Lub hauv paus rau phau ntawv
Cov khoom lag luam
### Systemtic Qhia Txog Indada Hom ArimideX (Aastrozole) 1mg ntsiav tshuaj
#### 1.} cov tshuaj tiv thaiv
** ARIMIDEX (AFASTROZOLE) ** Yog cov tshuaj uas tsis yog los ntawm cov tshuaj tiv thaiv kab mob hauv ntiaj teb no los ntawm kev ua tau zoo ntawm cov hluav taws xob estrogen synthesis thiab tseem ceeb txo cov kev loj hlob ntawm cov qog ua haujlwm, nruj kev tswj hwm ntawm cov anequThaum thiab tus nqi zoo {}}
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#### 2. pharorchological cov khoom thiab cov tshuab ntawm kev ua
{{0 {}} ** phiaj **
Anastrozole kev sib tw sib tw ntawm kev sib tw ntawm androstenione ntau tshaj li 96%, Estradeniol (Estronen)
{{0 {}} ** Xaiv tau zoo **
Raws li cov tshuaj tsis yog-steroidalal, Aastrozole tsis cuam tshuam nrog adrenal cortiders synthesces,
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#### 3. lub cev thiab tshuaj lom neeg
{{0 {}}, cov qauv tshuaj **
- ** "}}}}}}}}} {}}} methylpropionitrile)
- ** Molecular cov mis **: C17H19N5
- ** Molecular hnyav **: 293.37 g / mol
- ** tus lej lej **: 120511-73-1
{{0 {{}} ** Siv lub cev thiab tshuaj tsis zoo **
- ** Pom zoo ** ** Dawb rau off-dawb crystalline hmoov, tsw ntxhiab .
- ** Solubility **: soluble me ntsis hauv dej (txog 0.}}}}}}}}}, yooj yim solvents hauv cov tshuaj maj mam ua xws li methanol thiab ethanol.
- ** STABLY **: Nyob ruaj khov nyob rau hauv chav tsev kub, yuav txwv nyob rau hauv lub teeb lossis vaum ib puag ncig thiab yuav tsum tau muab ntim thiab khaws cia kom deb ntawm lub teeb .
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#### 4. noj qab haus thiab cov yam ntxwv uas pom
{{0 {}} ** Ntsiav tshuaj.
- ** SPECIFICATION **: Txhua ntsiav tshuaj muaj 1 mg ntawm Aleaszole, uas yog zaj duab xis-coated ntsiav tshuaj {}}
- ** xim thiab cim cim **: Cov ntsiav tshuaj tsim los ntawm Stada feem ntau ** Cov kab mob daj lossis cov kab sib tsoo lossis sib faib ua ke lossis faib rau lwm sab rau kev faib tshuaj
- ** Muab cov khoom xyaw txheej xws li hydroxypropylulose (HPMC) txhawm rau txhim kho kev ruaj ntseg thiab nqos palatability {}}
{{0 {}}} ** Sau cov lus qhia tshwj xeeb **
Feem ntau siv yog aluminium tshuab hluav taws xob ntim, 14 lossis 28 ntsiav tshuaj ntim ib lub thawv, nrog Desiccant kom ntseeg tau tias noo noo-pov thawj {}
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#### 5. Kev Siv thiab Kho Mob Cov Ntawv Thov
1.} ** Cim lub ntsiab **
- ** Kev kho mob mob rau mis thaum ntxov, siv los tiv thaiv kev rov ua haujlwm thaum phais mob tom qab kev kho mob, cov chav kawm.
- ** Kev kho mob qog nqaij hlav rau kab mob khaub thuas, siv ua tus mob cancer mis) uas yog qhov zoo rau estrogenone receptor (PR +) {4 {4}
- ** HOWSOCHUV NTXIV Kev kho mob **: ua ke nrog cov tshuaj khomob los txo cov qog ntim thiab txhim kho kev phais mob kom ua tiav.
2. ** Rov qab ua tau zoo dua **
- ** Txhim kho cov kev muaj sia nyob zoo **: piv nrog tamoxifen, itastrozole tseem ceeb txo qhov kev pheej hmoo ntawm kev rov qab los ntawm 40%.
- ** Tswj cov pob txha metastasis **: Los ntawm inhibiting tshuaj estrogen, nws txo qhov kev vam meej ntawm cov leeg nqaij anteolytic nyob.
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#### 6. Cov khoom lag luam zoo thiab cov tseem ceeb
{{0 {}}}} Ec efficiency thiab Xaiv tau **
- inhibitory kev ua si tiv thaiv aromatase yog ntau tshaj 100 zaug ntawm cov tshuaj tiv thaiv thaum ntxov, thiab tsis muaj kev pheej hmoo ntawm cov tshuaj steroid {}}
{{0 {}} ** Txaus siab rau **
- Qhov tshwm sim ntawm cov kev mob tshwm sim sib xyaw (xws li cov kub nrawm thiab mob sib koom tes) yog qis dua ntawm cov tshuaj siv tshuaj, thiab tus neeg mob ua kev ua kev ua raws siab yog high.
{{03., qhov ncauj yooj yim **
- ib qho kev xaiv noj 1
{{0 {}}} ececical **
- Raws li hom tshuaj tsis meej, Stada tus nqi yog 30% {% qis dua li cov tshuaj uas muaj nyiaj txiag rau cov neeg mob {}}
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#### 7. Tshuaj Pharmacokinetic Khoom
{{0 {}}}} ** nqus thiab hluav taws xob **
- ** Bioavailability **: Ceev Kev Ua Haujlwm Tom Qab Qhov Ncauj Kev Tswj Xyuas, ncav cuag peak kev tshuaj tiv thaiv (CMAX) hauv li 2 teev tsis muaj kev cuam tshuam kev nqus kom nqus tau.
