Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

raws

product-1400-1400

Cov khoom lag luam

#### ** 1. Cov Lus Qhia Yooj Yim **

** 1.1 lub npe tshuaj thiab qauv **

- ** Muaj lub npe uas yog **: Yohimbine Hydrochloride

- ** Iupac Npe **: methyl 17 - hydroxyyohen -16 - carboxylate hydrochlate

- ** Molecular cov mis **: C21H26NN2O3 HCL

- ** Molecular hnyav **: 390.9 g / mol

- ** tus lej lej **: 65-19-0

** 1.2 Tau cov thiab Keeb Kwm **

Yohimbe Hydrochloride yog cov alkaloid muab rho tawm ntawm cov tawv ntoo ntawm cov neeg African Rubiaceae nroj tshuag, Nyob rau xyoo pua puv 19, cov pab pawg hauv zos tau siv nws hauv cov tshuaj ib txwm muaj, thiab thaum ntxov xyoo pua 20th tau qhia rau sab hnub poob raws li ib tug hlab ntsha txhawb thiab aphrodisiac.

#### ** 2. Tshuaj thiab Khoom Siv Lub Cev **

** 2.1 lub zog lub cev **

- ** Pom zoo ** ** Dawb rau off-dawb crystalline hmoov, tsw ntxhiab.

- ** Solubility **: Yooj yim soluble hauv dej (txog 1: 1), ethanol (1:10), yuav luag Insoluble hauv ether.

- ** Melting point **: Txog 300 degree (decomposition).

- ** STABLY **: Liaj-rhiab, yuav tsum tau muab cia kom deb ntawm lub teeb; Kev Hygroscopicity muaj zog, yuav tsum tau muab ntim thiab noo noo-pov thawj.

** 2.2 Tshuaj Tshuaj **

- ** Acidity **: PH 4.5-6. {{{}} (1% kev daws teeb meem).

- ** QIB OVECTICOTATORATORATORATION, [] Dex=+50 degree rau {{2} aqu degree (aqueous daws).

- ** ** EV Peaks nqus tau kwv yees li ntawm 226 nm thiab 282 nm (hauv ethanol).

#### ** 3. Kev faib tawm thiab cov lus qhia tshwj xeeb **

** 3.1 Kev Sib Tham los ntawm qhov chaw **

1. ** Lub ntuj extract **

- ** Tus txheej txheem **: Ua los ntawm yohimbine xyoob los ntawm ethanol extraction, acid-banfification, thiab crystallization.

- ** Qhov txiaj ntsig **: ntuj tsim nyog rau "cov khoom cog qoob loo" cov khoom xav tau; Tej zaum yuav muaj cov nqi ntawm synergistic alkaloids.

- ** Qhov tsis zoo **: raug nqi siab, kev coj dawb huv yog nyob ntawm cov thev naus laus zis (feem ntau 95-98%).

2. ** Tshuaj Synthesis **

- ** Tus txheej txheem **: Siv cov lus qhia txog kev ua haujlwm ua ntej, los ntawm ntau-kauj ruam organic synthesis (xws li Mannich cov tshuaj tiv thaiv).

- ** "Zoo dua **: Ntau dua kev coj dawb huv (ntau dua lossis sib npaug nrog 99%), muaj zog batch qhov kev siv cov kev siv.

- ** Qhov tsis zoo **: lub siab ib puag ncig, yuav tsum tau cuam tshuam nrog cov khoom siv hluavtaws los ntawm cov khoom lag luam.

** 3.2 Kev faib tawm los ntawm Purity Theem **

1. ** Qib Kawm Ntawv **

- ** Purity **: Ntau dua lossis sib npaug nrog 99.5% (hauv kab nrog USP / ep pap / ep pharapacopoeia cov qauv).

- ** SIV **: Cov ntaub ntawv tshuaj rawv, siv rau kev kho mob.

- ** ME LUAM NTAWV **: HPLC, Cov hlau hnyav (tsawg dua lossis sib npaug rau 10 ppm), seem ntawm methanol<0.1%).

