Khoom Taw Qhia
Lub npe:Flibanserin
Cov txiaj ntsig ntawm cov khoom:Kev cob qhia cov leeg sib sib zog nqus, kev kho lub cev thiab lub cev shaping
CAS:167933-07-5
Peev xwm: 100mg * 30 / lub raj mis
Yam khoom: Cov ntsiav tshuaj
Txee Lub neej: 24 Lub Hlis(Lub hnub ntim khoom yuav tsum yeej)
Flibanserin yog dab tsi
1. Cov ntaub ntawv yooj yim
Lub npe: Flibanserin
Lub npe tshuaj: 2H-Benzimidazol-2-ib, 1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]{ {9}}piperazinyl]ethyl]-
CAS npe: 167933-07-5
Cov mis mos molecular: CHNOPS (cov qauv qauv molecular tshwj xeeb yog qhov nyuaj thiab yuav tsum tau siv rau cov ntaub ntawv tshuaj lom neeg)
2. Pharmacological kev txiav txim
Flibanserin yog ib qho tshuaj nquag ntawm qhov ncauj nrog cov txheej txheem tseem ceeb hauv qab no:
5-HT receptor regulation: Flibanserin yog ib tug 5-HT1A receptor agonist thiab 5-HT2A receptor antagonist ntawm 5-HT. Qhov kev ua ob zaug no tuaj yeem tswj hwm qib ntawm neurotransmitters ntsig txog kev sib deev muaj siab.
Dopamine receptor binding: Flibanserin tuaj yeem khi rau dopamine D4 receptors, ntxiv rau kev cuam tshuam rau cov txheej txheem neurotransmission, uas yuav muaj txiaj ntsig zoo rau kev sib deev muaj siab.
3. Cov lus qhia thiab kev siv
Flibanserin feem ntau yog siv los kho tus mob kis tau, generalized hypoactive kev sib deev muaj siab tsis meej (HSDD) hauv cov poj niam premenopausal. Qhov kev tsis sib haum xeeb no yog tshwm sim los ntawm kev muaj siab sib deev tsawg ua rau muaj kev ntxhov siab loj lossis nyuaj rau kev sib txuas lus ntawm tus kheej, thiab tsis yog tshwm sim los ntawm kev siv tshuaj los yog lwm yam tshuaj.
4. Cov lus qhia tshuaj
Pom zoo koob tshuaj: feem ntau 100 mg ib hnub twg, noj ua ntej yuav mus pw. Qhov no yog vim tias noj nws thaum tsaug zog tuaj yeem ua rau muaj kev pheej hmoo ntawm hypotension, syncope, raug mob raug mob thiab hauv nruab nrab paj hlwb kev nyuaj siab.
Kev Kho Mob: Yog tias tsis muaj kev txhim kho tom qab 8 lub lis piam ntawm kev kho mob, kev kho mob yuav tsum tau txiav txim siab txiav.
Contraindications: suav nrog kev siv ib txhij nrog cawv, kev siv tib lub sijhawm ntawm nruab nrab lossis muaj zog cytochrome P450 3A4 (CYP3A4) inhibitors, thiab cov neeg mob lub siab puas tsuaj.
5. Kev ceev faj thiab kev mob tshwm sim
Cov kev ceev faj:
Cawv yuav tsum raug txwv tsis pub thaum siv Flibanserin, vim tias kev siv ob qho tib si ua rau muaj kev pheej hmoo ntawm hypotension hnyav thiab syncope.
Ua ntej yuav tshuaj, cov kws kho mob yuav tsum ntsuas tus neeg mob qhov muaj peev xwm tso tseg kev haus cawv thiab sib tham txog qhov tseem ceeb ntawm kev tso dej cawv.
Flibanserin tsuas yog muaj los ntawm cov txheej txheem txwv tshwj xeeb kom ntseeg tau tias kev siv nyab xeeb.
Kev mob tshwm sim:
Kev siv Flibanserin ntev yuav ua rau muaj kev phiv xws li xeev siab, tsaug zog, kiv taub hau, hypotension thiab syncope.
Tshwj xeeb tshaj yog thaum siv nrog cawv, nws ua rau muaj kev pheej hmoo ntawm fainting thiab raug mob.
