Cov hmoov nplej anavar (oxandrolone) txhawb cov leeg loj hlob: 53-39-4

### Anavar (Oxandrolone) API hmoov Txheej Txheem Piav Qhia

Anavar (Oxandrolone) yog steroid anogolic (anabolic androgenic steroid, AAS). Txij li nws tau xub pib los ntawm cov tuam txhab Asmeskas cov tuam txhab searle (tam sim no pfizer) xyoo 1964, nws tau nyiam cov khoom lag luam uas tsis yog tshuaj xyuas thiab cov kev pheej hmoo ntawm cov kev mob tshwm sim. Kab lus no yuav ntsuas cov ncauj lus kom ntxaws ntawm Anavar cov khoom siv tshuaj, cov txheej txheem hluav taws xob, cov qauv ntawv thov thiab kev ua lag luam.

### 1. Tshuaj lom neeg thiab cov ntaub ntawv yooj yim

### 1. ** Cov Tshuaj Yooj Yim "

- ** LUB NPE LUB NPE **: Oxandrolone

- ** NTXIV NOJ **: Anavar (Hom nto moo tshaj plaws), Lonavar, Vasorome

- **} hydroxy {2}}}}}} {5 {5 5}}}}

- ** tus lej lej **: 53-39-4

- ** Molecular cov mis **: C₁₉h₃₀o₃

- ** Molecular hnyav **: 306.44 g / mol

- ** Tus yam ntxwv tsim qauv **:

Kev hloov kho qauv qauv raws li testosterone pob txha:

- Hloov chaw ntawm cov pa atom ntawm cov pa roj carbon thib ob (ua lub nplhaib lactone) → txhim kho kev ruaj khov;

- Methylation ntawm 17 txoj hauj lwm → Txo hepatic thawj-hla kev ua tiav thiab txhim kho qhov ncauj bioavailability;

{{0 {0}} Txo → Txo arerogen ua si.

### 2. ** Cov yam ntxwv lub cev **

- ** Pom zoo ** ** Cov hmoov dawb dawb lossis tawv-dawb, ntxhiab tsw ntxhiab lossis tus yam ntxwv tsw tsw txawv.

- ** Melting taw tes **: {{150-154 degree (high-purity APIS feem ntau yog ntau dua los yog sib npaug rau 152 degree).

- ** Solubility **:

- Me me soluble hauv dej (txog 0. 1 mg / ml, 25 degree);

- Yooj yim soluble hauv cov kuab tshuaj organic (xws li ethanol, chloroform, dmoform, dmo);

- Zoo dispersibility nyob rau lipid cov cab kuj, haum rau kev npaj ntawm qhov ncauj.

- ** STABLY **: Liaj-rhiab, yuav tsum tau muab cia kom deb ntawm lub teeb; Lub sijhawm ntev ruaj khov raws li cov xwm txheej qhuav (av noo tsawg dua los yog sib npaug rau 30%).

### 2. Pharmacological cuam tshuam thiab chaw kuaj mob zoo

#### 1. ** ** Cov kws tshuaj ntsuam me nyuam me me **

- ** ANABOLOLIC ASMS **:

Los ntawm kev khi rau androgen receptor (AR), nws ua kom cov gene cov ntawv sau, txhawb nqa cov khoom siv protein thiab cov leeg loj.

- ** anti-catabolic cov nyhom **:

Inhibits cov kev khi ntawm cortisol mus rau glucocorticoid receptors thiab txo cov leeg nqaij tawg.

- ** Qis androgenic kev ua si **:

Vim yog {5 - l} txo cov qauv, nws Androgenic kev ua si tsuas yog 1/6 ntawm testosterone, uas yog tsim nyog rau poj niam thiab tus menyuam dev.

### 2. ** Kev kuaj xyuas cov txiaj ntsig **

- ** Mob siab kev nyab xeeb **:

Tsis muaj C17 alkylation (tsuas yog 17 methyl), mob siab lom zem yog ho qis dua lwm cov tshuaj steroids (xws li stanzolol).

- ** Lipid Metabolism tus phooj ywg **:

Tsawg dua kev cuam tshuam rau cov lipoprotein (HDL), txo qis kev pheej hmoo plawv.

- ** Dav Dav Hlau Rau Cov Tub Ntxhais Tubres **:

Qhov tshwm sim ntawm masculinization phiv zoo (xws li sib sib zog nqus suab, hirsutism) tom qab siv hauv cov poj niam tsawg dua 5%.

- ** Qaum kev hloov pauv tau **:

The therapeutic window is wide, the common dosage range for adults is {{0}} mg/day, and children are adjusted by 0.1 mg/kg.

#### 3. ** Kev phiv thiab cov teeb meem "

- ** Cov kev mob tshwm sim ib txwm **:

- Kev nce me me hauv daim siab enzymes (reversible);

- dyslipidemia (yuav tsum saib HDL / LDL);

- Pob txuv, plaub hau (cuam tshuam rau tus kheej rhiab).

