Cov ntsiab lus kev paub
Hauv kev lag luam ntawm txiv neej kev noj qab haus huv thiab oncology, nws yog "pob zeb tshuaj" rau kev kho mob qog noj ntshav prostate. Prostate cancer hlwb nyob ntawm androgens rau kev loj hlob. Triptorelin pib thiab ua haujlwm tsis tu ncua ua rau GnRH receptors, txhawb kev tso tawm ntawm luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH) (ignition effect). Txawm li cas los xij, kev siv tas mus li (xws li ntev - kev ua yeeb yam ntawm 3.75 mg txhua 28 hnub) ua rau receptor desensitization, ua rau poob qis dua 90% hauv LH thiab FSH secretion, thiab qib testosterone mus rau "castration state" (<50 ng/dL), thereby inhibiting cancer cell proliferation. Compared to surgical castration, it avoids trauma, and HPG axis function can recover within 3-6 months after discontinuation, making it suitable for young patients who wish to preserve fertility.https://www.fiercerawsource.com/peptides/premium-high-purity-peptides-triptorelin-gnrh.html
Hauv kev ua haujlwm ntawm poj niam kev noj qab haus huv, nws ua tiav "bidirectional precise regulation": ua ntej, hauv kev kho mob ntawm endometriosis thiab uterine fibroids, los ntawm inhibiting estrogen secretion (estradiol poob mus rau menopausal), nws ua rau ectopic lesions ntsws, fibroids txo qhov loj ntawm 30% {{4}. dysmenorrhea nyem cov nqi siab tshaj 80%, thiab tuaj yeem siv ua ntej los txo cov ntshav los ntshav; Qhov thib ob, nws yog lub hauv paus ntawm "downregulation" hauv kev pabcuam kev ua menyuam yaus (ART), thiab nws siv rau 14 hnub ua ntej ovulation induction tuaj yeem cuam tshuam LH surges thaum ntxov, tiv thaiv kev loj hlob ntawm cov follicle ntxov ntxov, synchronize txoj kev loj hlob ntawm ntau cov follicles, thiab nce cov qe qe zoo los ntawm 20% -30%.
Hauv kev kho menyuam yaus, nws yog thawj - kab kev kho mob rau lub hauv paus precocious puberty (CPP). Cov menyuam yaus uas muaj mob qog nqaij hlav prostate (CPP) tau dhau los ua neeg laus thaum ntxov vim qhov ua kom ntxov ntawm HPG axis. Triptorelin tuaj yeem cuam tshuam GnRH teeb liab thiab ncua lub hnub nyoog ntawm cov pob txha kaw- cov ntaub ntawv kho mob qhia tau hais tias tom qab siv tshuaj, tus nqi ntawm cov pob txha muaj hnub nyoog qis dua 1.5 xyoo hauv ib xyoos mus rau tsawg dua 0.5 xyoo hauv ib xyoos, ua rau nce 5-10 cm hauv qhov siab kawg ntawm cov neeg laus, tsis muaj kev cuam tshuam rau kev loj hlob mus ntev.
Nco ntsoov qhov kev pheej hmoo ntawm "kev cuam tshuam hluav taws xob": Thaum thawj zaug 1-2 lub lis piam ntawm kev siv tshuaj, kev nce ib ntus ntawm cov tshuaj hormones tuaj yeem ua rau mob pob txha (hauv cov neeg mob qog nqaij hlav cancer) lossis los ntshav ntawm qhov chaw mos (hauv cov poj niam cov neeg mob), yuav tsum tau siv cov tshuaj tiv thaiv -androgens lossis estrogen receptor antagonists rau kev pab. Kev siv mus ntev yuav tsum tau saib xyuas cov pob txha pob txha pob txha thiab, yog tias tsim nyog, ntxiv calcium ntxiv. Qhov tseem ceeb, tus nqi ntawm triptorelin nyob rau hauv nws "kev tswj hwm kev tswj hwm ntawm endocrine axis," ua kom muaj txiaj ntsig zoo tshaj plaws los ntawm kev siv tshuaj kho tus kheej.
