HEPIUS Telmisartan 40mg CAS: 144701-48-4

*Telmisartan yog ib yam tshuaj uas feem ntau siv los kho mob ntshav siab thiab qee yam kab mob plawv. Nws belongs rau chav kawm ntawm ** Angiotensin II Receptor Blockers (ARBs). HEPIUS yog lub npe lag luam ntawm Telmisartan muag nyob rau hauv ib hom npe. Hauv qab no yog cov ncauj lus kom ntxaws ntawm Telmisartan:

### ** 1. Tshuaj thiab Khoom Siv Lub Cev **

** Lub npe tshuaj **: 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1}H-benzimidazol]-1'- yl)methyl]-[1,1'-biphenyl] -2-carboxylic acid

- ** Cov mis molecular **: c33h30n4o2

- ** Molecular hnyav **: 514.63 G / Mol

- ** Tshav **: Dawb los yog dawb crystalline hmoov.

- ** Solubility **: me ntsis soluble hauv dej, soluble hauv ethanol, methanol thiab qee cov kuab tshuaj organic.

- ** Melting point **: 261-263 degree

- ** TSIB "**: Telmisartan yog ib qho liipid-soluble compound, yog li nws muaj cov tshuaj nkag siab zoo.

### ** 2. Pharmacological A Siab **

Telmisartan thaiv cov kev khi ntawm angiotensin II rau nws cov receptor (AT1 receptor), inhibits lub vasoconsriction cuam tshuam los ntawm nws, thiab yog li ua si txoj haujlwm hauv qab no:

- Txo cov ntshav siab.

- Txhim kho lub plawv ua haujlwm thiab txo qis myocardial hypertrophy.

- Tiv thaiv lub raum (tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib nephropathy).

- Tej zaum yuav muaj kev txhim kho me ntsis ntawm cov tshuaj insulin.

Piv nrog rau lwm lub arbs, Telmisartan yuav muaj ib qho kev siv agonist **, uas muaj qee yam kev tswj hwm lipid metabolism thiab cov roj av metabolis.

### ** 3. Pharmacokinetics **

- ** Absorption **:

Nws yog nqus tau sai sai tom qab cov kev tswj hwm ntawm qhov ncauj, thiab cov xyoob txheem, thiab cov xyoob sib tw tau txog 40% {1}}%. Cov zaub mov tsis muaj qhov cuam tshuam tseem ceeb rau nws nqus.

- ** XOOM **:

The distribution volume is large (500 L), mainly distributed in tissues such as the liver, kidneys and heart. The plasma protein binding rate is very high (>99.5%).

**Metabolism **:

Nws yog tsuas yog tawm hauv cov kua tsib raws li cov tshuaj qub, nrog rau lub siab me me metabolism thiab tsis muaj kev koom tes ntawm CYP450 enzyme system (tsuas yog CYP2C19).

- ** Kev tso tawm **:

Kev tso tawm hauv cov quav tso nyiaj rau 97%, thiab tsuas yog 1% hauv cov zis.

- ** Ib nrab neej **:

Telmisartan muaj ntshav ntev ib nrab-lub neej ntawm li ** 24 teev **, yog li nws tuaj yeem muab ib zaug ib hnub.

### ** 4. Muab thiab Siv **

- ** Tus Neeg Laus Dosage **:

- Thawj koob tshuaj ib txwm yog **40 mg ib hnub ib zaug**, uas tuaj yeem hloov kho rau **80 mg ib hnub ib zaug** nyob ntawm qhov mob.

- Qhov siab tshaj plaws pom zoo koob tshuaj yog **80 mg / hnub**.

- **Cov neeg laus lossis cov raum tsis zoo**:

Tsis tas yuav hloov koob tshuaj, tab sis cov neeg mob lub raum tsis zoo yuav tsum siv ceev faj.

- **Dosage**:

Nws tuaj yeem noj nrog zaub mov lossis ntawm lub plab khoob.

### 5. Duration ntawm kev siv yeeb tshuaj **

- ** Pib ntawm cov nyhuv **:

Nws pib siv nyob rau hauv 0.5-1 teev tom qab noj cov tshuaj, thiab mus txog qhov siab tshaj plaws antihypertensive nyhuv hauv li 4 teev.