6. Kev ua lag luam xwm txheej
Flibanserin (ua lag luam raws li lub npe lag luam Addyi) tau pom zoo los ntawm US Food and Drug Administration (FDA) hauv xyoo 2015, tau dhau los ua thawj cov tshuaj hauv keeb kwm uas tau siv rau poj niam kev ntshawv siab.
Txawm hais tias kev lag luam xav tau, kev tshaj tawm thiab kev tshaj tawm ntawm Flibanserin tseem ntsib qee qhov teeb meem, suav nrog cov kev mob tshwm sim, kev txwv kev siv, thiab kev paub txog pej xeem thiab kev lees paub ntawm kev sib deev tsis zoo.
Flibanserin ua haujlwm li cas
Flibanserin yog ib qho tshuaj nquag siv hauv qhov ncauj uas ua haujlwm feem ntau los ntawm kev cuam tshuam nrog cov tshuaj neurotransmitter tshwj xeeb.
1. Tshuaj Mechanism
5-HT Receptor Action
Flibanserin yog ib tug 5-HT1A receptor agonist thiab 5-HT2A receptor antagonist rau 5-HT.
Raws li ib tug 5-HT1A receptor agonist, Flibanserin tsub kom cov kev ua ntawm no receptor, uas yog feem ntau txuam nrog antidepressant thiab antianxiety teebmeem.
Raws li ib tug 5-HT2A receptor antagonist, Flibanserin inhibits qhov kev ua ntawm no receptor, uas pab tswj cov neurotransmitter tshuav nyiaj li cas nyob rau hauv lub hlwb.
Dopamine Receptor Action
Flibanserin tseem tuaj yeem khi rau dopamine D4 receptors, uas ntxiv dag zog rau nws lub luag haujlwm hauv kev tswj hwm kev sib npaug neurotransmitter.
2. Daim Ntawv Thov Kev Kho Mob
Kev kho ntawm Hyposexuality
Flibanserin feem ntau yog siv los kho tus mob kis tau, generalized hypoactive kev sib deev muaj siab tsis meej (HSDD) hauv cov poj niam premenopausal.
Los ntawm kev tswj hwm qhov sib npaug ntawm cov tshuaj neurotransmitters hauv lub hlwb, Flibanserin tuaj yeem txhim kho cov tsos mob ntawm kev xav deev tsawg hauv cov poj niam.
Non-hormonal zog
Piv nrog rau kev kho cov tshuaj hormones, Flibanserin, raws li cov tshuaj tsis yog tshuaj hormones, muaj tsawg dua kev phiv thiab kev vam khom tshuaj.
3. Tshuaj metabolism thiab kev nyab xeeb
Txoj kev metabolic
Flibanserin tuaj yeem hloov mus ua ob yam khoom tsis muaj tshuaj lom DP1 thiab DP2 tom qab oxidative degradation hauv lub cev.
Kev nyab xeeb thiab ceev faj
Txawm hais tias Flibanserin muaj qee qhov kev ua tau zoo hauv kev kho mob ntawm HSDD, nws tseem yuav tsum tau ua tib zoo saib xyuas nws cov kev cuam tshuam tsis zoo thiab kev siv tshuaj yeeb thaum siv nws.
Cov neeg mob yuav tsum sab laj nrog kws kho mob ua ntej siv kom nkag siab txog kev siv thiab kev ceev faj ntawm cov tshuaj.
Qhov pom zoo npaum li cas thiab siv Flibanserin?
Flibanserin yog ib yam tshuaj tshiab uas tsis yog tshuaj hormonal uas yog siv los kho cov kev ntshaw deev tsawg (HSDD) hauv cov poj niam. Cov ntaub ntawv tshwj xeeb txog nws cov koob tshuaj pom zoo thiab kev siv yog raws li hauv qab no:
Pom zoo koob tshuaj
Qhov pom zoo koob tshuaj Flibanserin yog 100 milligrams (mg) ib hnub, uas yog, noj 1 100 mg ntsiav tshuaj txhua zaus.
Yuav siv li cas
Flibanserin yuav tsum tau noj thaum sawv ntxov. Qhov no yog vim tias noj nws thaum sawv ntxov tuaj yeem ua rau muaj kev pheej hmoo ntawm hypotension, fainting, raug mob raug mob, thiab hauv nruab nrab paj hlwb (CNS) kev nyuaj siab (xws li pw tsaug zog thiab sedation).
