Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

pill

product-1400-1400

Cov khoom lag luam

### Stada Hom Tshuaj Nolvadex (20Mg) Cov Lus Qhia Kom Tau Cov Lus Qhia

#### 1.} cov tshuaj tiv thaiv

** Cov npe nrov **: Tamoxify Citrate

** NOJ NOJ NOJ NIAM **: NOLLVADEX (tsim los ntawm Stada)

** Qhia tias **:

- Kev kho mob estrogen receptor-zoo (ER +) Cancer mis thiab Metastatic tus mob cancer mis thiab metastatic mis.

- Kev tiv thaiv tus mob cancer mis nyob rau hauv cov poj niam muaj kev pheej hmoo siab (xws li BCA cov noob caj noob gene transations).

- siv rau kev kho mob ntxiv (tswj ovulation) .

** Mechanism ntawm Kev Ua **:

Tamoxifen yog xaiv cov tshuaj estrogen modulator (cov lus) uas txwv tsis pub muaj cov pa hluav taws xob hauv cov pob txha sib tw hauv cov pob txha thiab cov menyuam yaus.

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#### 2. lub cev thiab tshuaj lom neeg

{{0 {}}} **} ** cov qauv tshuaj **:

- molecular cov mis: c₃₂₃₂₃₇₃₇₃₇ (Citrate daim ntawv)

- molecular hnyav: 563.65 g / mol

- Lub Npe Siv Lub Npe: (z) -2- [{}}}}} {4} {} {} {} {}

{{02.}} ** solubility thiab stability **:

- ** Solubility **: Soluble me ntsis hauv dej (txog 0.}}}}}}}}}}, yooj yim solvents hauv cov ethanol thiab chloroform.

- ** STABLY **: Yuav tsum tau muab tso rau ntawm lub teeb, nkag siab txog kev ya raws thiab kub, thiab tuaj yeem ua rau muaj kev kub ntxhov (>)℃.

{{0 {}}} ** Daim Tsim Kev Zam Txim **:

- Cov khoom xyaw tseem ceeb: Tamoxifen citrate (sib npaug rau 20 mg tamoxifen paus) .

- Cov khoom xyaw tsis ua haujlwm: Lactose, microcrystalline cellulose, hypromellose,} {{1 }regration.

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#### 3. ntsiav tshuaj tsos thiab ntim

{{0 {}} ** Cov yam ntxwv lub cev **:

- ** Xim **: 20MG NolvaX tsim los ntawm Stada feem ntau yog dawb rau kev hloov pauv dawb lossis dawb paug {3}

- ** LOGO **: "STAD" lossis "20" tej zaum yuav raug kaw rau saum npoo ntawm cov ntsiav tshuaj rau kev qhia yooj yim.

- ** Qhov loj me ** cov cheeb tsam yog hais txog 6-8 mm, rov qab ua tuab, yooj yim mus rau nqos.

2.} ** ** ** ** ** ** ** **

- Cov khoom ntim uas tsis zoo yog aluminium blacker board, 10 ntsiav tshuaj tauj ib pawg, thiab 3 ntsiav tshuaj (30 ntsiav tshuaj) ib lub thawv.

- Lub thawv ntim khoom yog cim nrog cov naj npawb hauv qab, hnub tas sij hawm thiab cov cim tshuaj tiv thaiv kab mob, uas tau raws EU GMP qauv.

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#### 4. cov ntsiab lus zoo

{{0 {{}}} ece efficiency thiab xaiv tau **:

- Rau cov neeg mob uas muaj mob cancer, 5 xyoos ntawm kev ua kom muaj kev pheej hmoo ntawm 40% (NSABP B} {} .

- Nws muaj cov nyhuv hluav taws xob zoo li kev tiv thaiv ntawm cov pob txha thiab txo qhov kev pheej hmoo ntawm cov osteoporosis.

{{0 {{}} ** Zoo siab rau kev thev taus **:

- piv nrog kev siv tshuaj kho mob, nws muaj cov kev phiv me me thiab tus neeg mob siab ua raws li .

- Siv cov ntaub ntawv ntev ntev (5-10 xyoo) muaj cov ntaub ntawv kev nyab xeeb txaus, tshwj xeeb haum rau cov tub rog hluas.

{{0 {}}}} formation **:

- raws li cov tshuaj tsis muaj patented, tus nqi ntawm cov tshuaj uas tsim los ntawm Stada yog 30% {% qis dua li ntawm cov tshuaj qub {}}

{{0 {{}} ** Multi-secorario Daim Ntawv Thov **:

- Nws muaj ob qhov cuam tshuam txog kev kho mob thiab kev tiv thaiv, txo tus mob cancer mis contralateral mis los ntawm li 50% .

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#### 5. pharmacokinetics

{{0 {{}}} ** nqus thiab faib khoom **:

- ** Qeeb rau npe rau ntawm qhov ncauj ": Txog 30%, noj tsis cuam tshuam rau nqus dej.

