Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

raws

product-1400-1400

Cov khoom lag luam

## 1. Cov ntsiab lus

Lidocaine, kev paub txog kev siv tshuaj, kev paub txog kev siv tshuaj Txij li thaum nws thawj cov hluavtaws hauv xyoo 1943, nws tau dhau los ua ib qho ntawm cov feem ntau cov kev ntsuas tshuaj loog hauv cheeb tsam hauv chaw kuaj mob. Nws tus lej cas yog ** {137-58-6}}}}} **, lub cev molecular c₁₄h₂₂n₂o, thiab molecular hnyav yog 234.34 g / mol. Kab lus no yuav ntsuas cov lidocaine API los ntawm ntau qhov ntev, suav nrog kev faib tawm, tshuaj siv tshuaj, cov qauv siv, thiab cov qauv tshuaj zoo.

## 2. Kev faib tawm cov txheej txheem: segmentation raws li kev coj dawb huv thiab siv

Lidocaine APIs tuaj yeem faib ua cov hauv qab no, raws li cov kev coj dawb huv, cov txheej txheem siv ntau dua:

### 1. Kws Kho Mob Qib Lidocaine

- ** tus lej lej **: 137-58-6

- ** Purity txheem **: Ntau dua lossis sib npaug nrog 99.5% (HPLC)

- ** Cov cim qhia tseem ceeb **: Raws li cov kws ua tshuaj nyob hauv Tebchaws Meskas (EP), xws li paperacopoeia (EP)<0.1%), heavy metals (<10 ppm) and microbial limits.

- ** ** Zoo **:

- Siab bioavailability, haum rau kev txhaj tshuaj, thaj ua rau thaj, cream thiab lwm yam kev npaj.

- nruj kev ua raws li cov txheej txheem tswj cov txheej txheem kom ntseeg tau tias muaj kev nyab xeeb.

- High batch-to-batch-batch-batch sib xws, ntsib GMP ntau lawm.

- ** ** Daim Ntawv Qhia Kev Xaiv Tsa **:

- Tshuaj loog hauv zos (xws li kev phais mob, kho hniav, dermatology).

- Antiarhythmic (kev txhaj tshuaj tiv thaiv).

- Qhov mob analgesic (rau qhov mob neuropathic).

### 2. Muaj qib Lidocaine

- ** tus lej lej **: 137-58-6

- ** Purity txheem **: 95% -99%

- ** Cov cim taw qhia tseem ceeb ** Tsom rau kev tsom xam thiab tshuaj lom neeg ruaj khov, nrog qis qis rau microbial txwv thiab tshwj xeeb impurities.

- ** ** Zoo **:

- Nqi-tau zoo, haum rau cov khoom tsis muaj txiaj ntsig.

- Customizable particle loj (xws li micronization).

- ** ** Daim Ntawv Qhia Kev Xaiv Tsa **:

- Cov khoom siv sab nraud (xws li electrode gel).

- Cov tshuaj pleev kom dawb huv (cov khoom xyaw ua si).

- Kws kho tsiaj kom zoo nkauj npaj tau.

### 3. Kev sim kawm qib lidocaine (tshawb fawb)

- ** tus lej lej **: 137-58-6

- ** Purity txheem **: Ntau dua los yog sib npaug rau 99.9% (Pawg Ntau Spectrometry Qib)

- ** Cov cim taw qhia tseem ceeb **: ultra-qis trac impurities (hplc-ms pov thawj), isotope sau npe (xws li xees npe).

- ** ** Zoo **:

- Tsim nyog rau molecular txheej txheem kev tshawb fawb (xws li sodium ion channel kev xam zauv).

- Txhawb PharmacoPicetic (PK / PD) qauv kev txhim kho qauv.

- ** ** Daim Ntawv Qhia Kev Xaiv Tsa **:

- Neuroscience Laboratory (Electrophysiological kev tshawb fawb).

- Daim ntawv txheej txheem tshiab tshiab (Nanocarrier xa khoom).

- Kev Tshawb Fawb Toxicology (Kev Ntsuam Xyuas Kev Taw Qhia Pagwees).

## 3. Tshuaj lom neeg thiab lub cev muaj zog

### 1. Lub cev thiab tshuaj lom neeg

- ** Pom zoo ** ** Hmoov dawb crystalline hmoov, tsw ntxhiab, ntsim me ntsis.

- ** Solubility **: Yooj yim soluble hauv ethanol (1: 1.5), chloroform (1:40), soluble me ntsis hauv dej (1:70, {8}}).

- ** Melting point **: 68-69 degree.

- ** PKA tus nqi **: 7.9 (25 degree), uas ua rau nws ib nrab ntawm lub physiological Ph, uas yog qhov zoo rau cov xov tooj ntawm tes.

