Lub hauv paus rau phau ntawv

CJC1295 with DAC2

musclepic 2

Cov khoom lag luam

Tshooj 1: Kev faib tawm thiab cov pawg loj

Raws li lawv npaj siv thiab cov qauv qauv zoo, CJC-1295-DAC cov ntaub ntawv lossis cov khoom lag luam tuaj yeem faib ua peb pawg:

Kws tshawb fawb tshuaj -} Cov ntaub ntawv tshawb fawb qib peptides uas tau ua tiav cov khoom siv hluav taws xob, xav tau kev ua kom muaj zog, thiab siv cov ntaub ntawv ntau lawm.

Kev Tshawb Nrhiav {- Cov kev tshawb fawb txog kev tshawb fawb thiab kev coj ua vitro / tsiaj txhu ib txwm muaj, feem ntau pom hauv chaw soj ntsuam thiab kev tshawb fawb kawm.

Cov ntaub ntawv raw thiab cov qauv tsim qauv: muaj nyob rau hauv F hmoov Tsab Ntawv Kev Loj Hlob lossis txheej txheem ua kom zoo dua, nrog cov kev ua kom zoo dua qub, nrog kev ua kom zoo dua qub thiab cov cim ua ntej siv hauv tib neeg kev tshawb fawb.

Cov ntaub ntawv me me tuaj yeem ua raws li cov tshuaj noj thiab cov qauv, suav nrog cov khoom nyoos, solub so formulations, thiab cov peptide peptide.

Ntu 2: Cov qauv tshuaj thiab cov khoom siv dag zog

Cov tub ntxhais ntawm CJC-1295-DAC yog cov saw hlau polypetride nrog cov kev ua haujlwm zais cia zoo sib xws rau ib txwm ua. Cov amino acid leaduab tau tsim tsa kom txhim kho kev txhim kho ib qho affinity thiab kev ruaj khov. Dac cov khoom lag luam muaj cov txheej txheem hluav taws xob muaj peev xwm ntawm cov tshuaj txhuam hniav (xws li albumin

Nyob rau hauv cov nqe lus ntawm physicochemical cov khoom, cjc - 12} - dac- cov hmoov dawb lossis xoob. Nws cov molecular qhov hnyav yog qhov ntau dua li ntawm ib qho luv peptide, nyob ntawm seb cov kev sib txuas lus thiab DAC kev sib txuas. Lub Peptide cov solubility hauv dej nyob ntawm nws cov amino acid composition thiab muaj cov ntsev hydrocoric acid lossis acetate ntsev lossis acetate ntsev. Nws yog feem ntau soluble hauv dej deionized, buffers, lossis tsawg-feem pua organic cov kuab tshuaj, tab sis tsis zoo solve hauv chav tsev kub. Peptide daim ntawv cog lus ua rau nws nkag siab cov kua qaub thiab cov hauv paus, muaj peev xwm ua rau hydrolysis ntawm cov qib qib heev. Nws yog feem ntau pom zoo kom tsis txhob muaj lub teeb muaj zog, kub, lossis muaj cov kua qaub muaj zog los tiv thaiv kev ua kom tsis txhob muaj kev cuam tshuam thiab kev tsis pom zoo.

NTU 3: Nraus thiab Xim

Siab - purity cjc {}} 12}-dac hmoov los yog cov hmoov dawb, hnav khaub ncaws zoo thiab tsis muaj qhov tsis txaus ntseeg. Nrog kev txo qis kev coj dawb huv lossis cov hmoov tsis zoo, cov hmoov yuav tshwm sim daj lossis grey, uas yuav qhia tau tias muaj cov khoom lag luam oxidation, lossis hluavtaws ntawm hluavtaws. Tom qab kev sib tov, kev daws yuav tsum meej, tsis muaj xim, lossis me ntsis pob tshab, milky dawb. Kev nruj me me, cov nplais, lossis dej nag lossis daus qhia txog cov kev cai tsis raug cai lossis kev cia siab thiab yuav tsum tau nthuav dav ntxiv.

Tshooj 4: Qhov Zoo thiab Muaj Peev Xwm

Thawj qhov txiaj ntsig ntawm CJC - 12}- dac yog nws ncua ntev ntawm kev txiav txim. Piv rau luv luv-ua yeeb yam ghrh analogs, DAC kev hloov kho tau ntev ntev ntev ntev thiab tswj cov nyhoo tsawg dua gh-stimulating effection. Cov txiaj ntsig zoo muaj xws li:

Kev siv hluav taws xob ntev ntawm cov qog pituitary tso cov tshuaj loj hlob, nce ntxiv kev txhim kho protein, cov nqaij mosaly.

Txuas ntxiv ib nrab - lub neej pab txhawb kev txhaj tshuaj thiab txo cov zaus ntawm kev tshawb fawb, yooj yim} kev kho cov ntawv thov.

