawm Letrozole hauv ntshav yog li ntawm 60-70%. - ** Ib nrab-lub neej **: Letrozole muaj ib nrab-lub neej ntawm li 2 hnub (kwv yees li 48 teev), uas txhais tau hais tias nws yuav siv sij hawm ntev kom tshem tawm ntawm lub cev.

- ** Metabolism thiab kev ua yeeb yam thiab ua kom tiav ** Nws cov metabolism yog qhov qeeb qeeb, yog li nws yuav nthuav tawm hauv lub cev thaum siv ntev.

### 5. ** Lub voj voog ntawm kev nqis tes ua thiab kev ua tau zoo **

- **Cov nyhuv pib**: Cov nyhuv ntawm Letrozole feem ntau tshwm nyob rau hauv ob peb lub lis piam tom qab pib kho, thiab kev siv mus sij hawm ntev tuaj yeem txo cov tshuaj estrogen hauv lub cev.

- ** QIB COG COGREEN **: Letrumically yog siv rau ntau xyoo (piv txwv, kev sib raug zoo rau kev mob cancer mis feem ntau yog {1}} xyoo kawm). Lub sijhawm ntawm nws cov qog tshaj tawm tau cuam tshuam nrog cov yam ntxwv xws li tus neeg mob estrogen qib thiab hom mob cancer.

### 6. ** Kev mob tshwm sim thiab kev pheej hmoo **

Txawm hais tias Letrozole muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav mis, kev siv mus sij hawm ntev kuj tuaj yeem ua rau muaj qee yam kev mob tshwm sim, feem ntau suav nrog:

- ** KUB NYEM **: Cov poj niam, tshwj xeeb tshaj yog cov neeg nyob tom qab lawm, yuav muaj kev kub siab (kub flash) thiab tso tawm cov hws khov kho.

- ** Txo cov pob txha ceev **: Kev siv ntev ntev ntawm Letrozole tuaj yeem ua rau muaj kev pheej hmoo ntawm pob txha vim nws ua rau cov tshuaj estrogen qis.

- ** mob pob qij txha**: Qee cov neeg mob qhia txog kev sib koom tes tsis xis nyob thiab mob.

- ** Teeb meem plawv**: Kev txwv tsis pub ntev ntev ntawm cov tshuaj estrogen tuaj yeem cuam tshuam rau cov hlab plawv thiab ua rau muaj kab mob plawv.

- ** Pastrinesseninal tsis ncaj ncees **: Cov tsos mob xws li xeev siab, ntuav, thiab tsis qab los noj mov.

Cov kev mob tsawg dua muaj xws li daim siab puas, cov tsos mob kev nyuaj siab, thiab lwm yam.

### 7. **Kev kho mob**

Letrozole feem ntau yog siv rau:

- ** Tus mob cancer mis **: Letrozole yog cov tshuaj feem ntau siv, tshwj xeeb hauv kev kho mob estrogen receptor-zoo (ER +) tus mob cancer mis hauv cov poj niam postmenopausal.

- ** Kev kho mob ntxiv lawm tshiav ** Qee zaum siv los ua ovulation, tshwj xeeb tshaj yog nyob rau hauv cov poj niam uas muaj ovary ovary syndrome (pcos), raws li lwm txoj hauv clomiphene.

- **Adjuvant therapy**: Hauv kev kho mob qog noj ntshav ntawm lub mis, Letrozole tuaj yeem siv ua ke nrog lwm cov tshuaj tiv thaiv kev rov tshwm sim.

### 8. **Lwm yam ceev faj**

- **Contraindications**: Letrozole yog contraindicated rau cov poj niam cev xeeb tub thiab pub niam mis vim hais tias nws muaj feem xyuam rau lub fetus thiab me nyuam mos.

- ** Cov kev sib cuam tshuam yeeb tshuaj **: Letrozole yuav cuam tshuam nrog qee cov tshuaj, tshwj xeeb yog cov uas cuam tshuam rau lub siab mob ntsws siv tshuaj (xws li qee yam tshuaj tiv thaiv kabmob ovileptic (tshuaj tua kab mob, tshuaj tua kab mob, thiab lwm yam). Qhia koj tus kws kho mob txog txhua yam tshuaj uas koj tau noj ua ntej siv.