- **Peak time (Tmax)**: 4-7 hours, plasma protein binding rate> 98%.

{{02. me ntsis ** me me thiab cov metcretion **:

- ** Hloov pauv mus rau hauv kev ua kom nquag plias ({} hydoxytamoxifen, endoxifen) los ntawm daim siab cyp3A4 / 2C9 enzyme {}}

- ** ib nrab-lub neej **: {5-7}} hnub rau niam txiv yeeb tshuaj, txog 14 hnub rau cov metabolite nquag {}}

- ** excretion **: Feem ntau yog excreted los ntawm feces (65%), ib qho me me los ntawm cov zis (9%) {3} {3}

{{0 {{}} ** Hloov kho rau cov neeg tshwj xeeb **:

- cov neeg mob uas muaj lub siab ua haujlwm lub siab yuav tsum tau txo cov tshuaj, thiab cov uas muaj kev puas tsuaj ntawm lub cev tsis tas yuav kho qhov noj tshuaj .

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#### 6. kev phiv thiab tswj kev pheej hmoo

{{0 {{{}}} ece cov cai uas tsis zoo **:

- Cov Flash Flashes kub (txog 40% ntawm cov neeg mob), kev ua yeeb yaj kiab qhov paum, kev coj khaub ncaws.

- Cov pa taws kev tiv thaiv cov pa roj (xeev siab, cem quav), thiav me me thbomococytopenia .

{{0 {{}} ** Kev pheej hmoo loj **:

- ** Thromboembolism (: Kev pheej hmoo ntawm Voov Venin Dombosis nce {{1} {1} {1} .

- **Endometrial cancer**: Long-term use (>2 xyoos) ua rau muaj kev pheej hmoo los ntawm 2-4 lub sij hawm, thiab kev soj ntsuam gynecological tsis tu ncua.

- ** RETINOPATHY **: Tsis tshua muaj tab sis yuav tsum tau ceeb toom rau kev hloov pauv hauv lub zeem muag .

3.}} ** contraindications **:

- Cev xeeb tub (kev pheej hmoo ntawm teratogenicity), keeb kwm yav dhau los ntawm thrombosis, thiab kev ua xua rau kev ua tsis zoo yog contraindicated .

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#### 7. noj thiab cov thawj coj ua

- ** DAY Tus qauv **: 20 mg / hnub, coj los hais txog ib zaug lossis ob zaug .

- ** Kev kho mob **: Kev kho mob uas yuav raug cog lus feem ntau kav5-10 xyoo (raws li NCCN cov lus qhia) .

- ** XA DAILS **: Cov neeg mob uas muaj menyuam-PGHG B / C Liver ua haujlwm yuav tsum txo cov koob tshuaj los ntawm ib nrab.

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#### 8. cia thiab ruaj khov

- ** Cia cov neeg muaj sijhawm **: Tiv thaiv los ntawm lub teeb, hauv qab 25 degree, txheeb ze cov av noo<60%.

- ** Lub sijhawm sijhawm tas sijhawm **: feem ntau 36 lub hlis nyob rau hauv unpovened xeev, noo-pov thawj tom qab qhib .

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#### 9. part pest: stada

- ** TEEB TUAG **: 1895, Lub taub hau nyob hauv phem homburg, lub teb chaws Yelemees .

- ** Cov xwm txheej thoob ntiaj teb **: Ua cov lag luam cov tshuaj uas muaj peev xwm hauv Tebchaws Europe, nrog kev lag luam npog 120 lub teb chaws.

- ** Tswjhwm Zoo **: Ua raws EU ema cov qauv muaj pov thawj los ntawm FDA thiab MHRA.

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#### 10.} Kev Ua Lag Luam Kev Ua Haujlwm thiab Kev Kawm Rau Cov Neeg Mob

- ** Cov nqi sib tw **: Txog {{{{{{{0.8-1.2 / ntsiav tshuaj (nyob ntawm cov cheeb tsam kev pov hwm hauv cheeb tsam).

- ** TSWV YIM COV TSWV YIM **:

- Noj cov tshuaj ntawm lub sijhawm nyob rau ib hnub, thiab tsim kom tau txais koob tshuaj tsis dhau 12 teev .

- zam kev sib koom ua ke nrog cov nom tswv muaj zog cyp3a4 qhov tseem ceeb (xws li Rifampicin) lossis inhibitors (xws li ketoconazole) {{4}

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#### xaus

Stada's Nolvadex 20MG ntsiav tshuaj tau dhau los ua ib qho ntawm cov kws kho mob thiab kev sib koom tes ua rau cov neeg mob kev nyab xeeb vim nws cov kev coj noj coj ua kom zoo nkauj vim tias muaj kev coj ua kom ua tiav tus mob tsis tu ncua