Ntau ruaj khov Gatsidulation theoretically tso cai rau tus qauv zoo nkauj

Vim yog qhov muaj peev xwm thiab cov hom phiaj ntawm peptides, lawv yuav ua rau pom cov tshuaj hormones yav dhau los hauv qee qhov ntsuas hauv lub sijhawm luv luv.

Nws yuav tsum raug sau tseg tias ntau ntawm cov kev zoo tam sim no raws kev tshawb fawb thaum ntxov lossis kev txiav txim siab tsis txaus, thiab cov lus teb sib txawv.

Ntu 5: Txheej txheem cej luam ntawm kev ua tshuab ntawm kev ua (tsis -} ua haujlwm piav qhia)

CJC -} 12} {4 4}}} Dac Indirection In Programmes ntawm Ghrh ntawm Hypothalamic-Pituitary Axis. Cov lus qhia ntawm DAC tsis hloov nws cov lus qhia yooj yim ntawm lub pob ua haujlwm ntawm GHRH receptor. Txawm li cas los xij, los ntawm kev rov kho cov protein lossis ncua kev tshem tawm lub zog ntev, nws tau ua kom muaj kev txhawb nqa ntev dua thiab muaj kev txhawb nqa. Qhov txheej txheem sib txawv no los ntawm kev txhaj tshuaj ncaj qha ntawm kev txhaj tshuaj loj (exogenous gh), uas yog li ntawd tau muaj kev ua tau zoo rau cov neeg mob uas muaj kev ua kom zoo nkauj.

Ntu 6: Pharmacokinetics Thiab Ruaj Ntseg

Cov yam ntxwv ntawm cov chaw muag tshuaj tau cuam tshuam los ntawm tib neeg hloov pauv, peptide sequamility, Dac hom, thiab kev tswj hwm. Cov txheej txheem tag nrho yog qhov tseem ceeb tshaj plasma ib nrab ib nrab - lub neej, nrog cov ncov tom qab thiab ntev dua. Cov metabolism hauv Vivo yog feem ntau ua ke ntawm peptidase hydrolysis, kev ua kom zoo, thiab renal clearance. Hais txog kev ruaj khov, lub peptide yog feem ntau ruaj khov thaum khov lossis tub yees ntawm qis kub; Nkoog -}}}}}}}}}}}}} Kev ua haujlwm nyob rau chav tsev kub, lossis lub teeb muaj zog nrawm nrawm. Cov tshuab tiv thaiv, cov tshuaj tiv thaiv cov tshuaj tiv thaiv, lossis cov antioxidants feem ntau ntxiv rau cov qauv ua kom tau ntev}}} lub sij hawm ruaj khov.

Section 7: Preparation and Formulation Considerations (High-Level Description, Non-Experimental Procedures)

Cov kev txiav txim siab tseem ceeb rau kev npaj ntawm CJC {{1} {{{{4 4} {- kub ua, thiab saib xyuas rau cov kuab tshuaj me me thiab cov lus qhia txog cov kuab tshuaj thiab itotoxins. Tsim qauv yuav tsum txiav txim siab solubility, qhov kev cuam tshuam ntawm pH ntawm kev ruaj khov, thiab qhov xav tau ntawm kev hloov khaub ncaws txias thiab lyophilization kom ntev dua txee lub neej. Txhua qhov kev kuaj mob-qib lossis cov khoom sim-cov khoom lag luam yuav tsum tau tswj hwm thiab tswj kev cai tswjfwm ua ntej nkag mus rau tib neeg kev tshawb fawb.

NTU 8: Kev Tswj Xyuas Zoo Thiab Kev Ntsuas Tus Kheej

Cov hau kev rau kev soj ntsuam qhov zoo ntawm CJC {}}}}}}}}}}}}}}}}}} Cov qauv kev pom zoo, cov qauv kev coj ua, capillary electrophoresis, thiab xaiv tau rau kev ntsuas kev ua haujlwm muaj kev soj ntsuam. Kev ua kom menyuam kawm, endotoxins, rov qab cov organic cov kuab tshuaj, thiab cov hlau hnyav kuj tseem ceeb xeem cov txheej txheem rau kev tso tawm zoo. Batch {- to-batch tsis xwm yeem thiab kev ntsuas kev nyuaj rau kev sib tw ntev.

Tshooj 9: Daim Ntawv Thov Kev Qhia thiab Tshawb Fawb

Thawj cov ntawv thov ntawm CJC - 12}}} dac hauv cov kab mob kev tshawb fawb, thiab kev sib piv ntawm cov tswv yim loj hlob tshiab-txhawb nqa cov tswv yim. Qee qhov kev tshawb fawb thaum ntxov lossis me me tau tshawb nrhiav nws cov peev xwm ntawm kev txhim kho lub cev, txhim kho lub cev kev kho, tab sis ua rau cov kev tsis sib haum xeeb, tab sis cov lus xaus tsis sib haum xeeb. Loj dua, Randomized, tswj cov kev sim kuaj mob yog xav tau los txheeb xyuas nws txoj kev nyab xeeb thiab kev ua tau zoo.