### Cov ntsiab lus

Letrozole yog ib qho zoo aromatase inibase inibitor uas yog dav siv los kho mob cancer mis, tshwj xeeb hauv cov poj niam postmenopausal. Nws ua rau muaj kev loj hlob ntawm cov qog nqaij hlav cancer los ntawm kev txo qis cov qib hauv lub cev, tab sis nws txoj kev ua tau zoo ua rau qee qhov kev mob siab, xws li mob pob txha. Yog li ntawd, cov kev mob tshwm sim, tshwj xeeb hloov hauv cov pob txha ceev thiab plawv kev noj qab haus huv, yuav tsum tau saib xyuas tsis tu ncua thaum siv letrozole.

Letrozole yog ib feem siv profomatase inibitor uas yog dav siv los kho cov tshuaj ntsuab ntawm tus mob cancer, tshwj xeeb yog cov poj niam postmenopausal. Nov yog qee cov ntsiab lus hais txog letrozole cov hmoov nplej siav, suav nrog cov pej xeem siv, ua haujlwm ntawm cov cai thiab ntau npaum li cas.

### 1. Cov neeg nyob ntawm Letrozole

1. **Cov neeg mob cancer mis:**

Letrozole feem ntau siv los kho tus mob cancer mis, tshwj xeeb tshaj yog cov tshuaj estrogen receptor-zoo (ER +) tus mob cancer. Cov tshuaj no feem ntau yog siv rau hauv cov poj niam postmenopausal lossis ua kev kho mob ntxiv tom qab kev phais mob tshem tawm cov qog.

- ** Kev kho tus neeg mob mob cancer uas tau phais mob cancer, ROARDIHACTAPY lossis tshuaj kho mob los txo qhov kev pheej hmoo mob qog nqaij hlav.

- ** Metastatic mis cancer **: Letrozole kuj feem ntau siv los ua kev kho mob rau cov neeg mob cancer mis uas muaj Metastasized.

2. **Polycystic ovary syndrome (PCOS):**

Letrozole kuj tseem siv los kho kev xeeb tub hauv qee tus poj niam, tshwj xeeb tshaj yog cov neeg muaj PCOS. Nws pab txhawb ovulation thiab yog ib qho kev kho tshiab thiab zoo.

3. **Kev tiv thaiv kev kho mob (kev tshawb fawb ib nrab):**

Muaj qee qhov kev tshawb fawb tshawb nrhiav lub peev xwm ntawm kev tiv thaiv kev tiv thaiv rau cov neeg muaj kev pheej hmoo mob cancer mis, tab sis qhov no tseem nyob hauv kev sim hauv kev sim mob theem.

### 2. Yuav ua li cas letrozole ua haujlwm

Letrozole ua haujlwm los ntawm inhibiting aromatase. Aromatase yog tus tseem ceeb enzyme hauv lub cev uas hloov Androgens hauv estrogen. Los ntawm inhibiting aromatase, letroozole muaj peev xwm txo cov qib ntawm cov cuab yeej siv hluav taws xob, tshwj xeeb tshaj yog nyob ntawm qhov kev txiav txim ntawm kev ua ntawm aromatase.

- ** Hauv kev kho mob qog noj ntshav ntawm lub mis**: Estrogen feem ntau txhawb kev loj hlob ntawm qee hom qog nqaij hlav cancer mis. Los ntawm inhibiting cov synthesis ntawm estrogen, Letrozole tuaj yeem txo qhov kev loj hlob thiab kev loj hlob ntawm cov qog nqaij hlav cancer mis.

- **Nyob rau hauv polycystic zes qe menyuam syndrome**: Los ntawm kev txo cov tshuaj estrogen hauv lub cev, Letrozole nkoos pituitary caj pas kom secrete follicle-stimulating hormone (FSH), yog li txhawb kev loj hlob ntawm follicle thiab pab ovulation.

### 3. Kev siv thiab ntau npaum li cas ntawm Letrozole

### 1. ** Kev kho mob cancer mis **

- **Cov neeg laus noj tsis tu ncua**:

- Kev kho mob cancer mis metastatic lossis mob qog noj ntshav thaum ntxov: koob tshuaj feem ntau pom zoo yog 2.5 mg ib hnub ib zaug.