Yog tias qhov koob tshuaj ntawm Flibanserin tsis tuaj yeem ua ntej yuav mus pw, nws yuav tsum tau txuas ntxiv ntawm cov koob tshuaj tsis tu ncua ua ntej yuav mus pw rau hnub tom qab, thiab tsis txhob muab ob npaug rau koob tshuaj kom tsis txhob noj tshuaj.
Nyob rau hauv cov nqe lus ntawm kev kho mob lub voj voog, yog tias tus neeg mob tsis soj ntsuam cov tsos mob ntawm kev txhim kho tom qab 8 lub lis piam ntawm kev kho mob tas li, kev kho mob yuav tsum raug txiav txim siab.
Cov kev ceev faj
Kev siv ib txhij ntawm Flibanserin thiab cawv yuav ua rau muaj kev pheej hmoo ntawm hypotension thiab qaug zog, yog li txwv tsis pub haus cawv thaum siv.
Kev siv flibanserin nrog rau nruab nrab lossis muaj zog cytochrome P450 3A4 (CYP3A4) inhibitors tuaj yeem ua rau cov tshuaj ntau ntxiv, ua rau hypotension thiab syncope, yog li kev siv nrog cov tshuaj no yog contraindicated. Yog tias xav tau cov tshuaj no, lawv yuav tsum pib tsawg kawg 2 hnub tom qab tso tseg flibanserin, lossis flibanserin yuav tsum tau nres tsawg kawg 2 hnub ua ntej pib cov tshuaj no.
Flibanserin tsis haum rau cov poj niam postmenopausal, txiv neej, menyuam yaus, cov neeg mob lub siab ua haujlwm tsis zoo, thiab cov poj niam cev xeeb tub thiab lactating (cov kev sim tsiaj tau pom tias cov khoom no tuaj yeem tso tawm los ntawm cov kua mis, tab sis tseem tsis tau txiav txim siab seb cov khoom no puas tuaj yeem tso tawm. los ntawm tib neeg cov mis nyuj lactating poj niam yuav tsum tsis txhob pub niam mis thaum siv nws).
Thaum siv flibanserin, cov neeg mob yuav tsum zam cov kev ua ub no uas yuav tsum tau muaj siab, xws li kev ua haujlwm ntawm lub tshuab lossis kev tsav tsheb, kom tsis txhob muaj kev phom sij.
Cov txiaj ntsig ntawm Flibanserin hauv Fitness
Cov txiaj ntsig ntawm Flibanserin hauv kev qoj ib ce yog qhov tseem ceeb hauv cov hauv qab no:
1. Kev cob qhia cov leeg sib sib zog nqus
Cov nyhuv zoo: Raws li lub hauv paus ntsiab lus ntawm resonance, Flibanserin tuaj yeem ua tau zoo ntawm cov leeg nqaij hauv lub cev. Cov leeg sib sib zog nqus no feem ntau nyuaj rau kev tawm dag zog tag nrho hauv kev ua kis las.
Kev qoj ib ce: Thaum siv Flibanserin rau kev tawm dag zog, tsis yog tsuas yog cov leeg nqaij sib sib zog nqus ntawm lub plab yuav ntxiv dag zog, tab sis kuj tseem yuav ua kom cov leeg sib sib zog nqus ntawm pob tw, hauv siab thiab caj npab yuav tsum tau ua haujlwm tib lub sijhawm.
2. Kev kho lub cev thiab ua kom zoo
Beautify lub cev: Txoj kev tawm dag zog ntawm Flibanserin tuaj yeem ua kom lub cev zoo nkauj zoo nkauj thiab kho cov cwj pwm phem xws li hunchback.
Shaping kab: Nruam Flibanserin kev cob qhia tuaj yeem tsim lub cev zoo meej kab, ua rau lub cev ntau dua thiab zoo nkauj.
3. Kev kho thiab tiv thaiv kab mob
Txo qhov mob: Flibanserin muaj txiaj ntsig zoo rau kev kho lossis tiv thaiv cov kab mob hauv qab thiab lub xub pwg. Nws tuaj yeem ntxiv dag zog rau cov leeg pob txha pob txha, txhim kho tus txha nraub qaum hauv lub sijhawm luv luv, txhim kho lub cev zoo, thiab tiv thaiv kev mob nraub qaum thiab teeb meem intervertebral disc.
