Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

raws

product-1400-1400

Cov khoom lag luam

#### ** 1. Taw taw **

Anastrozole yog qhov ua tau zoo tsis yog-steroidal aromatase inhomant kev kho mob ntawm cov tshuaj hormone recepone mis. Raws li cov khoom siv thib peb-aromatase, nws tseem txo qhov kev pheej hmoo ntawm kev rov qab los ntawm kev tiv thaiv hluav taws xob estrogen rau kev kho mob cancer mis. Kab lus no yuav siv cov khoom siv tshuaj Aastroze los ntawm ntau qhov ntev, suav nrog cov tshuaj siv tshuaj, kev tswj tshuaj, kev tshuaj kho mob zoo, thiab cov kev pabcuam hauv khw.

#### ** 2. Tshuaj thiab Khoom Siv Lub Cev **

1. ** Cov ntaub ntawv yooj yim **

- ** "}}}}}}} {} {}} echlylpropiononitrile)

- ** tus lej lej **: 120511-73-1

- ** Molecular cov mis **: C17H19N5

- ** Molecular hnyav **: 293.36 g / mol

- ** Pom zoo ** ** Dawb rau off-dawb crystalline hmoov

- ** Solubility **: Yooj yim soluble hauv cov kuab tshuaj organic (xws li Methanol, DMOPS), me ntsis soluble hauv dej (<0.1 mg/mL).

2. ** Cov Qauv Hluav Taws Xob "

- Tus qauv tseem ceeb yog lub nplhaib triazole sib txuas nrog cov pab pawg benzene los ntawm cov pab pawg benzene, thiab cov pab pawg sib txuas, uas muab rau nws cov khoom siv aromatase.

- Cov qauv tsis yog menyuam roj ntsha tsis txhob muaj cov kev mob uas tsis muaj txiaj ntsig.

3. ** STABLY **

- ** Kev photosensity **: Yuav tsum tau muab cia kom deb ntawm lub teeb (2-8 degree} degree} degree} degree} degree} degree} degree} degree} degree refly).

- ** PHEM THIC KOM TIV THAIV **: Nyob ruaj khov nyob rau hauv acidic tej yam kev mob, yooj yim rau kev thuam hauv ib puag ncig alkaline.

#### ** 3. Pharmacological cuam tshuam thiab kev kuaj mob **

1. ** Mechanism ntawm Kev Ua **

- ** SCOMATIVE Inhibition **: Xaiv los khi rau Cytochrome P450 Arrostenione rau estrone estrogen qib (estrone hauv cov poj niam postmenopausal txo qis 80%).

- ** Heev me **: tsis muaj txiaj ntsig rau adrenal cortical cortical hormones synthesis, txo cov kev mob tshwm sim.

2. ** Kev kuaj xyuas cov txiaj ntsig **

- ** QHIA RAU TAMOXIFEN, 5-} Tus kab mob xyoo-} muaj sia nyob dawb los ntawm {%.

- ** Kev thev taus zoo **: Tsis muaj Estrogen agonist effect, txo txoj kev pheej hmoo ntawm endometrial cancer.

- ** Cov tshuaj kho kom yooj yim **: 1 mg ntawm ib hnub, ua raws siab ntev.

#### ** 4. Cov Txheej Txheem Ntau Lawm thiab Technology Ua Kom Txhim Kho **

1. ** Txoj kev Synthesis "

- ** Nruab nrab tseem ceeb **: 2, {5- pawg ntawm cov khoom siv uas pib, thiab tom qab ntawd,}}}} {}} triazole.

- ** Catalytic tus txheej txheem **: Palladium catalyst catalyst ruzuki coupling cov tshuaj tiv thaiv los ua kom zoo tshaj tawm (txog 75% lossis ntau dua).

2. ** Cov txheej txheem optimization **

- ** OB CARCHISION **: Cov kuab tshuaj dawb microwave synthesis yog siv los txo cov khib nyiab.

- ** PURIFICATION thev naus laus zis **: Cov kua dej chromatography (SFC) txhim kho Purity rau 99.9%.

#### ** 5. Tswjhwm thiab cov qauv **

1. ** Qhia qhov tseem ceeb rau cov cim taw qhia **

- ** Purity **: HPLC hom qauv txiav txim siab qhov tseem ceeb tshaj lossis sib npaug nrog 99.5%.

- ** EGGITURUR RIV tswj **: Paub impurities (xws li Decyano derivatives) tsawg dua lossis sib npaug {1}}. 15%.

- ** Microbial txwv **: Ntsib USP<61>Cov Qauv.

2. ** Cov kws ua haujlwm thoob ntiaj teb cov qauv "

- ** USP **: Cov ntsiab lus ya raws tsawg dua lossis sib npaug rau 0. 5%, kev nkag siab ntawm {{3%. 1%. 1%.

- ** EP **: Cov ntaub ntawv hlau hnyav tsawg dua los yog sib npaug rau 20 ppm.

#### ** 6. Cov ntaub ntawv raug mob thiab cov kev tswj xyuas sab?

1. ** Qhia tau **

- ** ** Tus mob cancer mis thaum ntxov **

- ** Metastatic mis cancer **: Thawj-kab endocrine kho.

2. ** Muab tshuaj thiab kho mob **

- ** Muab koob tshuaj 2 ** ** ** 1 mg ib hnub rau 5 xyoos.

- ** Cov pejxeem tshwj xeeb **: Cov neeg mob uas muaj lub siab tawv ua haujlwm yuav tsum tau txo cov tshuaj.

3. ** Kev phiv thiab cuam tshuam thiab

- ** Cov kev tawm tsam tshwm sim **: Kev mob sib koom tes (30%), kub flashes (20%).

- ** Qog tswj hwm mob pob txha **: Nws raug nquahu kom pab ntxiv calcium / vitamin D thiab saib xyuas pob txha ceev tsis tu ncua.

#### ** 7. Kev Ntsuam Xyuas Kev Lag Luam thiab Yav Tom Ntej Prospections **

1. ** Kev ua lag luam thoob ntiaj teb thawj zaug **

- ** Rau cov tuam ntxhab loj **: astrazeneca (thawj tshawb fawb), Tuam Tshoj HuaaHi cov chaw muag tshuaj, Is Nrias teb Cipli, thiab lwm yam.

- ** Daim Ntawv Muag Khoom Loj **

2. ** Kev Loj Hlob **

- ** Rau kev txhim kho cov ntaub ntawv ntau npaum li cas **: Kev txhaj tshuaj ntev thiab ua rau muaj kev ua kom ntev dua los txhim kho kom yooj yim.

- ** Kev kho kom haum **: ua ke nrog CDK4 / 6 inibitors (xws li palbociclib) los txhim kho kev ua tau zoo.

- ** Kev tshawb nrhiav qhov qhia tau tshiab **: Kev sim mob rau prostate cancer thiab endometriosis tsis tu ncua.

#### ** 8. Xaus **

Anastrozole tseem yuav ua rau daim teb ntawm endocrine kho kom mob cancer mis nrog nws cov kev ua haujlwm siab thiab kev nyab xeeb. Nrog kev tsim kho tshiab ntawm cov txheej txheem ntau lawm thiab kev nthuav dav ntawm nws cov ntaub ntawv nyoos yuav txuas ntxiv mus ntxiv, tsav tsheb ntawm kev ua lag luam thoob ntiaj teb.