SR9011 yog REV-ERB / agonist. Hauv qab no yog cov ncauj lus kom ntxaws txog SR9011:
Product Overview
| English npe | TIAB SA 9011 |
| CAS nr | 1379686-29-9 |
| Cov mis mos molecular | C23H31ClN4O3S |
| Molecular hnyav | 479.04 |
| Formula | khoom, xim yog tsaus daj mus rau tsaus xim av heev |
| Cia tej yam kev mob | kaw, qhuav, tsaus, thiab khaws cia rau hauv lub tub yees ntawm -20 degree |
Mechanism ntawm Action
SR9011 ua rau REV-ERB thiab REV-ERB, nrog IC50 qhov tseem ceeb ntawm 790 nM (qee tus hais tias 670 nM) thiab 560 nM (qee tus hais 800 nM), feem. C-terminus ntawm SR9011 tsev neeg ntawm cov proteins tsis muaj lub npe uas tuaj yeem khi rau lub ligand, tab sis tuaj yeem cuam tshuam qhov kev qhia ntawm Rev-erb protein los ntawm kev nrhiav cov tshuaj tua kab mob nuclear thiab histone deacetylase 3, thiab lwm yam.
Kev siv lub cev
Txawm hais tias SR9011 feem ntau yog siv hauv kev tshawb fawb biomedical, tseem muaj cov ntaub ntawv hais tias nws yuav muaj kev cuam tshuam ntawm kev ua kom poob phaus, txhim kho kev ua siab ntev, txo cov roj cholesterol, thiab txo qhov mob, uas tej zaum yuav ntxim nyiam rau bodybuilders.
Kev siv thiab cov txheej txheem
Dissolution thiab Kev Npaj:SR9011 feem ntau yuav tsum tau yaj hauv cov kuab tshuaj tsim nyog ua ntej siv. Cov kuab tshuaj muaj xws li DMSO, PEG300, Tween-80, thiab Saline/PBS. Qhov zoo tshaj plaws concentration thiab hnyav ua ke yuav tsum tau txiav txim raws li qhov kev sim xav tau thaum lub sij hawm npaj.
Kev tswj hwm:Txoj kev tswj hwm ntawm SR9011 yuav txawv nyob ntawm seb lub hom phiaj kev sim thiab tus qauv tsiaj. Cov kev tswj hwm feem ntau suav nrog kev txhaj tshuaj intraperitoneal thiab gavage. Txoj kev tswj xyuas tshwj xeeb yuav tsum raug xaiv raws li kev sim tsim thiab cov yam ntxwv ntawm cov tsiaj.
Dosage thiab voj voog:Qhov ntau npaum li cas thiab lub voj voog ntawm SR9011 yuav tsum tau txiav txim siab raws li cov kev xav tau tshwj xeeb thiab cov qauv tsiaj. Feem ntau hais lus, qhov ntau npaum li cas yuav tsum raug xam raws li qhov hnyav ntawm tus tsiaj thiab txoj hauv kev ntawm kev tswj hwm, thiab kev toxicity thiab kev ua tau zoo ntawm cov tshuaj yuav tsum raug txiav txim siab. Lub voj voog yuav tsum tau teeb tsa raws li kev sim lub hom phiaj thiab cov txiaj ntsig xav tau.
Cov txiaj ntsig
Regulating lub sij hawm lom neeg:SR9011 tuaj yeem txhawb nqa cov synthesis ntawm cov roj ntsha moos protein REV-ERB hauv lub cev, uas muaj feem cuam tshuam rau kev tswj hwm lub moos lom neeg lub cev. Los ntawm kev tswj hwm kev ua kom REV-ERB protein los ntawm REV-ERB / agonist SR9011, ntau cov txheej txheem lom neeg tuaj yeem cuam tshuam.
Regulating metabolism:SR9011 muaj kev ua haujlwm ntawm kev tswj cov metabolism hauv cov ntaub so ntswg, thiab tuaj yeem cuam tshuam cov txheej txheem xws li lub zog metabolism, insulin rhiab heev, glycogen synthesis, fatty acid metabolism, thiab cholesterol synthesis.
Anti-inflammatory nyhuv:Cov kev tshawb fawb tau pom tias SR9011 tuaj yeem cuam tshuam qhov kev qhia ntawm Tr4, yog li tswj cov kab mob inflammatory. Hauv tib neeg macrophages, nce mRNA kev qhia ntawm SR9011 ncaj qha ua rau txo qis hauv mRNA qhia ntawm cov pro-inflammatory yam cuam tshuam interleukin 6.
Cim npe nrov: sr9011 cas 1379686 29 9, Tuam Tshoj sr9011 cas 1379686 29 9 manufacturers, lwm tus neeg, Hoobkas