- ** Lub sijhawm ua haujlwm **:

Cov nyhuv antihypertensive ntawm ib koob tshuaj tuaj yeem kav ntev dua 24 teev **, ua rau nws yog ib qho tshuaj zoo rau kev tswj ntshav siab thoob plaws hnub.

### 6. Cov kev tsis zoo tshwm sim**

- **Common **:

- kiv taub hau, qaug zog

- Cov pa taws tsis xis nyob (xws li xeev siab, raws plab)

- hypotaction (tshwj xeeb tshaj yog thaum noj tshuaj rau thawj zaug lossis kho cov tshuaj)

- ** Tsis tshua muaj **:

- Hyperkalemia (tshwj xeeb tshaj yog thaum siv sib xyaw ua ke nrog lwm cov tshuaj uas nce cov ntshav ntau qib)

- Ua kom muaj zog ntawm cov neeg mob raum (ntau dua hauv cov neeg mob raum lossis noj lwm yam tshuaj me me)

- Kev tsis haum tshuaj (pob liab, khaus, thiab lwm yam)

### ** 7. Contraindications thiab ceev faj **

- ** Cov teeb meem ":

- Ua xua rau Telmisartan lossis nws cov kev ua kom zoo.

- Cov poj niam cev xeeb tub (tshwj xeeb tshaj yog nyob rau lub thib ob thiab peb lub hlis twg ntawm cev xeeb tub) thiab cov poj niam pub niam mis.

- Mob siab heev.

- **Cov kev ceev faj**:

- Siv ceev faj rau cov neeg mob hypovolemia (xws li lub cev qhuav dej hnyav).

- Ua tib zoo saib xyuas cov ntshav cov poov tshuaj thaum siv ua ke nrog cov tshuaj diuretics, ACE inhibitors lossis cov tshuaj potassium.

- Saib xyuas muaj nuj nqi ntawm lub raum (tshwj xeeb tshaj yog thaum lub raum muaj txiaj ntsig yog qhov tsis zoo lossis NSAIDs raug coj).

### 8. Nta thiab qhov zoo **

- **Long-acting**: Cov nyhuv ntev, tuaj yeem noj ib hnub ib zaug, yooj yim rau cov neeg mob ua raws.

- ** Kev Tiv Thaiv Kev Tiv Thaiv Kev Tiv Thaiv Kev Tiv Thaiv **: Kev tiv thaiv ntxiv rau cov neeg mob siab (xws li ntshav qab zib nrog kub siab).

- **Metabolism-friendly**: Tej zaum yuav muaj qee yam kev txhim kho ntawm lipid metabolism thiab qab zib metabolism, haum rau cov neeg mob metabolic syndrome.

** HEPMIUS HOM TELMISTAN (Telmisartan (Telmisartan) ** yog ib qho tshuaj antihypertensive uas yog rau lub angiotensin II relgeion thaiv kev thaiv av (arb) chav kawm. Cov hauv qab no yog cov lus qhia ntxaws ntxaws rau nws cov pejxeem siv tau, ua haujlwm ntawm txoj cai, thiab siv thiab muab tshuaj:

### **Cov pejxeem**

1. **Cov neeg mob ntshav siab**

Telmisartan feem ntau yog siv los kho cov ntshav siab tseem ceeb (xws li kub siab yam tsis muaj qhov laj thawj meej) thiab txo qis kev pheej hmoo ntawm cov kab mob plawv los ntawm kev tswj ntshav siab.

2. ** Cov neeg mob uas muaj kev pheej hmoo siab

Telmisartan is suitable for patients who are at risk of cardiovascular disease, such as coronary heart disease, diabetes with hypertension, or patients with a history of stroke or myocardial infarction.

3. ** Cov neeg mob uas muaj kab mob raum **

Hauv qee cov neeg mob uas muaj kab mob raum, telmisartan tuaj yeem pab qeeb qeeb ntawm lub raum muaj nuj nqi, tab sis nws yuav tsum tau raug ntsuas los ntawm tus kws kho mob raws li tus neeg mob qhov xwm txheej tshwj xeeb.

4. **Cov neeg mob uas tsis tuaj yeem zam ACE inhibitors**

Telmisartan yog lwm txoj hauv kev Ace Inhibitors (xws li enalapril) thiab haum rau cov neeg mob uas tsis tuaj yeem tiv thaiv acibitors vim tias hnoos qhuav li hnoos.

