Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

pill

product-1400-1400

Cov khoom lag luam

### hom hom Litrozole Capsules 2.5MG cov lus qhia ntxaws ntxaws piav qhia

#### 1.. Taw qhia

Letrozole yog qhov ua tau zoo tsis-steroidal aromatase incomplector-}} Ua ib qho kev xaiv mis uas muaj lub ntsej muag zoo tshaj plaws nrog kev xaiv qog mis nrog nws cov tshuaj muaj kev zoo Thiab kho mob efficacy . Cov lus no yuav muaj cov tshuaj lom neeg, cov khoom siv lub cev, cov ntawv thov kev kho mob thiab kev nyab xeeb.

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#### 2. Cov Khoom Siv Tshuaj

** {1. Cov ntaub ntawv tshwj xeeb tshuaj **

- ** Lub npe tshuaj **: 4,4 '- [(1h}, {} {{} {8} {}}}}

- ** Cov mis molecular **: C₁₇h₁₁n₅

- ** Molecular hnyav **: 285.31 g / mol

- ** tus lej lej **: 112809-51-5

** {2. lub cev thiab tshuaj lom neeg **

- ** Pom zoo ** ** Dawb rau off-dawb crystalline hmoov (api) .

- ** Solubility **: soluble me ntsis hauv dej (txog 0.}}}}}}}}}}}

- ** Qhab **: nkag siab txog lub teeb thiab av noo, yuav tsum tau muab ntim thiab khaws cia kom deb ntawm lub teeb; tshuaj lom neeg muaj zog yog ruaj khov nyob rau hauv lub phote ntawm 1-10.

- ** Melting point **: Txog 185-188 degree.

** {3. capsule composition **

- ** Muab cov tshuaj xyaw ua kom nquag plias **: Txhua cov tshuaj ntsiav muaj 2 {. 5mg ntawm letrozole.

- ** Saib kom zoo, cov lactose, microcrystalline, magnesium stearate, thiab lwm yam}}} stabilizers {2} {2}

- ** CYRSULE Plhaub **: Feem ntau gelatin lossis hydroxypropylulose (cov neeg tsis noj tshuaj), tej zaum yuav muaj titanium dioxide li lub hnub ci {}}

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#### 3. Cov Khoom Muag Hluav Taws Xob

** {1.} muaj txiaj ntsig zoo thiab xaiv tau inhibition ntawm aromatase **

- block cov conterersion ntawm Estriacens los ntawm irrogensibly khi rau cytochrome P450, txo cov qog muaj kev loj hlob {}}

- Ib qho kev xaiv siab dua li thawj-tiam neeg inhibitors (xws li aminoglutethimide), tsis muaj cov cuam tshuam tseem ceeb rau adrenal cortical cortical hormones synthesis.

** {2. zoo heev cov me me bioavailability **

- Kev nqus qhov ncauj nrawm ntawm 99%, {}}}}}}}}}}) .

- Ib nrab-lub neej yog kwv yees li 2 hnub, txhawb nqa ib zaug noj thiab txhim kho tus neeg mob ua txhaum {}}

** {3. Kev kuaj mob efficatory advestion **

- ** Kev kho tus uas yuav ua kom muaj kev pheej hmoo ntawm tus mob cancer thaum 30} {%.

- ** Kev kho siab heev **: Lub hom phiaj teb cov nqi (OR) nce mus txog 20% {2}}%, uas yog qhov zoo dua tamoxifen {}}

- ** Ovarian Stantulation **: Siv rau ovulation induction kev kho mob ntawm cov neeg mob polycystic ovary syndrome (pcos) .

** {4. kev tiv thaiv zoo **

- Cov kev mob tshwm sim ntau yam (kub nrawm, mob sib koom tes) feem ntau yog me me rau qhov nruab nrab, thiab cov xwm txheej hepatotoxicity feem ntau yog qhov tsawg .

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#### 4. cov cev lub cev thiab tsos

** {1. capsule tsos **

- ** Xim **: Cov tshuaj ntsiav tshuaj yog feem ntau tsim nyob rau hauv ob xim (xws li lub teeb xiav nyob rau hauv lub siab tshaj plaws), thiab cov xim tshwj xeeb txawv txav ntawm chaw tsim khoom; Kev siv hom hom yuav siv cov xim hom tshwj xeeb (xws li xim liab thiab dawb) .

