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### Kev Tshawb Xyuas Kev Ntsuas Ntawm Methyltestosterone (MethandRostenolone, Dianabol) Raw Khoom Hmoov

MethandRostenolone (MethandRostenolone), lub npe lag luam ** Dianabol **, yog qhov xwm txheej sib tham hauv thaj chaw ua si kis las thiab tshuaj. Kab lus no yuav ntsuas nws cov yam ntxwv thiab kev tsis pom zoo los ntawm ntau qhov ntev xws li cov qauv tshuaj, kev siv tshuaj hauv paus, kev ua yeeb yam thiab kev coj noj coj ua.

### 1. Cov qauv tshuaj thiab cov synthesis

### 1.1 Tshuaj lom neeg thiab tus lej

Lub npe tshuaj lom neeg ntawm methyltosterone yog ** {{}}}}}}}}}}}}}}}} {{{{} {} {} {{} {} {{ Nws cov qauv kev teeb tsa muaj xws li:

- ** {{17 - methylation **: txhim kho qhov ncauj bioavailability, tab sis nce kev pheej hmoo ntawm hepatotoxicity.

- ** 1, {{4- tus qauv diene **: txhim kho kev muaj suab npe nrog Androgen Receptor (AR) thiab ncua sij hawm ib nrab-lub neej.

- ** C3 KETO GROUP **: khaws cov tub ntxhais ua haujlwm ntawm cov roj ntsha thiab tswj hwm cov nyhuv anabolic.

#### 1.2 cov txheej txheem hluavtaws

Kev lag luam khoom siv ntawm methyltestosterone feem ntau siv ** dehydroepiandrosterone (DHEA) ** raws li cov khoom siv raw thiab ua tiav los ntawm ntau kauj ruam:

1. ** Epoxidation **: DHEA reacts nrog peroxide los ua ib epoxy intermediate.

2. ** Ntiv nplhaib-qhib methylation **: Qhia rau 17 - methyl pab pawg nyob hauv acidic tej yam kev mob.

3. ** Kev hloov kho oxidative **: Kho pab pawg C3 ua haujlwm kom ua cov qauv ua haujlwm kawg.

Tus txheej txheem no yuav tsum muaj kev tswj hwm cov tshuaj tiv thaiv kom tsis txhob tsim cov khoom ntawm cov khoom lag luam.

### 2. Keeb kwm keeb kwm yav dhau los thiab kev txhim kho cov ntsiab lus

#### 2.1 R & D Keeb Kwm

Thaum xyoo 1950, Asmeskas tus kws khomob ** John Ziegler ** Coothing nrog rau cov chaw ua haujlwm, txhawm rau txhim kho cov leeg nqaij, los txhim kho cov leeg nqaij thiab lub zog ntawm cov neeg ncaws pob. Xyoo 1958, Dianabol tau pom zoo los ntawm FDA rau kev kho mob ntawm cov leeg atrophy thiab osteoporosis.

#### 2.2 Golden muaj hnub nyoog thiab muaj kev sib cav

Thaum xyoo 1960 thiab 1970s, Dianabol los ua tus qauv "KUB" rau cov teeb meem ntawm lub cev, tab sis nws cov teeb meem kev ua phem kawg tau nthuav tawm. Thaum xyoo 1970, FDA tshem nws daim ntawv tso cai kho mob thiab tsuas yog siv tau siv tsawg nyob rau qee lub tebchaws.

### 3. Kws ua pharmacological ntawm kev ua

#### 3.1 Anabic Ass

- ** STSEIN SCHTHY SCHTHYRENEST ERHANCEMENCEY **: Txhawb nqa kev ua haujlwm ntawm cov leeg cell ribosome translation los ntawm kev ua kom lub mtor av.

- ** anti-catabolic **: Inhibit cov kev khi ntawm cortisol rau nws cov receptors thiab txo cov leeg nqaij tawg.

- ** NITROGEN Kev Khaws Cia Dua **: Tseev ntawm tes ntawm xov tooj ntawm cov nitrogen tshuav nyiaj thiab txhawb ib puag ncig rau cov leeg kev loj hlob.

#### 3.2 Androgenic kev ua ub no

- ** Receptor Binding **: Lub affinity rau Ar yog li 50% ntawm Testosterone, tab sis ib nrab-lub neej yog txuas rau {}} teev.

- ** Kev ua haujlwm tshwm sim sab hnub nyoog **: Cov koob tshuaj muaj peev xwm yooj yim tuaj yeem ua rau cov tsos mob ntawm hyperandrogenism xws li pob txuv thiab plaub hau hle.

