Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

peptides

product-1400-1400

Cov khoom lag luam

#### 1. OvertView

** BPC -157}} ** (Lub cev tiv thaiv cov compound {1}}} Txij li thaum nws tshawb pom ntawm xyoo 1990, nws tau maj mam dhau los ua lub ntsiab lus kub hauv kev tshawb fawb txog kev kho mob vim nws cov khoom ntiag kho thiab tiv thaiv cov khoom. Cov polypepride no yog paub txog nws cov kev ua haujlwm dav dav, tiv thaiv kev ua kom dav, tshuaj tiv thaiv, tshuaj lom neeg tshuaj thiab cov kev cai tswj tshuaj thiab redenerative tshuaj.

### 2. Cov qauv tshuaj thiab lub cev thiab tshuaj lom neeg

** 1. Tshuaj lom neeg sib xyaw ua ke **

- ** Cov mis molecular **: C₆₂h₉₈n₁₆o₂₂

- ** Molecular hnyav **: 1419.5 da

- ** Amino acid sequence **: Gly-Glu-Pro-Gly-Lys-as-ly-as-as-as-as-as-as-as-as-as-as-as-as-as-idginal

** 2. Lub cev lub cev **

- ** Pom zoo **: feem ntau yog dawb lossis off-dawb crystalline hmoov, homogeneous thiab xoob lub xeev thaum muaj ntau dua los yog sib npaug rau 98%.

- ** Solubility **: Yooj yim soluble hauv dej ({1}}} mg, 25 degree), insoluble hauv tsis-polar cov kuab tshuaj.

- ** STABLY **: ruaj khov nyob rau hauv cov phote ntawm 3-8, yooj yim rau kev kub siab (> 60 degree) lossis muaj zog acid / alkali ib puag ncig. Lub Xeev khov-qhuav tuaj yeem khaws cia rau ntau tshaj 2 xyoos ntawm -20 degree.

** 3. Qhov khoom kho qhov muag **

- Tsis muaj qhov tseem ceeb UV nqus lub ncov siab, cov kev tshawb xyuas cov pa hluav taws xob ntawm HPLC lossis loj spectrometry.

#### 3. Cov khoom siv pharapacological thiab molecular txheej txheem

** 1. Cov nqaij mos kho thiab kho dua tshiab **

- ** TXHAWJ KUB AVIOGENESIS **: Ua kom nrawm nrawm nrawm nrawm ntawm cov ntaub so ntswg uas puas tsuaj los ntawm kev ua siab rau vegf thiab fgf2 qhia.

- ** Collagen synthesis **: Qhib tgf- pathway, txhim kho fibroblast proliferation thiab extracellular matrix.

** 2. Anti-inflammatory thiab tshuaj tiv thaiv kab mob **

- inhibit pro-inflammatory yam xws li tnf- thiab -6}}}}, thiab -10).

- tswj nitric oxide (tsis muaj) txoj kev thiab txo cov oxidative kev puas tsuaj.

** 3. Neuroproction **

- Txhawb kev muaj zog synaptic thiab txhim kho kev ua haujlwm rov qab tom qab central thiab qhov kev raug mob sab nrauv.

** 4. Kev tiv thaiv lub plab zom movation **

- Txhim kho cov plab zom mov txo, nrawm rau kev kho mob rwj

#### 4. Daim ntawv thov cheeb tsam thiab chaw kuajmov muaj peev xwm

** 1. Cov Kab Mob Uas Digestive **

- ** POJ NOJ thiab Enditttric Ulccer thiab Enteritis **: Hauv cov qauv tsiaj, BPC {1}} tuaj yeem txo lub sijhawm kho mob los ntawm 50%, uas yog qhov zoo dua li omePrazole.

- ** Daim siab puas kho **: Txo CCL 4- Ua rau lub siab fibrososis thiab txo qib alt / ast.

** 2. Cov tshuaj kis las thiab orthopedics **

- ** Tendon thiab Ligament Kho Vaj Tsev **: Kev Tshawb Fawb Kev Tshawb Fawb Qhia tias kev txhaj tshuaj hauv zos tuaj yeem txo lub sijhawm ua kis las nrog kev ua kis las.