Tshooj 10: Kev Nyab Xeeb thiab Cov Kev Mob tshwm sim - Ceeb Toom Txog Kev Ceev Toom)

Kev siv ntawm lub gh - kev txhawb nqa cov tshuaj muaj peev xwm muaj kev phom sij, thiab cic {} {} dac yog tsis muaj kev zam. Tshaj tawm lossis theoretical kev nyab xeeb txhawj xeeb suav nrog sodium thiab dej los yog mob ntshav qab zib, thiab cov kev tswj hwm hauv ib cheeb tsam, thiab cov lus tsis txaus ntseeg. Vim tias CJC - 1295-DAC qhov kev txiav txim siab nyob rau ntawm endogenary stimary muaj zog tej zaum peb hloov cov tshuaj hormone endogenous hormone kev tawm tswv yim endogenous formacks. Tsis tas li ntawd, txhua tus tswj hwm tus kheej lossis nquag tswjfwm kev cai nqa tau kev pheej hmoo ntawm kev pheej hmoo ntawm kev pheej hmoo ntawm kev pheej hmoo ntawm kev pheej hmoo ntawm kev pheej hmoo loj, yog li kev tshawb fawb thiab siv tau raws li kev cai lij choj thiab kev coj ua zoo. Kev muab lossis txhawb cov kev tshuaj tiv thaiv cov dosing, cov tshuaj Dosagens, lossis kev sim tus kheej yuav tsum zam.

NTU 11: Kev tswj hwm thiab kev txiav txim siab zoo

Hauv ntau lub tebchaws thiab cheeb tsam, kev tsim khoom, faib khoom, thiab tib neeg siv cov tshuaj hluavtaws peptide peptide siv tau nruj me ntsis. Kev siv CJC - 12} {4 4}} dac hauv kev tshawb nrhiav kev kho mob lossis kev cai tswj hwm kev cai. Tshaj {{5 5}} captleet faib lossis siv tsis yog hauv kev sib tw kis las tseem nce kev cai lij choj thiab kev tawm tsam kev tawm tsam doping. Cov kws tshawb nrhiav thiab cov kws kho mob yuav tsum ua raws li cov cai hauv zos, cov cai, kev tshawb fawb kev coj ua zoo thaum tuav cov tshuaj no.

NTU 12: Cia thiab Tsheb Thauj Mus Los

Txhawm rau kom muaj kev ua si thiab kev nyab xeeb, cjc - 1295-dac yuav tsum muab cia rau hauv cov saw txias lossis qis kub. Qhov ntsuas kub zoo tshaj plaws yog teev rau ntawm cov ntawv lo cim, feem ntau ntawm 2 thiab 8℃lossis khov. Tsis txhob rov ua kom khov-lub voj voog khov-lub voj voog, cov kev tuav dag zog, thiab ntev ntev kom muaj lub teeb kub lossis lub teeb. Thaum lub sijhawm thauj mus los, cov khoom yuav tsum tau ntim rau hauv cov thawv ntim lossis khov ua kom haum cov cai thiab yauv ua kom muaj kev soj ntsuam kev ncaj ncees thaum xa khoom.

NTU 13: Kev Pom Zoo Siv thiab Tswj Xyuas (tsis yog koob qhia)

Nyob rau hauv cov ntsiab lus ntawm kev tshawb nrhiav raug cai lossis kev soj ntsuam, suav nrog kev kuaj ntshav, thiab cov tsiaj ntawv lipper, Cov kev tshawb pom tsis meej tias yuav tsum tau tshuaj xyuas sai thiab tsim nyog kev pab kho mob kom tsim nyog. Kev sim ib tus neeg tsis muaj kev pheej hmoo txaus ntshai thiab yuav tsum poob siab, nrog kev taw qhia kev pab tswv yim.

NTU 14: Xaus

CJC {- 12}- dac, tau nyiam cov kev sim siab rau kev nqis tes ua, tau ua rau lub sijhawm tshawb fawb txog kev tshawb nrhiav thiab lub sijhawm ntev hauv Vivo kis tau thiab muaj peev xwm nkag tau. Txawm li cas los xij, pov thawj hais txog nws txoj kev nyab xeeb kom ntev, kev ua siab tshaj plaws siv cov xwm txheej zoo nkauj, thiab cov kev soj ntsuam cov nyiaj pab cuam tseem muaj txwv. Kev tshawb fawb ntawm hom Peptide no yuav tsum yog ua raws cov qauv kev kawm nyuaj thiab kev tswj hwm kom tsis txhob muaj tib neeg siv tsis tau thiab tswj tau zoo. Rau cov kws tshawb nrhiav thiab cov kws xyaum cov neeg txhawj txog daim teb no, them nyiaj rau kev tswj hwm zoo, kev coj ua thiab kev coj ua yog tsis muaj nqis los ua haujlwm ntxiv.