- ** PREEIN khi tus nqi **: Txog 40%, tsuas yog khi rau albumin.
{{02. me ntsis ** metabolism thiab ua kom zoo nkauj **
- ** Metabolic Pathwocized **: Metabolized los ntawm daim siab cyp3a4 thiab n-dealkylation, tsis muaj cov metabolites, tsis muaj cov metabolites {4 4}
- ** ib nrab-lub neej **: Txog 50 teev, tso cai ib zaug cov thawj coj txhua hnub {}}
- ** excretion **: 85% yog excreted los ntawm cov quav, thiab 10% yog tawm los ntawm zis {}}
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#### 8. kev nyab xeeb thiab phiv
{{01.}} Cov Kev Ruaj Ntseg Zoo **
- ** kub flashes ** (qhov tsis sib haum yog li 30%-40%), ** Kev mob pob txha ** (25%, mob mob taub hau.
- ** Kev siv pob txha **: Siv tau cov pob txha ua kom ntev yuav ua rau muaj kev pheej hmoo ntawm cov kab mob osteoporosis, thiab cov tshuaj vitamins xav tau {}}
{{0 {}} ** mob hnyav tab sis tsis tshua muaj kev pheej hmoo **
- ** Cov xwm txheej plawv **: xws li myocardial ischemia (<1%).
- ** OF cov siab enzymes **: Lub siab ua haujlwm yuav tsum tau saib xyuas tsis tu ncua.
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#### 9. kev sib cuam tshuam yeeb tshuaj
{{0 {{{}} ** Estrogen tshuaj ** (xws li ntawm cov tshuaj tiv thaiv menyuam yaus thiab yuav tsum zam rau kev sib xyaw ua ke.
{{02. ** Cenytoin, Phenytoin) tuaj yeem txo nws cov ntshav siab) tuaj yeem hloov kho .
3.}}}}}} ** Kev siv tam sim no tuaj yeem txwv tsis pub muaj kev txwv tsis pub {{.
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#### 10.} Mob Cov Lus Qhia
{{0 {}} ** Qhov thiab siv thiab siv tau **
- ** Ntses Tshuaj **: 1 ntsiav tshuaj (1 mg) ib hnub, orally ntawm lub sijhawm ruaj khov, tsis hais noj qab haus huv {}}
- ** Missed Dose kev kho **: Yog tias koj tsis nco qab koob tshuaj, tsis txhob muab ob npaug rau hnub tom ntej .
2.}}} istaindications **
- Cov poj niam premenopausal, mob siab tsis txaus (tus menyuam yaus-pugh cengies yog concainde.
{{0 {}} ** Cia li kev cia siab **
- Muab cia rau hauv qhov chaw tsaus hauv qab 30℃thiab khaws cia cov ntim dej noo qub-pov thawj.
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#### 11.} kev ua lag luam thiab cov ntaub ntawv hom
{{0 {}}} ** Stada Cov Tuam Txhab Stada **
Tsim nyob rau hauv 1895, Stada Ag ntawm lub teb chaws Yelemees tsom rau cov tshuaj muaj zog thiab cov khoom lag luam zoo li qub nrog GMP cov qauv thiab tus nqi-ua hauj lwm zoo {}}
{{0 {}} ** Ua pov thawj zoo **
Muaj ntawv pov thawj los ntawm ntau cov koomhaum tswj tshuaj xws li European Union EMA thiab Asmeskas FDA los xyuas kom ntseeg tau cov tshuaj qub uas muaj cov tshuaj qub uas muaj cov tshuaj qub (astrazeneca arimideX}.
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#### 12. Tshawb nrhiav kev kawm thiab yav tom ntej cov lus qhia
{{0 {{}} ** Kev Kho Kom Zoo Rau Kev Kho Vaj Tsev **
- ua ke nrog CDK4 / 6 inibitors (xws li palbociclib) rau ntev ua kom muaj txoj sia nyob ua ntej ntawm cov neeg mob siab tshaj plaws.
{{0 {}} ** Daim Ntawv Tiv Thaiv Tiv Thaiv **
- HOM PHIAJ TXOJ KEV KAWG GROUCE nrog BCA Gene sib hloov, kawm nws lub peev xwm los tiv thaiv mob qog mis.
{{03. ** Kev loj hlob ntawm cov ntaub ntawv tshiab no **
- Transdermal thaj ua rau thaj ua rau thaj chaw lossis ua rau ntev-ua kom txo tau cov zaus ntawm qhov ncauj tswj hwm.
#### xaus
Anastrozole 1mg ntsiav tshuaj tsim los ntawm Stada tau dhau los ua cov tshuaj tua kab mob {} Cov tshuaj tiv thaiv kev ua ke ntawm tus kws kho mob thiab kev lag luam zoo} lipid qib kom ua tiav qhov sib npaug zoo tshaj ntawm kev ua tau zoo thiab kev nyab xeeb .
Txhawb nqa txoj kev them nyiaj thiab tiv tauj peb
Txhawb txoj kev them nyiaj
Peb txhawb ntau txoj kev them nyiaj
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Cim npe nrov: Qhov zoo tshaj plaws ua zoo ArimideX (Aastrozole) 1mg * 50, Tuam Tshoj Stada hwm ua tau zoo ARIMIDEX (AFASTROZOLE) 1MG * 50 tuam ntxhab, Hoobkas
