Cov ntsiab lus kev paub
### 1. Qib Biochemical:
https://www.fiercerawsource.com/peptides/premium-siab-purity-peptides-sermorelin-2mg.html
Pib hauv 2-4 teev, mus txog basal homeostasis hauv 1-2 lub lis piam. Sermorelin muaj qhov ncauj bioavailability tsawg heev; Hauv cov chaw kho mob thiab kev tawm dag zog, feem ntau yog siv los ntawm kev txhaj tshuaj subcutaneous (0.2-0.5 mg txhua hnub, zoo txhaj tshuaj 30 feeb ua ntej yuav mus pw). Pulsating GH secretion los ntawm lub caj pas pituitary tshwm sim 2-4 teev tom qab txhaj tshuaj, nrog rau cov ntshav siab GH concentration (3-5 zaug siab dua li qhov hauv paus). Txawm li cas los xij, lub sijhawm luv luv no tsis yog qhov taw qhia tseem ceeb ntawm "kev pib ua haujlwm" - qhov tseeb ntawm biochemical kev ua tau zoo nyob hauv kev tsim cov homeostasis tom qab kev txhawb nqa.
Tom qab 1-2 lub lis piam ntawm kev siv tas mus li, theem ntawm insulin-zoo li kev loj hlob zoo tshaj plaws-1 (IGF-1) synthesized los ntawm lub siab yuav nce ntxiv (qhov nruab nrab nce ntawm 20%-30%), uas yog ib qho tseem ceeb qhia txog seb nws puas tau qhib lub endocrine axis. Raws li tus neeg sawv cev tseem ceeb ntawm GH kev ua, qhov ruaj khov nce hauv IGF-1 concentration qhia tau hais tias lub cev tau nkag mus rau hauv lub xeev ntawm "sustained endogenous GH secretion," tso lub hauv paus rau kev txhim kho tom ntej ntawm lub cev. Txawm hais tias tsis muaj qhov pom tseeb ntawm lub cev thaum lub sijhawm no, kev kuaj ntshav tuaj yeem paub meej tias lub teeb liab ntawm kev ua tau zoo, nws txawv ntawm qhov hloov pauv, nce nrawm hauv IGF-1 tom qab exogenous GH txhaj.
### 2. Kev xav ntawm lub cev:
Kev Ceeb Toom Ua Ntej Tshaj Li 3-8 lub lis piam, tsom mus rau "Rov qab thiab Txhim Kho Cov Txheej Txheem"
Sermorelin cov teebmeem yog qhov pom tau zoo tshaj plaws nyob rau hauv 3-8 lub lis piam, tus cwj pwm los ntawm "kev txhim kho tsis zoo," ua raws li nws cov txiaj ntsig tseem ceeb ntawm "kev cai maj mam":
- 3-4 Lub Limtiam: Pw tsaug zog zoo ua ntej, pom tau tias yog lub sijhawm pw tsaug zog luv dua, lub sijhawm pw tsaug zog ntev dua (kev soj ntsuam xyuas pom tau tias 15% -} 20% nce hauv feem pua pw tsaug zog), txo qhov qaug zog thaum sawv ntxov, thiab kev txhim kho thaum nruab hnub - qhov no yog vim GH feem ntau zais thaum hmo ntuj, thiab Sermorelin txhawb lub cev kev ua haujlwm ntawm lub cev.
- 6-8 Lub lis piam: Kev hloov pauv tshwm sim hauv cov roj metabolism thiab cov leeg mob. Cov rog plab plab maj mam txo qis (qhov nruab nrab ntawm cov rog hauv lub cev txo qis ntawm 1.5%-2.5%), cov leeg txhais tau ua firmer (tsis yog los ntawm cov leeg nqaij loj hlob sai, tab sis los ntawm kev txo qis cov rog hauv cov leeg), thiab tom qab ua haujlwm cov leeg nqaij mob rov qab tau luv los ntawm kwv yees li 30%, ua tsaug rau kev ua kom muaj zog ntawm cov leeg nqaij .
Qhov sib txawv ntawm qhov pib tshwm sim ntawm theem no yog qhov tseem ceeb: cov neeg hluas lossis cov neeg uas tsis muaj zog pituitary ua tsis taus pa yuav ua rau pom kev txhim kho thaum ntxov li 2-3 lub lis piam; Txawm li cas los xij, cov neeg muaj hnub nyoog tshaj 40 xyoo, cov uas nquag nyob lig, lossis cov neeg muaj kev ntxhov siab siab yuav xav tau 4-6 lub lis piam kom pom kev txhim kho tseem ceeb vim qhov qis pituitary rhiab heev.
### 3. Ntev-Lub Sij Hawm Sib Sib Zog:
Tshaj li 12 lub lis piam, Kev ua kom zoo ntxiv ntawm Metabolic thiab Kev Laus Qhov Ntsuas Tom qab 12 lub lis piam ntawm kev siv tas li, Sermorelin cov teebmeem nkag mus rau theem tob, txuas ntxiv kev txhim kho los ntawm kev hnov ntxhiab tsw rau cov cim physiological tseem ceeb:
- Qib metabolic: Basal metabolic tus nqi nce 10%-15%, tswj qhov hnyav txawm tias tsis muaj kev noj qab haus huv kev noj qab haus huv, thaum tswj cov ntshav qab zib kom zoo (insulin rhiab heev los ntawm 25%), qhov tshwm sim ntawm IGF-1 txhawb nqa cov piam thaj hauv lub cev.
- Los tiv thaiv- Kev laus thiab Kho Qib: Txhim kho daim tawv nqaij elasticity, txo cov kab zoo, thiab cov pob txha ceev (tshwj xeeb tshaj yog nyob rau hauv lub lumbar qaum thiab lub duav) nce 3%-5% piv rau cov hauv paus, haum rau kev kho qhov sib koom ua ke thiab tsim kua muag tshwm sim los ntawm kev siv sij hawm ntev - kev cob qhia - cov kev cuam tshuam tsis tu ncua ntawm fibroblasts thiab osteoblasts los ntawm IGF-1, "kev kho tob" uas lub sij hawm luv luv exogenous GH ua tsis tau. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov ceev ntawm nws cov nyhuv kuj cuam tshuam los ntawm txoj kev siv: kev txhaj tshuaj thaum lub sij hawm pw tsaug zog (ua ke nrog lub cev tsis muaj zog ntawm GH) siv 1-2 lub lis piam sai dua li kev txhaj tshuaj ntawm lub sijhawm random; Kev sib xyaw ua ke nrog cov khoom noj muaj protein ntau (1.8-2.2g protein ib kilogram ntawm lub cev hnyav) tuaj yeem txhim kho IGF-1 synthesis efficiency, tso cai rau kev txhim kho sai sai.
Zuag qhia tag nrho, Sermorelin cov txheej txheem tseem ceeb ntawm kev ua haujlwm yog "ua kom tsaug zog ntau dua li hloov." Nws tsis muaj peev xwm tam sim ntawd ntawm exogenous GH, tab sis ua tau zoo nyob rau hauv nws maj mam thiab ntev - cov nyhuv kav ntev, pib sai sai ntawm qib biochemical, nrog rau cov nyhuv maj mam thiab nce zuj zus. Ntev- siv sijhawm ntev tuaj yeem ua tiav lub voj voog tsim txiaj ntsig ntawm endocrine axis muaj nuj nqi, uas yog qhov laj thawj tseem ceeb rau nws qhov muaj koob npe hauv kev tawm dag zog thiab tiv thaiv- kev laus.
