Hauj lwm lawm

Kev tsis

Lub hauv paus rau phau ntawv

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product-1400-1400

Cov khoom lag luam

### Systems Systems-istradiol raw khoom

Raws li cov tshuaj ntsuab tseem ceeb tshaj plaws, Estradiol tau siv dav hauv cov tshuaj, kev tshawb fawb thiab kev lag luam. Cov kab lus no tau txheeb xyuas nws cov tshuaj chemical, kev faib tawm ntawm cov txheej txheem tseem ceeb, muab cov txheej txheem kev lag luam thiab kev ua lag luam tawm ntawm cov kws ua haujlwm muaj feem xyuam.

### ** 1. Cov ntsiab lus yooj yim ntawm estradiol **

#### 1. Tshuaj lom neeg

- **} {1}} esttradiol ({2}} esttradiol)

- ** tus lej lej **: 50-28-2

- ** Molecular cov mis **: C₁₈h₂₄o₂

- ** MOLECATE LUJ **: 272.38 G / Mol

- ** Pom zoo ** ** Dawb rau off-dawb crystalline hmoov

- ** Solubility **: Yooj yim soluble hauv ethanol thiab acetone, me ntsis soluble hauv dej (txog}. 1 mg / ml, 25 degree).

- ** STABLY **: nkag siab txog lub teeb thiab kub, yuav tsum tau muab cia kom deb ntawm lub teeb ({{1} degree).

#### 2. Lub chaw muag tshuaj

- ** Estrogen receptor binding **: Xaiv tau ER thiab ER, tswj hwm cov ntaub ntawv siv keeb.

- ** Cov teebmeem teebmeem ": tswj hwm tus poj niam kev muaj me nyuam, pob txha ceev thiab lipid metabolism sib npaug.

### ** 2. Kev faib tawm ntawm ESTRADIOL Derivatives **

Txhawm rau ua kom zoo cov khoom siv tshuaj papasokineticetries, estradiol feem ntau siv tau. Cov hauv qab no yog cov khoom siv ester loj dua:

#### 1. ** ESTRADIOL VALERATE **

- ** tus lej lej **: 979-32-8

- ** Molecular cov mis **: C₂₃h₃₂o₃

- ** Nta **:

- ** Kev siv sijhawm ntev dua **: Maj mam hydrolyzes tom qab txhaj tshuaj, thiab cov nyhuv kav rau {2}} hnub.

- ** ** QIB QHOV TSEEB *: Hydrolyzed rau Estradiol los ntawm kev mob plab hnyuv mucosal esterase, nrog ib bioavailability {}}%.

- ** DAIM NTAWV THOV **

#### 2. ** ESTRADIOL Benzoate **

- ** tus lej lej **: 50-50-0

- ** Molecular cov mis **: C₂₅h₂₈o₃

- ** Nta **:

- ** OFFSET Sai Sai **: Peak Ntshav Tshuaj Txhuam {}}} hnub tom qab txhaj tshuaj intr intrus.

- ** Kev npaj ua luv luv ": siv rau kev kho mob cyclic (xws li dysfunctional uterine los ntshav).

- ** Qhov tsis zoo **: ib nrab-lub neej (3-5} hnub), nquag tswj hwm yuav tsum tau ua.

#### 3. ** Estradiol Cypive **

- ** CAS TSIS MUAJ. ** {313-06-4

- ** Molecular cov mis **: C₂₆h₃₆o₃

- ** Nta **:

- ** ALTA-ntev-ua yeeb yam **: Cov nyhuv ntev rau 3-4 lub lis piam tom qab txhaj tshuaj intramuscular.

- ** ** Zoo liipid-soluble **: Haum rau oily txhaj, ncua kev tso tawm.

- ** DAIM NTAWV THOV **: Cov tshuaj hormone hloov kev kho mob (HRT), kev kho mob ntawm prostate.

#### 4. ** Estradiol Enanthath **

- ** CAS TSIS MUAJ. ** {4956-37-0

- ** Molecular cov mis **: C₂₅h₃₆o₃

- ** Nta **:

- ** Seem plig **: Nruab nrab ntawm valerate thiab cypionate, cov nyhuv kav rau {1}} lub lis piam.

- ** Kev siv thoob plaws **: feem ntau siv nyob rau hauv cov tsiaj tshuaj (xws li synchronous Estrus hauv cov tsiaj poj niam).

### ** 3. Cov Txheej Txheem Ntau Lawm thiab Tswjhwm Zoo **

### 1. Synthesis txoj kev

- ** Pib cov khoom siv **: phytososterols (xws li stigmasterols (xws li kev sib tw los ntawm cov kab mob me (xws li Cyanobacteria) los tsim ESRONE.

- ** Kauj ruam tseem ceeb **:

1. ** Cov tshuaj tiv thaiv tawm ntawm **: estrone yog hydrogenated nyob rau hauv ib tug catalyst (xws li pd / bisoing) kom tau txais estradiol.

2. ** Kev hloov kho Esterification hloov kho **: Cov tshuaj tiv thaiv nrog kev sib raug mob anhydrides (xws li gereric anhydride) los ua cov khoom siv ester derivatives.