### ** Yuav ua li cas nws ua haujlwm **

TelMisartan ua haujlwm los ntawm kev xaiv thaiv angiotensin II (AT1 receptor). Cov ntsiab cai tshwj xeeb yog raws li hauv qab no:

1. ** THIAJCIT VASOConsconstrict **

Angiotensin II yog cov khoom tseem ceeb uas ua rau vasoconstriction. Telmisartan thaiv nws txoj kev khi rau AT1 receptors, ua rau vasodilation, yog li txo cov ntshav siab.

2. ** Txo cov sodium thiab dej khaws cia ua ke **

Telmisartan txo qis kev tso tawm ntawm aldosterone, yog li txo qis sodium thiab dej tuav, txo cov ntshav siab ntxiv thiab txo lub nra ntawm lub plawv.

3. ** Tiv thaiv cov hlab plawv **

Kev siv lub sijhawm ntev ntawm Telmisartan tuaj yeem txo qhov kev pheej hmoo ntawm cov xwm txheej plawv, xws li myocardial infarction thiab mob stroke.

4. ** Kev tiv thaiv lub raum **

Telmisartan txo cov ntshav siab hauv lub glomerulus, ua rau qeeb qhov tshwm sim ntawm cov proteinuria, thiab tiv thaiv lub raum ua haujlwm.

### **Dosage and Administration**

Cov tshuaj thiab kev tswj hwm ntawm Telmisartan yuav tsum tau hloov kho los ntawm tus kws kho mob raws li qhov xwm txheej tshwj xeeb ntawm tus neeg mob. Cov hauv qab no yog cov kev xav tau ntau npaum li cas:

1. **Kev Kho Mob Ntshav Siab**

- ** Thawj koob tshuaj **: Feem ntau 40 mg, ib hnub ib zaug.

- ** TUECTIONS **: tuaj yeem hloov kho rau 20-80 mg, ib zaug ib hnub raws li xav tau.

- ** Qhov koob tshuaj ntau tshaj **: Tsis pub ntau tshaj 80 mg / hnub.

2. **Cov neeg mob uas muaj kev pheej hmoo siab plawv**

- Cov koob tshuaj pom zoo yog 80 mg, ib hnub ib zaug. Thaum pib kho, ntshav siab yuav tsum tau saib xyuas kom tsis txhob muaj qhov tshwm sim ntawm hypotension.

3. **Yuav ua li cas coj**

- Telmisartan tuaj yeem nqa ntawm ib lub plab khoob lossis nrog zaub mov thiab tsis cuam tshuam los ntawm kev noj haus.

- Noj rau ntawm lub sijhawm ruaj txhua hnub pab tswj cov tshuaj ruaj khov.

4. **Kev ceev faj**

- **Cov neeg mob laus**: Feem ntau tsis tas yuav hloov koob tshuaj, tab sis yuav tsum tau soj ntsuam ze.

- ** Cov neeg mob uas muaj cov npe tsis tsim nyog **: Tsis tas yuav muaj kev hloov kho qhov yuav tsum tau, tab sis cov neeg mob uas muaj lub txim tsis txaus yuav tsum tau siv nrog kev ceev faj.

- **Cov neeg mob uas muaj mob hepatic impairment**: Cov neeg mob uas mob me mus rau nruab nrab yuav tsum tsis txhob noj ntau tshaj 40 mg.

### **Nco ntsoov**

1. ** Tej yam me me **

- Cov neeg mob uas tsis haum rau telmisartan lossis nws cov khoom ntxiv.

- Cov poj niam cev xeeb tub (tshwj xeeb tshaj yog nyob rau lub thib ob thiab thib peb trimesters) thiab cov poj niam lactating.

- Cov neeg mob uas muaj mob hepatic tsis zoo los yog biliary cirrhosis.

2. ** Kev phiv zoo **

- Kiv taub hau, hypotension, rov qab mob, raws plab, thiab lwm yam.

- Kev siv mus ntev yuav tsum tau saib xyuas cov ntshav siab, electrolytes thiab lub raum ua haujlwm tsis tu ncua.

3. 4 Cov Tshuaj Tiv Thaiv Yeeb Tshuaj **

- Nws tuaj yeem txhim kho cov nyhuv antihyperthtensive thaum siv sib xyaw ua ke nrog lwm cov tshuaj antihyperensive.