Txhim khu kev ua haujlwm: Rau cov neeg laus, Flyx stick tuaj yeem txhim kho kev sib koom tes, txo qhov mob, thiab tiv thaiv pob txha thiab poob los ntawm kev tawm dag zog cov leeg sib sib zog nqus.
4. Ntau yam ntawm cov neeg siv
Cov kev xav tau sib txawv: Flyx stick yog haum rau cov neeg nyiam kev qoj ib ce ntawm txhua theem, txawm tias cov neeg ncaws pob, cov neeg ua haujlwm hauv chaw ua haujlwm, cov neeg noj qab haus huv, lossis cov neeg laus thiab menyuam yaus, txhua tus tuaj yeem tau txais txiaj ntsig los ntawm nws.
Yooj yim nqa: Flyx stick yog lub teeb yuag thiab nqa tau yooj yim, thiab tuaj yeem siv tau txhua lub sijhawm thiab nyob qhov twg, txawm nyob hauv tsev, hauv chaw ua haujlwm lossis sab nraum zoov, koj tuaj yeem tawm dag zog.
5. Lwm cov txiaj ntsig
Txhim kho qhov concentration: Cov tub ntxhais hluas tuaj yeem txhim kho lawv cov kev xav tau los ntawm kev siv Flyx stick rau kev cob qhia.
Ua kom cov metabolism ntxiv: Kev qoj ib ce nrog Flyx stick tuaj yeem txhawb cov metabolism, uas pab lub cev noj qab haus huv thiab tswj qhov hnyav.
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FAQ
Q: Flibanserin kho HSDD li cas?
A: Flibanserin sib tw nrog 5-hydroxytryptamine (5-HT) los khi rau receptors ntawm postsynaptic membrane, tiv thaiv 5-HT los ntawm exerting nws inhibitory nyhuv rau kev sib deev muaj siab, yog li tsis muaj zog lub hauv paus paj hlwb. inhibitory teb rau kev sib deev muaj siab, nce qib ntawm dopamine uas txhawb kev sib deev muaj siab, thiab nce excitability, yog li ua tiav lub hom phiaj ntawm kho HSDD.
Q: Qhov kev tshawb fawb tseem ceeb ntawm Flibanserin yog dab tsi?
A: Ib txoj kev tshawb nrhiav nyiaj txiag los ntawm German kws tshuaj tuam txhab Boehringer Ingelheim thiab koom tes nrog University of North Carolina, University of Virginia, Lub Tsev Kho Mob Cov Poj Niam ntawm Ottawa Tsev Kho Mob hauv Canada, thiab University of Pavia hauv Ltalis qhia tias Flibanserin tau pom zoo. Kev ua tau zoo thiab kev kam rau siab rau kev sib deev (HSDD) hauv cov poj niam premenopausal.
Q: Nqe Lus Nug 5: Lub ntsiab contraindications thiab kev ceev faj ntawm Flibanserin yog dab tsi?
A: Teb 5: Lub ntsiab contraindications ntawm Flibanserin muaj xws li: cov neeg mob uas muaj mob loj heev daim siab mob, hypotension, thiab keeb kwm ntawm cawv los yog yeeb tshuaj yog txwv tsis pub siv nws; Cov poj niam cev xeeb tub, cov poj niam pub niam mis, thiab menyuam yaus kuj tsis haum rau kev siv. Cov kev ceev faj tseem ceeb suav nrog: tsis txhob haus lossis txwv kev haus cawv thaum siv kom tsis txhob cuam tshuam cov metabolism thiab nqus cov tshuaj; cov neeg mob uas muaj kab mob plawv yuav tsum sab laj nrog kws kho mob ua ntej siv; nws yuav ua rau muaj kev phiv xws li qaug zog lossis tsis muaj kev xav, thiab yuav tsum tsis txhob tsav lub tsheb lossis cov cuab yeej siv tshuab ua haujlwm uas yuav tsum tau muaj siab thaum siv.
Q: Nqe Lus Nug 6: Cov kev phiv tshwm sim ntawm Flibanserin yog dab tsi?
A: Teb 6: Cov kev mob tshwm sim ntawm Flibanserin tuaj yeem suav nrog xeev siab, tsaug zog, kiv taub hau, hypotension, thiab syncope. Tshwj xeeb tshaj yog thaum siv nrog cawv, nws yuav ua rau muaj kev pheej hmoo ntawm syncope thiab raug mob.
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