- ** Severure Kho **: Tshawb nrhiav nrawm los ntawm kev ua kom lub BMP txoj kev.

** 3. Cov Kab Mob Neurological **

- ** Kev raug mob txha caj qaum ** Hauv cov qauv nas, BPC -157}} promotes lub cev muaj zog ua haujlwm rov qab thiab txo cov good nti.

- ** Parkinson tus kab mob **: Muaj peev xwm dopaminergic neuroprotefive cuam tshuam, tseem nyob rau hauv cov kev tshawb fawb preclinical theem.

** 4. Daim tawv nqaij thiab hlawv kho **

- Ua kom muaj kev cuam tshuam Epidermal (EGF), nrawm nruam paug epithelialization, thiab txo kev caws pliav tsim.

#### 5. Npaj thiab tswj hwm txoj kev

** 1. Qhov ncauj npaj **

- Txawm hais tias peptides feem ntau muaj qhov ncauj tsis muaj zog (<5%), BPC-157 has significant local effects in the gastrointestinal tract, and enteric-coated capsules or sustained-release tablets are commonly used.

** 2. Kev txhaj tshuaj tshuaj txhaj **

- ** SUBCEDANE / INSTAMUSTCULARY Kev txhaj **: Bioavailability yog 70% {2}}}}}}}}}.

- ** Kev txhaj tshuaj tiv thaiv hauv zos **: ncaj qha rau kev ua txhaum kev raug mob lossis caj dab, nrog kev xav ntawm {1}} mg / ml.

** 3. Topical npaj **

- Nyob rau hauv daim ntawv ntawm gel lossis cream, siv rau cov tawv nqaij mob lossis hlawv, qhov nkag mus ua tau zoo yog nyob ntawm Nanocarrier Technology.

#### 6. Kev nyab xeeb thiab toxicology

- ** Soj thooj Toxicity **: RAT LD₅₀ ** 500 mg / kg (ntau dua tshaj qhov tshuaj kho), tsis muaj Teratogenicity lossis Genotoxicity tau pom.

- ** Kev siv ntev ntev **: Tsis muaj cov kev hloov pauv hauv lub caij pathological tau pom nyob rau hauv {2}}} Kev sim ua ntej, qhia txog kev ua siab ntev.

- ** Cov kev mob tshwm sim **: Cov ntawv qhia hauv tsev kho mob tsis tshua muaj, qee zaus liab thiab o ntawm qhov chaw txhaj tshuaj, tsis muaj kev cuam tshuam zoo.

#### 7. Kev tshawb fawb txwv thiab cov lus qhia yav tom ntej

- ** Cov ntaub ntawv tsis txaus yog cov ntaub ntawv tsis txaus **: lub neej ib nrab ntawm lub neej thiab cov pidpicolic hauv tib neeg lub cev tseem tsis tau meej.

- ** Cov nyom rau cov khoom lag luam loj loj dua **: Txoj kev sibtsy synthesis yog tus nqi tsim nyog thiab cov kev hais tawm tau zoo yuav tsum tau tsim.

- ** Lub peev xwm rau kev sib txuas nrog kev sib xyaw ua ke **: ua ke nrog kev loj hlob muaj los yog qia cell kev kho mob, nws tuaj yeem txhim kho cov txiaj ntsig zoo.

#### 8. Xaus

BPC -157}} Tau ua ib lub hnub qub molecule hauv thaj teb cov tshuaj kho dua tshiab vim nws lub hom phiaj kho ntau hom, muaj peev xwm tsawg thiab dav dav. Nrog rau kev ua kom zoo ntawm kev xa khoom thev naus laus zis thiab kev nce qib ntawm theem i i i i i i i i i irmerategents kab mob thiab cov kab mob sib koom ua ke yog qhov tsim nyog saib rau pem hauv ntej. Yav tom ntej, nws cov molecular network thiab cov khoom siv kho mob txhais lus yuav tsum tau tshawb fawb ntxiv los txhawb kev kho mob.