Taw qhia

Siab -Purity AAS Raw Powder Factory Qhuav Thiab Kev Thauj Khoom

Txhim kho cov leeg nqaij thaum lub sij hawm kev cob qhia

High -Purity Aas Raw Materials

Kev thauj mus los thoob ntiaj teb

Factory Mass Production

Mechanism ntawm Action

Eu Region Express Tsheb thauj mus los

Khoom Description

## 1. Tshuaj Formula

C₂₂H₁₉N₃O₄

## 2. CAS Nr

**171596-29-5**

## 3. Molecular Luj

389.40 g / mol **

## 4. Cov tsos mob thiab lub cev muaj zog

- Pom: ** Dawb los yog tawm - dawb crystalline hmoov **

- Tsis hnov tsw: tsw, tsw tsw

- Melting Point: Kwv yees **298-302℃**

- Solubility: Yuav luag **insoluble hauv dej**; me ntsis soluble hauv methanol thiab ethanol; Yooj yim soluble hauv cov kuab tshuaj organic xws li dichloromethane thiab DMF

- Kev ruaj ntseg: **Chemically ruaj khov** nyob rau hauv ib txwm kub, lub teeb- tiv thaiv, kaw, thiab qhuav tej yam kev mob

- Khoom: hmoov zoo, siab purity, tsis muaj pob; rhiab heev rau cov av noo, yuav tsum tau ya raws - pov thawj thiab kaw cia

Lub ntsiab kom zoo dua ntawm siab - zoo tadalafil raw cov ntaub ntawv yog nyob rau hauv cov txheej txheem nruj tswj thiab nrhiav qhov kawg purity. Tsis zoo li cov khoom siv raw zoo tib yam uas tsuas yog ua tau raws li tus qauv yam tsawg kawg nkaus ntawm cov tshuaj pharmacopoeia, siab - cov ntaub ntawv raw zoo siv cov khoom siv chiral siab heev thiab cov txheej txheem txuas ntxiv mus. Pib nrog tryptamine, tsib - cov kauj ruam meej cov tshuaj tiv thaiv yog siv los tsim cov pyrazine-indole core ring system. Los ntawm asymmetric catalysis thev naus laus zis, stereoselectivity ntawm chiral intermediates yog xyuas kom muaj ntau dua lossis sib npaug rau 99.5%, thiab qhov kawg HPLC purity yog ntau dua lossis sib npaug rau 99.8%, nrog rau ib qho impurity Tsawg dua lossis sib npaug li 0.1% thiab tag nrho cov impurities tswj qis dua 0.5%, uas yuav tsum tau nyob deb ntawm tag nrho cov qauv.

Qhov purity qhov kawg no tuaj yeem tsis tsuas yog ua kom muaj txiaj ntsig zoo xwb, tab sis kuj txo cov kev pheej hmoo ntawm kev ua xua, lub siab thiab lub raum lub nra los ntawm impurities, thiab muab kev ruaj ntseg lav rau ntev - siv tsis tu ncua. Ntev -lub sij hawm yooj yim thiab siab compatibility yog lwm qhov tseem ceeb ntawm cov khoom zoo -tadalafil raw khoom. Nws cov qauv molecular tshwj xeeb muab rau nws ib nrab -lub neej txog li 36 teev. Piv nrog cov ntaub ntawv raw zoo sib xws, tsis tas yuav tsum nruj tswj lub sijhawm sib txawv ntawm kev siv tshuaj thiab kev sib deev, uas ua rau txo qis kev puas siab puas ntsws rau cov neeg mob thiab paub txog cov kev hloov pauv ntawm "kev xav tau tshuaj". Dab tsi yog qhov tseem ceeb tshaj yog qhov siab - cov khoom siv raw zoo tsis cuam tshuam los ntawm kev noj haus. Txawm hais tias nws yog ib qho khoom noj muaj roj ntau lossis haus cawv me me, lawv qhov kev nqus tau zoo tsis cuam tshuam. Tsis tas li ntawd, tom qab siv lead ua daim ntawv optimization, tus nqi tawg tuaj yeem ncav cuag 97% hauv 30 feeb, txhim kho bioavailability thiab hloov mus rau qhov kev xav tau ntawm lub cev sib txawv.

Qhov kev ua txhaum ob zaug hauv kev ruaj ntseg thiab kev nyab xeeb ua rau siab -cov khoom siv tadalafil zoo sawv tawm. High- cov ntaub ntawv zoo raw khoom yog taw qhia rau hauv hom I superior tshuaj siv lead ua cov ntaub ntawv los ntawm cov kuab tshuaj gradient crystallization thiab kub tswj, nrog crystal form purity ntau dua los yog sib npaug rau 99%. Nyob rau hauv ib txwm cia tej yam kev mob, lawv tsis yooj yim degraded, zoo dua lub txee lub neej ntawm formulation. Nyob rau tib lub sijhawm, kev tswj hwm impurity nruj me ntsis raws li ICH Q3C cov lus qhia, thiab cov ntsiab lus ntawm cov kuab tshuaj seem thiab cov hlau hnyav ua tau raws li cov qauv thoob ntiaj teb. Piv nrog rau cov khoom siv raw zoo tib yam, qhov no txo qis qhov tshwm sim ntawm qhov tshwm sim tsis zoo xws li mob taub hau thiab myalgia. Txawm tias cov neeg mob uas muaj kab mob hauv qab xws li kub siab thiab ntshav qab zib tuaj yeem siv nws yam xyuam xim raws li kev cob qhia kws tshaj lij.

Niaj hnub no, siab -cov ntaub ntawv zoo tadalafil raw khoom tsis yog "cov khoom xyaw tshuaj," tab sis tau dhau los ua qhov kev sib tw tseem ceeb rau cov tuam txhab tshuaj hauv kev tsim cov khoom siab tshaj - kawg. Nws rhuav tshem qhov kev txiav txim siab tias "cov khoom siv raw hauv tsev=tsis zoo". Qee qhov siab -cov ntaub ntawv raw khoom zoo hauv tsev tau raug kho dua tshiab los ntawm kev siv thev naus laus zis, thiab lawv cov purity thiab ruaj khov tau mus txog lossis txawm mus txog qib siab thoob ntiaj teb. Qhov no muab kev txhawb zog rau lub zos thiab cov qauv ntawm cov tshuaj andrology. Raws li cov khoom siv tseem ceeb hauv kev kho mob andrology, siab -tadalafil zoo yog nyob ntawm cov txheej txheem thiab purity. Nws rov txhais cov kev paub tshuaj nrog nws cov kev ua tau zoo thiab ua rau muaj kev nyab xeeb dua, yooj yim dua thiab muaj txiaj ntsig kev kho mob rau cov neeg mob ntau dua.