- Siv nrog ceev faj thaum siv nrog poov tshuaj-sparing diuretics lossis poov tshuaj tshuaj rau tiv thaiv hyperkalemia.

### cov ntsiab lus

Hepieve hom Telmisartan yog kev nyab xeeb thiab siv tau tshuaj antihypertensive siv nrog cov teebmeem plawv thiab cov caldal tiv taus cov teebmeem. Cov neeg mob yuav tsum tau coj nws nruj raws li kws kho mob cov lus qhia thiab ua raws li kev ua haujlwm kom ntseeg tau thiab kev nyab xeeb.

Telmisartan yog ib qho kev siv phom angiotensin II REEPT ABRESSISTS (Arb) siv los kho kev kub siab thiab txo txoj kev pheej hmoo ntawm cov kab mob plawv. Telmisartan ntawm hom Hepius tau qhia cov txiaj ntsig zoo hauv kev lag luam thiab thoob ntiaj teb. Cov hauv qab no yuav qhia nws cov ntsiab lus tseem ceeb thiab cov txiaj ntsig hauv kev nthuav dav los ntawm ntau qhov kev xav:

### ** 1. Kev siv yeeb quav tshuaj ntawm kev ua thiab ua tau zoo rau **

- ** Kev xaiv siab ": Telmisartan yog ib tug xaiv siab angiotensin II receptor (AT1 receptor) kev thaiv kev. Los ntawm inhibiting qhov kev ua ntawm AT1 cov khoom siv, nws ua tau zoo txo ​​vasoconstriction, sodium ion reallsorption thiab lwm yam kev ua tiav ntawm cov nyhuv muaj kev ntxhov siab ruaj khov.

- ** Kev tshawb fawb ruaj khov thiab ruaj khov kho mob antihypertensive ntawm telmisartensive ntawm cov neeg mob cov ntshav siab, thiab muaj txiaj ntsig zoo rau cov neeg mob thaum sawv ntxov siab thaum sawv ntxov).

- ** Ntau lub plawv tiv thaiv kab mob **: Ntxiv nrog rau cov nyhuv antihypertensive, Telmisartan kuj txo cov xwm txheej ntawm cov hlab plawv los ntawm kev tiv thaiv kab mob thiab cov tshuaj tiv thaiv antioxidant, tshwj xeeb tshaj yog rau cov neeg mob uas muaj teeb meem ntshav siab, xws li ntshav qab zib, plawv tsis ua hauj lwm thiab metabolic syndrome.

### ** 2. Hepiev hom khoom zoo thiab ua kom zoo dua **

- ** Cov qauv tsim khoom nruj **: HEPIUS hom Telmisartan txais cov txheej txheem tsim khoom thoob ntiaj teb thiab kev tswj xyuas zoo, thiab ua tau raws li cov qauv kev cai nruj nruj ntawm kev lag luam xws li Europe thiab Tebchaws Meskas.

- **High-purity raw khoom**: HEPIUS siv high-purity raw cov ntaub ntawv los xyuas kom meej cov kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj thaum txo qhov tshwm sim tsis zoo tshwm sim.

- **Optimized formulation technology**: Los ntawm kev siv cov micronization siab heev thiab kev tso tawm thev naus laus zis, HEPIUS's Telmisartan formulation muaj bioavailability ntau dua thiab ua raws li tus neeg mob zoo dua.

### ** 3. Clinical daim ntawv thov qhov zoo **

- ** Dav siv tau **: Telmisartan yog dav pom zoo rau kev kho mob monotherapy thiab kev sib xyaw ua ke, tshwj xeeb tshaj yog rau cov neeg mob uas tsis kam noj cov tshuaj diuretics lossis calcium channel blockers.

- **Kev tiv thaiv kab mob plawv**: HEPIUS hom Telmisartan tau pom tias muaj txiaj ntsig zoo hauv kev txo qis kev pheej hmoo ntawm cov kab mob plawv xws li myocardial infarction thiab stroke, thiab tshwj xeeb tshaj yog tsim rau cov neeg mob uas muaj kev pheej hmoo siab.

- ** Txhim kho cov kab mob metabolic **: Telmisartan muaj cov khoom tshwj xeeb ntawm kev txhawb nqa PPAR- receptors, uas ua rau nws muaj txiaj ntsig ntxiv hauv kev txhim kho insulin rhiab heev thiab txo cov ntshav lipid.