2. ** Qib Tshawb Xyuas **

- ** Purity **: 95-99%, muaj ib qho me me ntawm impurities (xws li lwm yam yohimbine alkaloids).

- ** Siv ": kev tshawb nrhiav, xws li kev tshawb nrhiav ntawm lub tshuab ntawm {1}} adrenergic receptors.

3. ** Qib Qib Kawm **

- ** Purity **: 90-95%, tej zaum yuav muaj cov nroj tsuag cov chaw nyob lossis hluav taws xob nruab nrab.

- ** SIV **: Cov Khoom Siv Kho Mob Raw, Xav Tau Ntxiv Kev Siv Ntxiv.

#### ** 4. Cov ntsiab lus zoo **

** 4.1 Cov Khoom Muag Zoo **

- ** VIM LI CAS {{{{2- syrenaline recenors **: Xaiv txwv tsis pub txwv 2 cov npe, thiab txhawb noromposition (lipolysis).

- ** Qeeb nruab nrab kev txhawb zog zog **: Cov tshuaj tsawg tuaj yeem txhim kho kev ceeb toom, thiab cov koob tshuaj ntau yuav ua rau muaj kev ntxhov siab (roses-dedent).

** 4.2 Daim Ntawv Thov Cov Lus Zoo **

- ** Kev kho mob **: FDA pom zoo rau kev kho mob ntawm kev puas siab ntsws erectile erectile erectile dysfunction (ED), nrog tus nqi zoo ntawm 30-40%.

- ** Kev ua kis las ntxiv **: Raws li "muaj roj ua rau", nws siv cov khoom siv caffeine kom paub txog cov khoom siv ua ntej).

- ** "Kev tshawb fawb tshawb fawb **: Siv los kawm txog kev xav txog kev ua haujlwm thiab ntxhov siab qauv siv.

** 4.3 kev tsim khoom thiab kev lag luam zoo **

- ** Mas Matthes synthesis synthesis **: Cov txiaj ntsig ntawm cov txheej txheem tseem ceeb yog ntau tshaj 70%.

- **Market demand growth**: The global ED drug market has a compound annual growth rate of 5.2% (2023-2030), and the demand for fat-reducing supplements has surged.

#### ** 5. Cov ncauj lus kom ntxaws piav ntawm daim ntawv thov cov xwm txheej **

** 5.1 Kev Kho Mob **

- ** ED Kev Kho **: Qhov ncauj dim 5-10} mg / sij hawm ib hnub, yuav tsum ua rau mob ntshav siab hloov).

- ** Daim Ntawv Thov Tso Cai **: Kev Tshawb Fawb Txog Kev Tiv Thaiv (tswj hwm monoamine neurotransmitters) thiab ntshav qab zib neuropathy (txhim kho microcirculation).

** 5.2 Cov Khoom Noj Rau Kev Noj Qab Haus Huv thiab Khoom Noj Ua Si **

- ** Cov mis nyuj rog-txo cov khoom noj (1: 2 piv), nws txhim kho txoj kev pw hav zoov los ntawm inhibiting phosphodiesterease.

- ** Muab tshuaj ntau dua **: {{2-5 mg / feem, noj tshuaj ntau dua yuav ua rau cov palpitations (CEEB TOOM BALPITY yuav tsum tau).

** 5.3 Kev tshawb fawb kev tshawb fawb **

- ** Qhov kev tshawb fawb tau txais kev ua haujlwm **: Siv rau kev sim ua haujlwm ntawm 2 lub receptor subtypes (xws li 2a, 2b).

- ** Tsiaj txhu tsiaj **: Txhaum kev ntxhov siab-zoo li tus cwj pwm zoo li tus cwj pwm (nas kom ntxiv rau kev kuaj Maze).

#### ** 6. Kev ua lag luam thiab cov cai **

** 6.1 Kev Lag Luam Lag Luam Hauv Ntiaj Teb "

- ** COV LUS TSEEM CEEB **:

- ** Cov Tebchaws Europe thiab Tebchaws Asmeskas **: Sigma-Aldrich (Tshawb Fawb), Cov Tshuaj Ntsuam Xyuas (Tshuaj Ntsuam Xyuas).

