Xov xwm Cov ntsiab lus
LL37's antiviral peev xwm yog qhov tshwj xeeb tshaj yog. Cov pab pawg tshawb fawb coj los ntawm Zhang Conggang ntawm Tsinghua University tau tshawb pom tias nws tuaj yeem ua lub luag haujlwm ua haujlwm tau zoo ntawm "tus neeg xa xov xwm tiv thaiv kab mob" cGAMP, ob txoj kev xa cov kab mob tiv thaiv kab mob thoob plaws daim nyias nyias, ua kom muaj zog STING txoj hauv kev thiab interferon- kho cov tshuaj tiv thaiv kab mob, thiab yuav luag tag nrho cell eliminating. Qhov kev tshawb pom no tseem nthuav tawm cov lus tsis meej ntawm cov vitamin D cov tshuaj tiv thaiv kab mob - nws siv nws cov teebmeem los ntawm kev ua rau LL37 qhia. Cov kev tshawb fawb soj ntsuam kuj tau lees paub tias kev tswj hwm qhov ncauj ntawm LL37 muaj qhov cuam tshuam tseem ceeb ntawm Omeprone variant.https://www.fiercerawsource.com/peptides/premium-high-purity-peptides-ll37.html
Hauv kev kho mob antitumor, kev tshawb fawb los ntawm pab pawg Charles Sturt University qhia tau hais tias LL37 tuaj yeem koom nrog tag nrho cov txheej txheem ntawm kev npaj hauv vitro dendritic cell, ua kom cov qog ua kom zoo dua qub - tua cov kev ua ntawm CD8+ T hlwb, thaum txo qis PD-1 qhia thiab txhim kho kev ua haujlwm ntawm kev tiv thaiv kab mob. Tam sim no, cov thev naus laus zis ntsig txog tau dhau los ua cov cuab yeej tshiab rau kev kho mob qog noj ntshav cell immunotherapy.
Kev kho cov ntaub so ntswg thiab kev tiv thaiv lub cev yog lwm qhov tseem ceeb ntawm LL37. Kev tshawb fawb ntawm Yantai Yuhuangding Tsev Kho Mob qhia tau hais tias nws txhawb nqa angiogenesis los ntawm VEGFA-PI3K / AKT / mTOR txoj hauv kev, txhim kho cov tsos mob ntawm qis qis ischemia. Cov kev sim tshuaj kho mob tau lees paub tias daim ntawv thov tshuaj pleev xim ntawm LL37 tuaj yeem txo qhov chaw ntawm refractory venous ulcers los ntawm 68%, thaum LL37 formulations encapsulated nyob rau hauv keratin hydrogel tuaj yeem ua kom tag nrho - tuab qhov txhab kho. Tsis tas li ntawd, nws muaj peev xwm inhibit alveolar epithelial cell pyroptosis, txhim kho septic ntsws raug mob, thiab tiv thaiv lub plab hnyuv muaj nuj nqi nyob rau hauv cov neeg mob nrog heatstroke.
Los ntawm kev tiv thaiv kab mob tiv thaiv kab mob rau lub hom phiaj kho mob, ntau yam txiaj ntsig ntawm LL37 tab tom tshawb nrhiav tsis tu ncua. Nrog rau kev ua kom zoo tshaj plaws ntawm kev xa khoom, nws cov kev siv tshuaj kho mob hauv cov kab mob sib kis, qog, thiab cov qhov txhab mob ntev yuav tsum nthuav dav ntxiv.