- ** Txaus ntshai heev **:

- Kev tsim txom ntev ntev yuav ua rau mob siab ntsws;

- Infibit prinogenous Testosterone zais (PCT pab txhawb).

- ** Cov pab pawg sib txhim kho tau **:

Cov neeg mob uas muaj mob prostate, mob cancer mis, thiab mob siab thiab mob raum tsis raug txwv.

### 3. Cov txheej txheem hluavtaws thiab cov API ntau lawm

### 1. ** OVERVIE ntawm Synthesis txoj kev **

Txoj kev lag luam synthesis ntawm Anavar feem ntau pib nrog ** Dehydroepiandrosterone (DHEA) ** LOSSIS ** mEROSSENDENSIONE **. Cov kauj ruam tseem ceeb suav nrog:

1. ** Epoxidation **: Qhia Oxygen Axs los ua lub nplhaib lactone;

2. 4. Methylation **: Tiv thaiv the {1}} methyl pab pawg kom txhim kho qhov ncauj ua ke;

3. ** Txo thiab Purification **: Tshem tawm ob npaug ntawm cov catalytic hydrogenation thiab purify los ntawm crystallization.

#### 2. ** Cov teeb meem sib tw **

- ** Kev tswj lub storeosectivity ** Nco ntsoov 5 - txo kev teeb tsa kom tsis txhob tsim ntawm 5 isomers (txo kev ua si);

- ** Kev tswj hwm tus kabmob ": seem ntawm cov nruab nrab (xws li epoxy derivatives) yuav tsum tau saib xyuas, thiab HPLC Purity yuav tsum muaj ntau dua los yog sib npaug rau 99.5%;

- ** Qog Ntsuab Nees Ua Kom Zoo Dua **: Txo cov kev siv cov hlau hlau hnyav (xws li palladium) thiab siv biocatalysis) thiab siv biocatalysis) thiab siv biocatalysis) thiab siv biocatalysis) thiab siv biocativyyiv hnyav.

#### 3. ** Qhov API cov lus qhia tawm **

- ** Purity txheem **:

- Lub ntsiab tivthaiv ntau dua los yog sib npaug rau 99. 0% txiav txim los ntawm HPLC;

- Ib qho impurity tsawg dua los yog sib npaug rau 0. 5%, Tag nrho cov impurities tsawg dua los yog sib npaug rau 1. {}}%.

- ** Residual Hnyav **:

Ntsib Ich Q3C Cov Lus Qhia, Methanol<3000 ppm, ether <500 ppm.

- ** TSIB NCAB TSEEB **:

Yuav tsum ua kom tau raws li qhov yuav tsum muaj ntawm cov api sterilization lossis cov asteptic yuav tsum tau).

### 4. Daim ntawv thov cov chaw thiab kev tsim kho qauv

#### 1. ** Kev kho mob **

- ** Hlob Kev Rov Kho Kom Rov Kawm **:

Txhawb cov protein synthesis thiab luv dua lub tsev kho mob nyob (FDA pom zoo qhia tau).

- ** HIV-errel ntsig wasting syndrome **:

Ua kom muaj lub cev nqaij ntshiv huab cua thiab txhim kho lub neej zoo (cov chaw kuaj mob txaus).

- ** Osteoporosis **:

Pab rau hauv cov pob txha ua kom nruj, tshwj xeeb tshaj yog rau cov pob txha glucocorticoid-ua rau pob txha glucocorticoid-induced.

- ** Rau cov menyuam txoj kev cuam tshuam loj zuj zus **:

Siv rau Turner Syndrome thiab Chonic Malnutrition (nruj Dosage soj ntsuam yog yuav tsum tau).

### 2. ** Cov ntaub ntawv tsis yog tshuaj khomob (cov chaw muaj kev sib cav sib ceg) **

- ** Kev tw kis las **:

Sau raws li kev txwv los ntawm Wada, tab sis vim yog lub qhov rai luv luv (3-4 lub lis piam), muaj kev tsim txom.

- ** QAUV thiab cov leeg nqaij **:

Vim nws cov dej dej qis thiab cov dej sodium khaws cia, nws yog tus muaj txiaj ntsig los ntawm kev siv lub cev, tab sis kev pheej hmoo ntawm kev siv tsis raug cai yog siab.

#### 3. ** Daim ntawv npaj **

- ** Cov ntsiav tshuaj ntawm qhov ncauj **: 2.5 mg, 10 mg cov lus qhia tshwj xeeb, feem ntau siv cov kev paub tau muaj xws li cov lactose thiab magnesium stearate;

- ** Customized capsules **: Ntau yam nyob rau hauv kev ua lag luam grey, nrog kev pheej hmoo siab ntawm cov khoom lag luam ntau npaum li cas;

- ** Supermal Gel **: Qhov kev sim tshuaj uas tuaj yeem txo cov txheej txheem thawj zaug dhau ntawm daim siab.

