Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

raws

product-1400-1400

Cov khoom lag luam

### ** 1. Txheej txheem cej luam **

FluoSxosterone (luam lub npe halotestin) yog lub zog hluavtaws Androgen thiab Anabolic Steroid (Aas), tsim los ntawm Pfizer hauv xyoo 1957 thiab pom zoo los ntawm FDA. Ua ib qho kev ua yeeb yam ntawm testosterone, nws cov qauv tshuaj tshwj xeeb muab nws lub qhov ncauj ua kom zoo thiab muaj zog Androgenican cuam tshuam, tab sis nws yog nrog cov kev pheej hmoo siab txaus ntshai. This article systematically describes its chemical properties, pharmacological mechanisms, synthesis processes, application areas, safety and market status.

### ** 2. Tshuaj lom neeg lub zog **

#### ** 2.1 Kev Ntsuas Dua **

- ** tus lej lej **: 76-43-7

- ** Lub npe tshuaj ** 9 -}}} Metherburnrost {} {6}} ib

- ** Cov mis molecular **: C₂₀h₂₉fo₃

- ** Molecular hnyav **: 336.45 g / mol

#### ** 2.2 Cov Qauv Siv Tshuaj **

FluPoxYexus yog raws li cov pob qij txha Androste, thiab cov kev hloov kho tseem ceeb muaj xws li:

- ** {{9 - Txoj Haujlwm Cov tshuaj fluorine atom **: txhim kho androgen receptor affinity thiab ncua metabolism.

- ** {17 - methyl **: txhim kho qhov ncauj bioavailability, tab sis nce kev siab ua kom mob siab.

- ** {{11 - hydroxy **: Yuav cuam tshuam rau kev ruaj khov metabolic thiab kev ua si.

#### ** 2.3 Lub cev thiab tshuaj lom neeg **

- ** Pom zoo **: Dawb rau off-dawb crystalline hmoov.

- ** Melting point **: 240-245 degree (decomposition).

- ** Solubility **: Yooj yim soluble hauv chloroform thiab acetone, me ntsis soluble hauv ethanol, yuav luag insoluble hauv dej.

- ** STABLY **: nkag siab txog lub teeb, yuav tsum tau muab cia kom deb ntawm lub teeb; Yooj yim rau oxidize, yuav tsum tau muaj kev tiv thaiv los ntawm cov roj inert.

### ** 3. Pharmacological khoom **

#### ** 3.1 Mechanism ntawm kev ua **

- ** Androgen Receptor Eponist **: khi rau intracellular cov khoom siv los txhawb cov leeg nqaij, erythropoiesis thiab kev sib deev.

- ** antiesdogen nyhuv **: inhibits estrogen receptor kev ua si thiab yog siv rau kev kho mob cancer mis.

#### ** 3.2 qhia **

- ** Tus txiv neej hypogonadism **: Hloov kev kho mob, koob tshuaj feem ntau 5-20 mg / hnub.

- ** Pallioctive kev kho mob kheesxaws mis **: inhibits cov qog estrogen-rhiab, koob tshuaj} mg / hnub.

- ** APLastic anemia **: Txhawb cov hlwb pob txha hematopoiessis (tam sim no feem ntau hloov los ntawm recombant erhroptoietin).

#### ** 3.3 Pharmacokinetics **

- **Absorption**: Oral bioavailability is >90%, ncav cuag cov tshuaj pleev xim rau hauv 1-2 teev.

- ** Metabolism **: Hydroxylation thiab glucuronidation los ntawm daim siab cyp3A4 enzyme los tsim cov metabolites tsis muaj zog.

- ** ** Ib nrab-lub neej **: Txog 9-10}} teev cov koob tshuaj txhua hnub.

- ** Kev Tshaj Tawm **: Feem ntau ntawm cov zis (60%) thiab quav (40%).

### ** 4. Synthesis cov txheej txheem **

#### ** 4.1 cov kauj ruam tseem ceeb **

1. ** Pib cov khoom **: Dehydroepiandrosterone (DHEA) yog siv los ua cov khoom siv raw.

2. ** Cov tshuaj tiv thaiv fluorinate **: Qhia cov tshuaj fluorine atom ntawm 9 txoj hauj lwm xav tau kev siv HF lossis ERTROLDFUNDOR® ntawm tsawg ({2}} degree).