### 4. Daim Ntawv Thov Kev Sau Ntawv thiab cov tswv yim quasy

#### 4.1 Kev Kho Mob (Keeb Kwm)

- ** Siv cov leeg dystrophy **: Kev siv luv luv rau cov leeg muaj cov leeg hauv cov neeg mob cancer lossis HIV HIV.

- ** Osteoporosis **: Txhim kho cov kev pheej hmoo uas txhawb nqa pob txha ceev, tab sis tau hloov vim daim siab lom zem.

#### 4.2 Kev Ua Haujlwm Txhim Kho

- ** Qeeb-lub rooj zaum-chav tsev lub voj voog **: Cov koob tshuaj raug yog {2}} mg ib hnub, nrog lub voj voog ntawm {3}} lub lis piam, feem ntau siv hauv kev sib xyaw nrog cov testosterone.

- ** Kev txhim kho lub zog ": Kev Txhim Kho Lub Sij Hawm luv luv los ntawm kev nce leeg cov leeg nqaij fiber ntau ntawm cov chaw seem thiab kev ua siab ntev.

#### 4.3 Cov Kev Xaiv Niaj Hnub

- ** "prodrugs **: xws li methyl -1- pressosterone (M1T testosterone (uas yog cov pab pawg vim tias lawv lub zog muaj zog.

- ** Xaiv cov kev xaiv tsis muaj suab npe ": Xaiv cov androgen receptor modulators (sarms) sim ua kom muaj kev sib npaug thiab kev nyab xeeb.

### 5. Cov kev cuam tshuam nrog thiab kev pheej hmoo txaus ntshai

#### 5.1 daim siab mus rau

- ** Oural Enzymes **: {{{}} methyl qauv inhibits ci ntsa iab, ua rau muaj kev ntsuas ntxiv.

- ** CHOLESTASIS **: Ib qho tsawg kawg nkaus tab sis muaj peev xwm ua rau muaj kev limhiam uas yuav tsum tau ua rau cov tshuaj.

#### 5.2 endocrine cuam tshuam

- ** HPT AXIS

- ** Tus txiv neej kev txhim kho mis **: aromatization rau estrogen ua kom lub mis ntxuav tes hyperplasia.

#### 5.3 Cov Pheej Yig

- ** LDL / HDL Imbalance **: Txo cov lipoprotein ntau ntom thiab muaj kev pheej hmoo ntawm atherosclerosis.

- ** DEJ THIAB SODAGE LAWM **: Ua rau kev kub siab los ntawm lub renin-angiotensin system.

### 6. Kev cai lij choj thiab kev tswj hwm coj ua

#### 6.1 Kev Tswj Thoob Ntiaj Teb

- ** Tebchaws Asmeskas **: teev nyob rau hauv teem sijhawm III ntawm cov tswj hwm kev ua, muaj yam tsis muaj kev ua txhaum cai.

- ** European Union **: Yuav tsum muaj kws kho mob cov tshuaj, txwv tsis pub siv cov xwm txheej kis las (Wada).

- ** Tuam Tshoj **: Ntau Lawm thiab Muag Khoom yog nruj me ntsis tswj tau raws li kev tawm tsam doping.

#### 6.2 raw khoom hmoov kev ncig

- ** OB UA LAG LUAM TSHUAJ TSHUAJ TSHUAJ TSHUAJ TSHUAJ TSHUAJ TUAV LOS NTAWM AUS POLITY GRACE, nrog cov kev pheej hmoo siab heev (cov neeg deev luag poj luag txiv yog ib qho steroids).

- ** Cov kev pheej hmoo ntawm txoj cai **: Kev txhaum cai ntshuam lossis muaj yuav ua rau raug nplua.

### 7. Xaus thiab kev sib cav sib ceg

Methyltestosterone, raws li thawj qhov hluav taws xob sterthetic, tau nce qib kev txhim kho cov chaw ua si hauv zej zog kom hnyav cov txiaj ntsig "thiab" kev noj qab haus huv ". Kev tshawb fawb niaj hnub tsom rau yuav ua li cas txo cov tshuaj lom neeg los ntawm kev hloov kho txheej txheem (xws li tshem tawm {} Metyl pab pawg) lossis tsim cov kws sau me me. Rau cov tib neeg, nws yog ib qho tsim nyog los paub txog nws rab ntaj ob-sab ntaj sab nraud; Rau tib neeg, nws yog ib qho tsim nyog los ua rau kev saib xyuas thiab kev kawm los txo cov kab lis kev cai ntawm kev ua phem.