### 2. Tswjhwm Zoo

- ** Tus Qauv Tshuaj Pharmeia **: Ua tau raws USP / EP / CHP cov kev xav tau, cov khoom ntsuam xyuas suav nrog:

- ** Purity **: HPLC txiav txim siab ntau dua lossis sib npaug rau 99%.

- ** OC LWM YAM PHEM **: Ib leeg impurity tsawg dua los yog sib npaug ntawm 0. 5%, tag nrho cov kab mob tsawg dua los yog sib npaug rau 1. {%.

- ** Muab cov kuab tshuaj uas muaj me nyuam yaus **: methanol thiab acetone ntsib iich q3c txwv.

- ** O ** microbial txwv **: Tag nrho aerobic bacteria tsawg dua los yog sib npaug rau 1000 cfu / g.

### ** 4. Ua daim ntawv thov **

#### 1. Kev Ua Haujlwm Kho Mob

- ** HRT (Cov tshuaj hormone hloov kev kho mob) **: Txo menopaal kub flashes thiab epteoporosis.

- ** Cov kab mob ntawm gynecological **: Kho Amenorrhea thiab kev tuag.

- ** Kev kho mob hlwb **: Kev kho kev kho inhibits qhov kev tsim txom ntawm prostate cancer.

#### 2. Kev Tshawb Fawb Kev Tshawb Fawb

- ** Kev tshawb fawb tau txais kev tshawb fawb **: Siv rau kev txhim kho ntawm ER / ER xaiv ligands.

- ** Tshuaj ntsuam xyuas tshuaj **: Tsim tus qauv vitro ntawm cov tshuaj estrogen.

#### 3. Industrial teb

- ** Cov tshuaj pleev kom zoo nkauj **: Siv hauv cov kev txiav txim siab qis rau kev tiv thaiv tawv nqaij (txwv hauv qee lub tebchaws).

### ** 5. Kev Lag Luam Kev Lag Luam thiab Cov Cai Tswj **

#### 1. Cov tuam ntxhab loj

- ** Suav teb **: Zhejiang Xianju tshuaj, Hubei Yuanda Kev Tshawb Fawb Kev Tshawb Fawb thiab thev naus laus zis.

- ** Tebchaws Europe **: Bayer, Novartis.

### 2. Kev xav tau lag luam

- ** Tsav tsheb rau qhov kev xav tau **: Kev siv thoob ntiaj teb tau nce ntxiv rau HRT, thiab kev lag luam loj yuav tsum tau tshaj li US $ 5 nphom hauv 2025.

- ** QUB RAUG sib txawv ntawm cov neeg hauv cheeb tsam sab nrauv thiab cov lag luam hauv nroog rau 60% ntawm kev lag luam sib koom, thiab Asia-Pacific cheeb tsam muaj kev loj hlob sai tshaj plaws (8% txhua xyoo kev loj hlob).

#### 3. Cov kev cai tswj hwm

- ** Daim Ntawv Tso Cai Ntshuam **: Cov teb chaws feem ntau yuav tsum muaj daim ntawv tso cai tsim yeeb tshuaj "thiab GMP daim ntawv pov thawj.

- ** SULE KEV THAUJ MUS LOS ** ({{{{1} degree Txias saw tsheb thauj mus los, lub teeb pov thawj pom kev thiab dej noo.

### ** 6. Kev nyab xeeb thiab kev cia **

- ** Kev muaj kev phiv **: Siv tau ntev ntev yuav ua rau kev pheej hmoo ntawm kev pheej hmoo ntawm kev pheej hmoo ntawm kev pheej hmoo ntawm cov kev pheej hmoo ntawm kev pheej hmoo thiab mob cancer mis (ntau npaum li cas yuav tsum ua nruj ua ntej).

- ** Cov teeb meem me me **: Cov neeg mob uas muaj mob cancer mis thiab tsis sib haum xeeb loj los ntshav.

- ** Cia tej yam khoom tiv thaiv **: Muab cia rau hauv qhov chaw kaw, txias thiab qhuav, nrog lub neej txee ntawm feem ntau 24 lub hlis.

### ** 7. Yav Tom Ntej Prospections **

- ** Cov ntaub ntawv DOSAGE TSHIAB **: Nanocrystal Tshuab txhim kho qhov ncauj Bioavailability.

- ** MENYUAM LUB CAIJ **: Tsim cov allonists eronists kom txo cov kev mob tshwm sim.

- ** Synthesterized ntsuab **: enzyme catalysis txheej txheem txo cov pa phem ib puag ncig.

### ** Xaus **

Raws li cov tswv yim hluav taws xob ester, estradiol thiab nws cov derivatives yuav ua tau kev kho mob ntau dua los ntawm kev kho mob ntawm kev kho mob thiab cov txheej txheem ntau lawm. Kev tswj hwm nruj thiab tswj kev ua tiav yog qhov tseem ceeb lees paub rau lawv daim ntawv thov kev nyab xeeb.