### 2. Cov txheej txheem hluavtaws

Txoj kev siv hluavtaws tseem ceeb siv 2, 6- d dimethyline raws li cov khoom pib:

1. ** Cov tshuaj tiv thaiv acylation **: hws nrog chloroacetyl cloride rau daim ntawv {1} 6- dimethylphenyl) acetamide.

2. ** Kev saib xyuas cov tshuaj tiv thaiv **: Hloov chlorine atoms nrog diethylamine nyob rau hauv alkaline tej yam kev mob los tsim cov kev txwv licedine.

3. ** Ua kom zoo **: Recrystallization (ethanol / dej system) lossis kem chromatography purification.

## 4. Lub chaw muag tshuaj kho mob thiab cov ntawv thov kho mob

### 1. Mechanism ntawm Kev Ua

- ** Sodium channel thaiv **: thim rov qab inhibits voltage-gated sodium raws (VGSCS) thiab thaiv cov hlab ntsha) thiab thaiv cov hlab ntsha conduction conduction.

- ** Membrane cov teeb meem ruaj khov **: Txo cov haujlwm ntawm Cardiomyocytes thiab ua kom lub sijhawm ua haujlwm zoo (tiv thaiv kab mob).

### 2. Cov lus qhia tseem ceeb

- ** Kev tshuaj loog hauv zos **: Infiltration tshuaj loog ({}}}}}}}}}}}}}%).

- ** SEPHYTHMIA **: Ventricular Tachycardia (1-3} mg / kg kev txhaj tshuaj / Kg Intravenous txhaj tshuaj).

- ** Tswj Qhov Ntsuas Khoos **: Postherpetic Neuralgia (transdermal thaj 5%).

## 5. Kev tswj hwm kev nyab xeeb thiab kev nyab xeeb

### 1. Cov tsis muaj qhov tsis zoo

| Cov khoom xeem|Kws Tshuaj Qib Kawm (USP)|Muaj Qib Qib Qib Qauv |

|----------------|-------------------|----------------|

| Purity (HPLC)|Ntau dua los yog sib npaug rau 99.5%|Ntau dua los yog sib npaug rau 95% |

| Ya raws (KF txoj kev)|Tsawg dua los yog sib npaug rau {{0}}}. 5%|Tsawg dua los yog sib npaug rau 1.0% |

| Residual Hnyav (GC)|Ua raws li Ich Q3C|Tsis muaj kev txwv meej |

| Cov kab mob endotoxin|<0. 1 EU / MG|Tsis kuaj |

### 2. Kev Nyab Xeeb thiab Cia

- ** Cov ntaub ntawv muaj txiaj ntsig **: cov duab kab ld =459 ml / kg, tsis txhob nqus pa lossis sib cuag nrog cov hlab mis.

- ** ** Stability **: Muab cia rau hauv cov thawv kaw tseg ntawm lub teeb (2-8 degree), siv tau rau 3 xyoos.

- ** Kev thauj mus los tsheb tshwj xeeb **: UN3249 (tshuaj, cov khoom lag luam txaus ntshai hauv Yam 6.1).

## 6. Kev ua lag luam thiab kev tswj hwm cov qauv

- ** Cov khoom lag luam thoob ntiaj teb tuaj rau tus neeg ntiaj teb **: Pfizer, aspen pharapacare, Jiangsu Hlegu Hlgru cov tshuaj, thiab lwm yam.

- ** Qog duab patent **: PENT rau cov tseem ceeb ua ke tau tas sij hawm, tab sis cov ntaub ntawv ntau npaum li cas (xws li Liposomes) tseem muaj kev tiv thaiv.

- ** Kev tswj hwm cov qauv ntxiv **: FDA txhawb nqa cov npav cardiToxicity ceeb toom ntawm cov tshuaj loog hauv zos, thiab EU txhawb nqa cov tshuab loj.

## 7. Kev tshawb nrhiav yav tom ntej

1. ** Lub cev xa khoom **: Tsim cov nanoparticles kom tsawg.

2. ** Ua ke npaj tau **: ua ke nrog epinephrine kom ncua lub sijhawm tshuaj loog (1: 100, {3} recio).

3. ** Kev kho mob ntawm cov kab mob neurological **: Tshawb nrhiav cov kev mob neuromodatory nyob rau hauv epilepy thiab mob ntev.

## Xaus

Cov kev faib tawm multidimensional ntawm Lidocaine API qhia txog nws tus nqi sib tw tag nrho los ntawm kev tshawb fawb kev lag luam. Nrog rau kev txhim kho cov tshuaj kho mob, kev txhim kho ntawm cov kev ua kom siab dawb thiab ua haujlwm tau ntxiv yuav nthuav ntxiv nws cov chaw ua haujlwm ntxiv. Nruam ua kom zoo ntawm cov txheej txheem hluavtaws thiab kev tswj hwm zoo yog tus yuam sij los ua kom muaj kev sib raug zoo thiab kev nyab xeeb.