- Adjuvant therapy (xws li tom qab phais): 2.5 mg ib hnub ib zaug, feem ntau yog 5 xyoos, lub sijhawm kho tshwj xeeb yuav tsum tau txiav txim siab raws li tus kws kho mob cov lus qhia.

- ** Kev Siv **: Noj mov, nrog rau zaub mov noj lossis ntawm lub plab khoob, nws raug pom zoo kom coj nws ntawm lub sijhawm ruaj txhua hnub.

### 2. ** ovulation Induction rau Polycystic Ovary syndrome **

- ** DOSAGE **: Cov koob tshuaj ib txwm yog 2.5 mg Ib hnub, kev kho mob yog 5 hnub, feem ntau pib txij thaum lub cev ntas, thiab noj tshuaj mus tas li rau 5 hnub.

- ** Kawm cov txheej txheem kho mob **: Lub sijhawm no, tus kws kho mob yuav saib xyuas cov hauv paus ntawm tus neeg mob cov lus teb thiab kho cov lus teb yog tias tsim nyog.

#### 3. ** Lwm yam taw qhia thiab kev ntsuas tshuaj **

Qhov ntau npaum ntawm Letrozole yuav raug hloov kho raws li tus neeg mob qhov xwm txheej tshwj xeeb, yog li ntawd yuav tsum ua raws li kws kho mob cov lus qhia thaum siv.

### 4. Cov kev mob tshwm sim ntawm Letrozole

Raws li cov tshuaj muaj zog, Letrozole tuaj yeem ua rau qee qhov kev mob tshwm sim. Cov kev mob tshwm sim muaj xws li:

- ** Kub flashes **: Zoo ib yam li cov tsos mob menopausal, nws tshwm sim sai sai ntawm lub ntsej muag thiab kub taub hau.

- **Osteoporosis**: Kev siv mus sij hawm ntev yuav ua rau cov pob txha qis, yog li cov pob txha ceev yuav tsum tau kuaj xyuas tsis tu ncua thaum siv nws.

- ** mob pob qij txha lossis mob leeg **: Cov kev mob tshwm sim no tshwm sim ntau dua thiab tuaj yeem cuam tshuam rau tus neeg mob lub neej txhua hnub.

- ** xeev siab, qaug zog**: Qee cov neeg mob yuav hnov ​​​​mob xeev siab, qaug zog thiab lwm yam tsos mob tsis xis nyob.

- ** Teeb meem plawv**: Qee cov neeg mob yuav ntsib teeb meem plawv xws li ntshav siab lossis dyslipidemia.

**Kev mob tshwm sim hnyav**:

- ** Ntse muaj nuj nqi puas tsuaj **: tsawg tsawg ntawm cov neeg mob me yuav muaj teeb meem rau daim siab thiab yuav tsum saib xyuas lub siab ua ntu zus.

- ** Cov tshuaj tiv thaiv tsis haum **: Yog tias muaj cov tsos mob ua xua xws li pob khaus thiab ua pa nyuaj, tsis txhob siv tam sim ntawd thiab nrhiav kev pab kho mob.

### 5. Ceev faj rau kev siv

- **Cov neeg muaj lub siab thiab lub raum tsis ua haujlwm**: Cov neeg mob lub siab thiab lub raum tsis ua haujlwm yuav tsum siv raws li kev qhia ntawm kws kho mob.

- ** Modrancy thiab Lactation **: Letrozole yog cov tshuaj uas muaj cov kev pheej hmoo rau tus me nyuam hauv plab, yog li cov poj niam ua kom muaj lactating thiab lactating poj niam yuav tsum zam kev siv nws.

- **Kev sib cuam tshuam ntawm cov tshuaj**: Letrozole tuaj yeem cuam tshuam nrog lwm cov tshuaj, tshwj xeeb tshaj yog cov tshuaj hormonal lossis tshuaj tiv thaiv kab mob. Yog li ntawd, koj yuav tsum qhia koj tus kws kho mob thaum siv lwm yam tshuaj.

Feem ntau, Letrozole yog ib qho tshuaj zoo heev, tshwj xeeb tshaj yog nyob rau hauv kev kho mob cancer mis thiab polycystic zes qe menyuam syndrome, tab sis nws cov kev phiv thiab kev ceev faj thaum siv nws yuav tsum tau kho nrog ceev faj.