3. 4. Methylation **: Methylation ntawm 17 txoj haujlwm uas siv iodomethane / sodium hydroxide tej yam kev mob.

4. ** Oxidation thiab Hydroxylation **: {11 - hydroxyl pawg yog oxidganianisms (xws li aspergills (xws li aspergillus niger).

#### ** 4.2 Cov txheej txheem sib tw **

- ** Kev tswj lub storeosectivity ** kom ntseeg tau lub stereoconfiguration ntawm {1}} f thiab {2}} hh.

- ** Purification **: Ntau cov recrystallization lossis chratomographic sib cais yog qhov yuav tsum tau txhim kho qhov kev coj dawb huv (> 99%).

### ** 5. Ua daim ntawv thov **

#### ** 5.1 daim ntawv thov kho mob **

- ** Oncology **: Siv rau cov kab mob cancer mis kom daws cov pob txha thiab qog nqaij hlav.

- ** EPECRINYology **: Kho cov txiv neej qes qes, txhim kho kev sib deev thiab pob txha ceev.

#### ** 5.2 Tsis yog-kho mob **

- ** Kev sib tw kis las **: Vim tias nws txhim kho kev sib zog thiab lub zog, nws tau raug tsim txom, nws tau raug tsim txom lossis lub thawv ntawv thiab tam sim no Wada txwv cov tshuaj.

- ** Kev Tshawb Nrhiav Txoj Kev **: Tshawb Xyuas Cov Me Mekas 9 - Fluoro {2}} Ketone Teb Chaws hauv Cov zis los ntawm GC-MS.

### ** 6. Kev Nyab Xeeb Thiab Cov Kev Mob tshwm sim **

#### ** 6.1 hom phiv **

- ** Hepatotoxicity **: Cholestatic Jaundice, nce lub siab ua kom haum (alt / ast).

- ** Cov kev pheej hmoo ntawm cov kev pheej hmoo **: Ntau LDL, txo HDL, txo qis kev pheej hmoo ntawm atherosclerosis.

- ** ** OPECRINE cuam tshuam ": Txiv neej Kev Tsim Kho Lub Tsib (Estrogen)

#### ** 6.2 Cov Pheej Hmoo Loj Dua **

- ** Kev siv lub siab rau kev siv lub siab tuaj yeem ua rau muaj kev ua kom muaj kev lom zem lossis mob siab rau mob siab (tsis tshua muaj neeg mob siab).

- ** Cov tsos mob hlwb **: nce kev ua phem, hloov pauv hloov ("steroid npau taws").

#### ** 6.3 contraindications **

- Cov poj niam cev xeeb tub (ua rau mob plab masculinization), prostate cancer, mob siab rau siab ntsws thiab raum tsis sib xws.

### ** 7. Kev ua lag luam thiab cov cai **

#### ** 7.1 kev tsim khoom ntawm 7.1 thiab muab khoom **

- ** Rau cov tuam ntxhab loj ": Pfizer (thawj tshawb fawb), Is Nrias teb lub tshav ntuj, thiab qee cov tuam txhab API hauv Suav.

- ** API Cov Qauv Kawm Ntawv **: Sib ntsib USP / EP cov qauv kev coj dawb huv (HPLC Purity ntau dua los yog sib npaug rau 99.5%).

#### ** 7.2 Kev tswj hwm xwm txheej **

- ** USA **: Teem III tswj tshuaj, yuav tsum muaj cov ntaub ntawv.

- ** ** ** ** Thoob Ntiaj Teb **: suav nrog hauv Wada Banned Sau, ntau lub teb chaws nruj kev khiav ncig.

### ** 8. Cov ntsiab lus thiab Outlook **

FluoSxosterone tseem muaj txiaj ntsig zoo nyob hauv cov kev kho mob tshwj xeeb vim nws muaj zog Andrent AndraloToxicity, tab sis nws cov kev pheej hmoo hepatotoxicity thiab kev tsim txom cov kev pheej hmoo rau nws cov ntawv thov thoob plaws. Kev tshawb fawb yav tom ntej muaj xws li kev tsim cov txheej txheem sib piv tsawg dua thiab ua kom paub tau kev tsim txom tsis tau los ntawm kev ua phem. Nrog rau txoj kev txhim kho cov tshuaj kho mob, tej zaum nws yuav rov kho dua hauv kev kho cov tshuaj hormones.