### 4. Tus neeg mob ua raws li qhov kom zoo dua **

- ** Yooj yim noj **: HEPIUS hom Telmisartan feem ntau yog muab rau hauv daim ntawv noj ib zaug ib hnub, uas ua rau cov txheej txheem tshuaj yooj yim dua thiab txhim kho kev ua raws li tus neeg mob.

- ** Tsawg qhov tsis zoo tshwm sim **: Piv nrog rau lwm cov tshuaj tiv thaiv ntshav siab, Telmisartan muaj qhov tshwm sim qis dua ntawm cov tshuaj tiv thaiv tsis zoo, tshwj xeeb tshaj yog qhov tshwm sim ntawm hnoos qhuav yog yuav luag tsis pom zoo (tsis zoo li ACE inhibitors).

- ** Haum rau cov neeg mob laus **: hepius luam telmisartan tau ua tiav thiab yog qhov tshwj xeeb siv rau cov neeg mob laus los ntawm cov neeg laus. Nws txoj kev nyab xeeb thiab kev tsim txom tau raug txheeb xyuas hauv ntau qhov chaw kuaj mob.

### ** 5. Kev sib tw ua lag luam "

- ** Tus nqi tsim nyog **: HEPIUS hom Telmisartan muaj qhov tsim nyog tus nqi, muab cov neeg mob nrog kev xaiv tus nqi zoo.

- ** Kev lees paub thoob plaws kev kho mob **: HEPIUS hom Telmisartan tau pom zoo ua thawj kab tshuaj tiv thaiv kab mob siab hauv cov lus qhia ntawm ntau lub tsev kho mob muaj cai hauv tsev thiab txawv teb chaws.

- **Brand lub koob npe nrov lav **: HEPIUS muaj lub koob npe nrov ua lag luam thiab tau txais kev ntseeg siab ntawm cov neeg mob thiab cov kws kho mob nrog cov khoom zoo thiab txhim khu kev qha.

### 6. Kev tshawb fawb tshawb fawb thiab kev txhawb nqa tshiab **

- ** Kev txhawb nqa cov ntaub ntawv kho mob **: HEPIUS hom Telmisartan tau raug pov thawj tias muaj txiaj ntsig zoo thiab muaj kev nyab xeeb hauv cov neeg sib txawv raws li kev sim ntau thoob ntiaj teb thiab hauv tsev.

- ** Kev tshawb fawb thiab kev loj hlob tsis tu ncua**: HEPIUS tseem nqis peev pab rau kev siv tshuaj kho kom zoo thiab txhim kho cov kev qhia tshiab, kom Telmisartan tuaj yeem ua tau raws li kev xav tau ntau yam kev kho mob.

### ** 7. Cov Kev Nyab Xeeb thiab Cov Neeg Zov Me Nyuam **

- **Environmentally friendly production**: HEPIUS them nyiaj rau kev tiv thaiv ib puag ncig thiab txais cov txheej txheem ntsuab hauv kev tsim Telmisartan kom txo tau qhov cuam tshuam rau ib puag ncig.

- **Kev kawm thiab kev txhawb nqa rau tus neeg mob**: HEPIUS muab kev txhawb nqa kev kawm rau cov neeg mob los pab cov neeg mob nkag siab txog qhov tseem ceeb ntawm kev tswj kab mob thiab txhawb kev ua raws li cov tshuaj.

Hauv cov ntsiab lus, HEPIUS hom Telmisartan muaj qhov txiaj ntsig tseem ceeb hauv kev ua lag luam nrog nws cov txiaj ntsig zoo, cov txheej txheem tsim khoom zoo, kev ua raws li tus neeg mob zoo thiab siv dav hauv kev kho mob. Nws tsis tsuas yog ua tau raws li cov kev xav tau ntawm kev kho mob, tab sis kuj muab cov neeg mob nrog txoj kev npaj kho mob zoo dua thiab muaj txiaj ntsig zoo dua, thiab yog qhov kev ntseeg siab ntawm kev tswj hwm tshuaj xaiv tshuaj.

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Cim npe nrov: Hepius telmisartan 40mg CAS: {{144701-48-4} {{{{{{{{{{} Cov neeg tsim khoom, cov chaw tsim khoom, Hoobkas