Letrozole yog ib yam tshuaj uas feem ntau siv los kho mob cancer ntawm lub mis thiab belongs rau chav kawm aromatase inhibitor. Nws ua haujlwm los ntawm inhibiting qhov kev txiav txim ntawm aromatase, txo cov synthesis ntawm estrogen. Estrogen ua lub luag haujlwm txhawb cov qog loj hlob hauv qee hom mob qog noj ntshav mis, yog li Letrozole feem ntau siv los kho cov tshuaj hormone receptor-zoo mob qog noj ntshav mis. Nov yog cov txiaj ntsig ntawm Letrozole:

1. **Kev kho mob ntawm cov tshuaj hormone receptor-zoo mob cancer mis**: Letrozole inhibits aromatase thiab txo cov theem ntawm estrogen hauv lub cev, yog li inhibiting kev loj hlob ntawm cov tshuaj hormone-dependent cell cancer ntawm lub mis. Nws yog feem ntau siv rau cov poj niam postmenopausal los pab txo kev pheej hmoo ntawm mob qog noj ntshav ntawm lub mis.

2. "Kev kho mob cancer mis xwb **: Rau kev phais mob cancer mis, tshwj xeeb yog tom qab tus neeg mob tau cuam tshuam kev tawm tsam thiab kev kho mob.

3. ** Kev kho mob ntxiv lawm tshob (Polycystic Ovary syndrome, pcos hauv cov poj niam) ** tshwj xeeb yog hauv cov neeg mob polycystic ovary syndrome (pcos). Nws tuaj yeem txhawb ovulation thiab yog cov kev kho mob tshiab tshiab uas zoo dua li kev ua yeeb yam tsoostriphene.

4 .: Txo qhov kev pheej hmoo ntawm cov kab mob hormones ntsig txog kev tiv thaiv lossis kho lwm cov tshuaj tua kab mob estrogen hauv lub cev.

5. "Kev siv ceev ntom ntom *: Siv sijhawm ntev ntawm Letrozole tej zaum yuav cuam tshuam cov pob txha ceev, raws li cov qib tshuaj estrogen yuav nce cov kab mob ntawm cov osteoporosis. Txawm li cas los xij, cov kev tshawb fawb tau pom tias kev siv cov tshuaj ua kom zoo-txhim kho cov tshuaj lossis cov tshuaj ntsuab calcium thiab cov vitamin thiab vitamin d ntxiv tuaj yeem ua rau qee qhov kev cuam tshuam no.

6. ** Kev ua kom mob qog noj ntshav **: Ntxiv rau tus mob mis, cov nyhuv anti-antrogen tseem ceeb rau lwm tus neeg estrogen-basent cancer lossis ovarian cancer lossis ivine cancer. Kev tshawb fawb yog tshawb ntxiv nws lub peev xwm nyob rau hauv kev kho mob cancer no.

7. **Qhov zoo tshaj tamoxifen**: Letrozole feem ntau suav hais tias muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav mis dua li tamoxifen (lwm yam tshuaj tiv thaiv estrogen). Tshwj xeeb tshaj yog thaum kho cov poj niam postmenopausal, Letrozole feem ntau zoo dua li tamoxifen.

8. **Kev qoj ib ce thiab kev tswj qhov hnyav**: Qee cov kev tshawb fawb tau pom tias Letrozole tuaj yeem muaj txiaj ntsig zoo hauv kev txo qhov hnyav thiab txhawb cov roj metabolism, tab sis qhov no tseem tsis tau lees paub.

Txawm hais tias cov txiaj ntsig ntawm Letrozole yog qhov tseem ceeb, nws cov kev mob tshwm sim kuj yuav tsum tau muab sau tseg, nrog rau kev mob sib koom tes, txo cov pob txha ceev, kub flashes, hnyav nce, thiab lwm yam. Tsis tas li ntawd, kev siv Letrozole yuav tsum tau ua raws li kev qhia ntawm kws kho mob. , tshwj xeeb tshaj yog thaum siv rau lub sijhawm ntev, kev kuaj xyuas cov pob txha tsis tu ncua thiab daim siab thiab lub raum ua haujlwm tseem ceeb heev.

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