- ** Asia **: Tuam Tshoj yirui technology, Is Nrias teb Sun lub cev (cov khoom siv tsawg).

- ** Cov nqi thib **:

- Kev Tshawb Fawb: $ 50-100 / G (HPLC pov thawj).

- Muaj Qib Kawm: $ 10-20 / g (bulk yuav).

** 6.2 Cov Kev Tswj Tshooj Lus **

- ** USA **: Kev cai lij choj raws li kev noj haus ntxiv, tab sis FDA ceeb toom ntawm nws cov peev xwm muaj kev pheej hmoo.

- ** EU **: Qee lub tebchaws (xws li lub teb chaws Yelemees) sau nws raws li cov tshuaj noj thiab tsis txwv kev muag tshuaj.

- ** Suav **: Tsis pom zoo raws li cov tshuaj, thiab cov ntaub ntawv ntshuam thiab export ntawm cov khoom siv raw yuav tsum muaj "daim ntawv tso cai export) thiab daim ntawv tso cai export".

#### ** 7. Kev Nyab Xeeb Thiab Cov Kev Mob tshwm sim **

** 7.1 kev mob phiv **

- ** ** * ME NYIAM, DRYZON, Cov tawv nqaij ntws, Cov ris tsho tsis xis nyob (tshwm sim ntawm li 15%).

- ** PLOJ NYEEM: Hempertive Crisis, Tachycardia (tsis tshua muaj, ntau dua hauv kev siv ntau dua).

** 7.2 Cov Lus Qhia Txog **

- ** Cov kab mob plawv **: Kab mob plawv, mob raum, mob hlwb (xws li ntxhov siab).

- ** Kev txheeb ze cov teeb meem "ua ke nrog SSRI tshuaj tiv thaiv kev ntxhov siab yuav induce serotonin syndrome.

** 7.3 Cov ntaub ntawv Toxicology **

- ** LD50 ** (RATE): Txog 150 Mg / kg.

- ** THAWJ TSHWJ XEEB KEV PAB **: Cov kev sim tsiaj qhia Hepatocyte Cavitation (Dose ntau dua lossis sib npaug rau 20 mg / kg / hnub).

#### ** 8. Kev Tshawb Fawb Kev Kawm thiab Yav Tom Ntej ...

** 8.1 Kev Tshawb Fawb Txog Frontier **

- ** Ua kom tob zuj zus ntawm cov roj txo cov rog?

- ** NANO Tus Me Nyuam Tawm **: Liposome Procapsulation Technology txhim kho qhov ncauj (tam sim no tsuas yog 15-20%).

** 8.2 cov qauv kev lag luam **

- ** ** Kev txhawb nqa cov kev txhawb siab "Cov neeg siv khoom nyiam tsav" huv "cov khoom lag luam tsim nyog yuav tsum tau daws.

- ** Kev npaj txhim kho sib sib zog tshaj plaws **: Ua ke nrog cov koob tshuaj tsawg sildenafil, tshuav nyiaj li kev kho mob ed thiab kev nyab xeeb.

#### ** 9. Ntsiab lus **

Raws li ib qho kev sib txuas ntxiv, yohimbine hydrochloride raw khoom hmoov cov khoom noj qab haus huv thiab kev tshawb fawb. Nws cov tseem ceeb tus nqi nyob hauv nws qhov tshwj xeeb 2 Kev Tawm Tsam Kev agharism, tab sis kev phom sij kev nyab xeeb yuav tsum siv tshuaj tswj nruj. Nyob rau hauv lub neej yav tom ntej, nrog kev sib tawg ntawm precisugh ntawm precisugh software kev xa tshuaj kev siv thev naus laus zis, nws lub peev xwm nyob rau hauv kev kho kab mob ntawm cov metabolic yuav tsum tau tso tawm ntxiv. Cov neeg tsim khoom yuav tsum sib npaug thiab raug nqi kom tau raws li cov kev xav tau ntawm kev lag luam thoob ntiaj teb.