### 5. Cov qauv zoo thiab kev tswj hwm

#### 1. ** Thoob ntiaj teb Pharmacopoeia cov qauv **

- ** USP-NF **:

Qhia tshwj xeeb infrared spectroscopy (ir) thiab tlc rau kev txheeb xyuas, thiab ultraviolet spectrophotometry rau cov ntsiab lus kev txiav txim siab.

- ** EP **:

Yuav tsum tshuaj xyuas cov tshuaj tsis zoo (HPLC-UV txoj kev), cov hlau hnyav tsawg dua los yog sib npaug rau 20 ppm.

- ** JP **:

Kev ntsuas kev ntsuas (30- feeb tso ntau dua lossis sib npaug rau 80%).

#### 2. ** GMP ua raws li **

- API cov khoom siv yuav tsum nrog FDA / EMA GMP cov qauv, suav nrog:

- Peb-theem Cua Fotration System (ISO 8 lub cheeb tsam huv);

- Cov txheej txheem tag nrho cov txheej txheem traceazility;

- Kuaj ruaj khov (nrawm 6 lub hlis, sijhawm ntev 24 hli.

#### 3. ** Ntshuam thiab xa tawm tswj **

- ** Tebchaws Asmeskas **: DEA DEA npe nws ua lub sijhawm III tswj cov khoom;

- ** CHANIAN **: nruj me ntsis tswj hwm raws li cov cai ntawm kev tswj hwm ntawm cov tshuaj narcotic thiab yeeb tshuaj yeeb tshuaj;

- ** EU **: Daim ntawv tso cai ntshuam tshwj xeeb yog yuav tsum tau (xws li Ltalis DM 11/2011).

### 6. Kev Lag Luam Kev Lag Luam thiab Cov Chaw Tsim Tshuaj Ntsuam Xyuas

### 1. ** Cov pob hluav taws xob hauv ntiaj teb **

- ** Daim duab yeeb tshuaj **: Pfizer tuav thawj daim duab patent, tab sis nws tau tas sij hawm hauv ntau lub teb chaws;

- ** TSEEB AP API ntau lawm cov teb chaws ntau dua **:

- ** Is Nrias teb **: Xws li Sympiosis Labs thiab Zaj Duab, nrog tus nqi qis tab sis tsis sib xws;

- ** Suav teb **: Ntau lub tuam txhab hauv Hubei thiab Jiangsu tau dhau FDA ntawm kev soj ntsuam thiab muab cov ntaub ntawv raw ntau;

- ** Tebchaws Europe **: Qee cov tuam txhab Italian tsom rau GMP-qib raw cov ntaub ntawv, uas yog kim.

### 2. ** Ntxawm tus nqi **

- ** Tus nqi ntawm API **:

- Muaj Qib Muaj Qib Muaj Zog (95% Purity): $ 2, {3}}}}, 500 / kg;

- Pharmacopoeia grade ( Greater than or equal to 99%): $8,000-12,000/kg;

- Kev cai synthesis (GMP qauv): ntau dua los yog sib npaug rau $ 15, 000 / kg.

- ** Caw cov ntsiab lus **:

Hloov pauv hauv cov nqi ntawm cov ntaub ntawv raw (xws li DHEA), cov kev cai ib puag ncig ib puag ncig, thiab sawv ntawm cryptocurrency them.

#### 3. ** TITING PROMIT **

- ** Nug cov ntsiab lus kev loj hlob **:

Kev nthuav dav ntawm kev kho mob ntawm cov teb chaws tawm, tawm-daim ntawv lo rau hauv kev tiv thaiv kev laus;

- ** Cov nyom **:

Lub teb chaws muaj zog steroid txoj cai thiab kev sib tw los ntawm biosimilars (xws li xaiv Androgen cov andCen receptor modulators).

### xaus

Anavar API tseem mus ua si lub luag haujlwm hauv cov qauv kev kho mob tshwj xeeb vim nws cov teeb meem kev noj qab haus huv thiab kev noj qab haus huv los ntawm nws tsis quav ntsej. Yav tom ntej, nrog kev nce qib ntawm cov tshuaj thev naus laus zis thiab nws yog qhov tsim kho tshiab ntxiv, tab sis nws yog qhov tsim kho tshiab thiab kev nyab xeeb raws txoj cai tswj hwm lub moj khaum.

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Cim npe nrov: Cov hmoov nplej anavar (oxandrolone) txhawb cov leeg kev loj hlob Cas: {} {{{{{53-39-4 Cov chaw tsim khoom, cov chaw tsim khoom, Hoobkas