- ** ** CARD **: Cov tshuaj ntsiav capsule yuav luam tawm nrog "hnyav 2 {. 5" lossis tus lej batch.

- ** QIB **: Feem ntau yog nruab nrab loj (xws li tsis muaj . 4} capsules) .

** {2.} Cov Ntsiab Lus Cim **

- ** Pom zoo ** ** Cov pob zeb dawb lossis tawv dawb lossis hmoov, tsw ntxhiab .

- ** ntim cov lus qhia tshwj xeeb **

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#### 5. Cov qauv kev thov kho mob

** {1. Qhia **

- Kev Kho Mob Tshaj Plaws thiab Tshaj Tawm Ua Ntej-Kab Rau Cov Poj Niam Postmenopausal (Er +) lossis Progesone Receptor (PR +) Txom Nyem Kab Cancer {}}}

- ovulation induction induction induction (tawm-daim ntawv lo) .

** {2. noj thiab kev tswj hwm **

- ** Muab tshuaj txheem ** ** ib hnub, ib zaug ib hnub, 2 .} 2 mg txhua zaus, tuaj yeem coj ua ntej lossis tom qab noj mov.

- ** Chav kho mob **: Kev kho mob yuav raug cog lus tas mus li 5 xyoo, kev kho mob nce qib kom txog thaum tus kab mob zuj zus {2}

** {3.} contraindications **

- cov poj niam premenopausal, mob siab heev tsis txaus, paub tias muaj kev ua txhaum rau letrozole .

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#### 6. pharmacokinetics

- ** Absorition kev nqus lus, tsis muaj qhov cuam tshuam ntawm qhov ncauj, tsis muaj cov khoom noj tseem ceeb ntawm kev nqus.

- ** TSIAJ ** PLASMA cov protein khi tus nqi 60%, faib tawm dav hauv lub cev nqaij daim ntaub {}}

- ** Metabolism **: metabolized rau cov khoom lag luam tsis ua haujlwm los ntawm daim siab cyp3A4 thiab cyp2a {4 {}

- ** EXCRETION **: Feem ntau yog excreted los ntawm ob lub raum (li 90%), tshem tawm ib nrab-lub neej 48 teev.

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#### 7. kev nyab xeeb thiab kev ceev faj

** {1. kev phiv zoo **

- ** ** ONOCORRINE-RELOTE **: Cov Flash Kub (27%), hmo ntuj tawm hws.

- ** POJ NIAM **:%), Osteoporosis (calsteoporosis (calsteoporosis (calcium d ntxiv ntxiv) .

- ** Pob taws plab **: xeev siab (12%), cem illipation.

** {2. kev sib cuam tshuam yeeb tshuaj **

- ** CYP3A4 INDUCERS ** (xws li Rifampicin) tej zaum yuav txo cov ntshav ntawm Letrozole {}}}}

- ** TAMOXIFEN **: Co-Administration yuav tsis muaj zog tshaj qhov ua tau zoo thiab xav tau kev siv ua ntu zus.

** {3. Kev xyuas cov lus pom zoo **

- Cov hauv paus hniav tsis tu ncua thiab cov pob txha tsis tu ncua (DEXA scan) .

- Dose kev hloov kho tau rau cov neeg mob nrog lub siab ua haujlwm tsis muaj nuj nqi .

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#### 8. cia thiab ntim

- ** Cia tej yam kev cia khoom **: Hauv qab 25 degree, ib puag ncig qhuav deb ntawm lub teeb; ntim los tiv thaiv noo noo tom qab qhib .

- ** Hnub tas sij hawm **: Feem ntau {24-36 lub hlis, saib daim ntawv lo ntim khoom kom paub meej .

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#### 9.} Xaus

Fierce Hom Litrozole Capsules 2 {{}}} nws txoj kev npaj ua kom zoo nkauj thiab kev nyab xeeb} Nyob rau yav tom ntej, nrog kev txhim kho ntawm tus kheej Tshuaj, daim ntawv thov muaj peev xwm ntawm Letrozole hauv kev kho kev kho thiab rov ua tub ntxhais yuav raug tso tawm ntxiv.